Issues

Summary: Myofibroblasts repair injured tissues by producing and contracting collagen scars but they also promote fibrosis. Here, we describe how to facilitate the design of informed anti-fibrotic therapies.

Summary: In order to execute a specific function, cells often acquire a particular shape. Here, we explore the mechanisms driving these morphological changes.

Summary: Osteoclasts are an amazing model to study interactions between cytoskeleton components; their role in osteoclast bone resorption activity can also open opportunities for the treatments against osteoporosis, as reviewed here.

Highlighted Article: PI3Kγ regulates VSMC proliferation independently of its kinase activity by controlling cAMP levels through PDE4D.

Summary: Cep57 and its paralog Cep57l1 redundantly act as a molecular scaffold to recruit the Cep63–Cep152 complex to the proximal end of centrioles for centriole duplication.

Summary: Characterization of two-pore channel type 2 (TPC2)-mediated Ca²⁺ release and ADP-ribosyl cyclase 1-like (ARC1-like) activity during axon extension of caudal primary motor neurons (CaPs) in zebrafish embryos.

Summary: EGFR regulates integrin tension and focal adhesion spatial organization and tunes the mechanical threshold for cell spreading and adhesion.

Summary: Bulli forms a trimeric complex with Mon1–Ccz1 and is crucial for endosomal maturation in nephrocytes.

Highlighted Article: Mitochondrial positioning, ROS levels and the hypoxia response pathway are involved in the activation of the HSF1-mediated heat shock response pathway in mammals.

Summary: Kinesin-2 proteins in Trypanosoma brucei perform a conserved role in flagellum biosynthesis and also have a specialized localization, emphasizing the evolutionary flexibility of kinesin function in trypanosomes.

Summary: Mass spectrometry analysis reveals a large cohort of novel yeast stress granule proteins with intrinsic disordered regions that are sufficient for recruitment to the membraneless stress granule compartment.

Highlighted Article: The exocytic function of clathrin controls the abundance of the Wnt signaling component β-catenin through LRP5/6 and cadherin molecules.

Summary: Ciliary proteins, acting independently of the ciliary axoneme, regulate the dynamics of cytosolic NFκB, but not other signalling pathways, defining an important subset of the inflammatory response.

Highlighted Article: We demonstrate that intercellular transfer of Engrailed homeoprotein involves direct translocation events across the plasma membrane and identify pivotal roles of PIP2 and cholesterol in these processes.

Summary: Mechanical polarization is established in stress fiber networks during migration through cofilin disassembling actin to facilitate the formation of highly prestressed stress fibers needed to break tensional symmetry.

Highlighted Article: Wash, the Wash regulatory complex, capping protein and Arp2/3 are identified as new components of nuclear envelope buds used for nuclear pore complex-independent export of large macromolecule complexes from the nucleus.

Summary: The molecular chaperone Hsp90 is involved in heterochromatic gene silencing and heterochromatin formation by facilitating stability and integrity of RNAi-dependent and -independent effectors in S. pombe.

Summary: Dictyostelium discoideum vacuolins are the functional homologs of flotillins and function in phagocytic uptake and membrane recycling together with myosin VII and talin A, as well as in phagolysosome biogenesis.

Summary: Snail expression induces epithelial cell extrusion through transcriptional control of RhoA contractile signalling and cell–matrix adhesion that may act as a prelude to a metastatic event.

Summary: DISC1, which is important for neuronal synapse formation, and Girdin, which is involved in cytoskeletal reorganization, play essential roles in actin accumulation and cytoskeletal reorganization at the T cell immunological synapse.

Summary: A cellular assay to evaluate albumin endocytosis reveals a novel link between a nuclear protein and a membrane receptor complex.

Summary: The kinetics of the DNA damage sensor Mre11 and the mitotic proteins Polo, BubR1, Bub3 at DNA lesions during mitosis are measured in Drosophila, revealing their order of recruitment.