Issues
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Cover image
Cover Image
Cover: COS-7 cells expressing activator of G-protein signaling 3 (AGS3, green) and disheveled-2 (DVL2; red) with DAPI DNA stain (blue). α2-adrenergic receptor activation leads to redistribution of AGS3 from the cell cortex to DVL2 punctate structures in the cytosol and to the Golgi, and this translocation is reversed by receptor antagonist and by uncoupling of receptor and G protein through cell treatment with pertussis toxin. See article by A. Vural and S. M. Lanier (jcs247908).
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RESEARCH HIGHLIGHTS
STICKY WICKETS
FIRST PERSON
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
p63-related signaling at a glance
Summary: A review of the signaling cascades regulating and regulated by the different isoforms of the p53-related transcription factor p63, as well the role of p63 in disease.
REVIEWS
Microautophagy – distinct molecular mechanisms handle cargoes of many sizes
Summary: Microautophagy is a versatile and conserved type of autophagy. Here, recent progress is reviewed that allows fission-type and fusion-type microautophagy to be distinguished, thus providing a new conceptual framework.
Bring it back, bring it back, don't take it away from me – the sorting receptor RER1
Summary: In this Review we provide an overview of the early secretory pathway protein RER1, which cycles between cis-Golgi and ER, returning ER-resident proteins and unassembled subunits of multimeric complexes back to the ER.
RESEARCH ARTICLES
Diffusion rather than intraflagellar transport likely provides most of the tubulin required for axonemal assembly in Chlamydomonas
Highlighted Article: Using GFP-tagged β-tubulin, we show that most of the tubulin required for axonemal assembly enters Chlamydomonas cilia by diffusion rather than by intraflagellar transport.
Amino acid homeostatic control by TORC1 in Saccharomyces cerevisiae under high hydrostatic pressure
Highlighted Article: A regulatory circuit maintaining intracellular amino acid homeostasis is revealed by studies of yeast growing under high hydrostatic pressure, with a critical role identified for the EGOC–Pib2–TORC1 complex.
The S. pombe CDK5 ortholog Pef1 regulates sexual differentiation through control of the TORC1 pathway and autophagy
Summary: In fission yeast, sexual differentiation is important for survival in environmental changes. We found that Pef1 regulates initiation of sexual differentiation through control of the TORC1 pathway and autophagy.
LFA-1 signals to promote actin polymerization and upstream migration in T cells
Summary: Inflammatory responses require leukocyte migration along the vascular wall. We show that signaling from β2, but not β1, integrins induces cytoskeletal changes needed for upstream migration under shear flow.
Fe65 is the sole member of its family that mediates transcription regulated by the amyloid precursor protein
Highlighted Article: Fe65 is a major intracellular APP-binding protein. We show that Fe65 is a transcription factor, whose nuclear translocation and thus transcriptional capacity is regulated by APP cleavage.
Mitofusin 2 regulates neutrophil adhesive migration and the actin cytoskeleton
Summary: The ER–mitochondria tether maintained by MFN2 fine-tunes Rac activation to regulate neutrophil adhesive migration and adhesion to endothelial cells under shear stress.
Intersection of two key signal integrators in the cell: activator of G-protein signaling 3 and dishevelled-2
Summary: The interaction of the signal integrators AGS3 and DVL2 is regulated by protein phosphorylation, subcellular distribution, and a cell-surface G-protein-coupled receptor.
The role of the α-tubulin acetyltransferase αTAT1 in the DNA damage response
Summary: The α-tubulin acetyltransferase αTAT1 is involved in DNA damage checkpoints and DNA repair through its acetyltransferase activity.
Frustration of endocytosis potentiates compression-induced receptor signaling
Summary: Cancer cells subjected to compressive stress experience frustration of clathrin-mediated endocytosis which, in turn, leads to enhanced receptor signaling.
RACK1 regulates centriole duplication through promoting the activation of polo-like kinase 1 by Aurora A
Summary: The BRCA1-interacting protein RACK1 regulates centriole duplication by acting as a scaffold protein for the phosphorylation of polo-like kinase 1 by Aurora A.
PUBLISHER'S NOTE
Call for papers - Cilia and Flagella: from Basic Biology to Disease

We are welcoming submissions for our upcoming special issue: Cilia and Flagella: from Basic Biology to Disease. This issue will be coordinated by two Guest Editors: Pleasantine Mill (University of Edinburgh) and Lotte Pedersen (University of Copenhagen). Submission deadline: 1 March 2025.
About us

Our publisher, The Company of Biologists, turns 100 this year. Read about the history of the Company and find out what Sarah Bray, our Chair of the Board of Directors, has to say.
Biologists @ 100 - join us in Liverpool in March 2025

We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate the Spring Meetings of the BSCB and the BSDB, the JEB Symposium Sensory Perception in a Changing World and a DMM programme on antimicrobial resistance. Find out more and register your interest to join us in March 2025 in Liverpool, UK. The final deadline for registration is 28 February 2025.
Introducing our new Associate Editors

In this Editorial, JCS Editor-in-Chief Michael Way welcomes five new Associate Editors to the JCS team. These Associate Editors will expand our support for the wider cell biology community and handle articles in immune cell biology, proteostasis, imaging and image analysis, plant cell biology, and stem cell biology and modelling.
How to investigate GPCR signalling in cells

Abigail Pearce and colleagues provide a critical overview of new, state-of-the-art approaches used to quantitatively study G protein-coupled receptor signalling in cells.
JCS-FocalPlane Training Grants

Early-career researchers - working in an area covered by JCS - who would like to attend a microscopy training course, please apply. Deadline dates for 2025 applications: 7 March 2025 (decision by week commencing 21 April 2025) and 6 June 2025 (decision by week commencing 28 July 2025).