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RESEARCH HIGHLIGHTS

STICKY WICKETS

FIRST PERSON

CELL SCIENTISTS TO WATCH

CELL SCIENCE AT A GLANCE

Summary: Overview of the selective autophagy of both pathogens and immunoregulators, highlighting a few examples that illustrate molecular strategies developed by pathogens to manipulate selective autophagy for their own benefit.

REVIEWS

Summary: In this Review, we discuss how autophagy impacts on endocytosis, how endocytosis regulates autophagy in mammalian cells and how both pathways impact on quality control of the lysosome.

Summary: A review of recent work on archaea of the genus Sulfolobus that has revealed intriguing parallels between genome organization in these prokaryotes and in metazoan organisms.

SHORT REPORT

Summary: Syndapin, an F-BAR domain protein, regulates the transition from Arp2/3-dependent protrusion remodeling and cap expansion to actomyosin-dependent cap buckling in the Drosophila blastoderm embryo.

RESEARCH ARTICLES

Summary: The identification of redundant pathways that tightly control cellular ATP and adenosine levels provides novel insights into the purinergic mechanisms governing cancer cell metabolism and signaling.

Highlighted Article: The ubiquitin-conjugating enzyme Ubc13–Mms2 contributes to membrane protein sorting in the multivesicular body pathway, thus constituting an additional source of K63-polyubiquitylation beyond Rsp5/NEDD4 in the endocytic compartment.

Summary: We show for the first time that a modified version of Apaf-1 forms an apoptosome-like structure that triggers cell death by using a mechanism that is identical to that used by native Apaf-1

Summary: We have identified an evolutionarily conserved nuclear lamina binding domain in the PRR14 nuclear lamina–heterochromatin tethering protein.

Summary: CSAG1, a novel regulator of mitosis that constrains the pericentriolar material to prevent spindle pole fragmentation, particularly, in cells that lack p53 function.

Summary: Sirtuins regulate organismal growth in planarians by altering animal behavior and disrupting the differentiation of cellular progenitors.

Summary: Analysis of proteomic and transcriptomic data of primary myeloid cells reveals that the β-tubulin isotype Tubb6 participates in osteoclast podosome patterning, sealing zone structure and resorption activity.

Summary: Live microscopy of Aspergillus Golgi cisternae refutes the possibility that maturation of TRAPPI/TRAPPIII into TRAPPII mediates the transition between RAB1 and RAB11 that takes place across the Golgi.

Summary: Pathophysiological excitability was revealed for human cells in dementia. This provides a major advance in understanding of tau-induced brain neuropathology and sheds new light on human models of dementia.

Summary: Two cytoplasmic proteins are shown to be required for paraflagellar rod formation, which are extra-axonemal structures found in the flagella of trypanosomes.

Summary: A newly identified sodium-sensitive potassium channel in brain mitochondria might be involved in regulation of the respiratory chain.

Summary: Uptake of low-density lipoprotein (LDL) through the LDL receptor is required for translocation of phosphatidylethanolamine to the cell surface via ATP binding cassette G1 transporter and the cell–cell fusion of osteoclast-like cells.

Summary: STRIPAK–PP2A promotes peripodial cell fate in the developing Drosophila eye epithelium by antagonizing the Hippo signaling axis, thereby promoting Yorkie activity and suppressing retinal cell fate.

Highlighted Article: The characterization of auxiliary factors in sister chromatid cohesion as identified by genetic interaction mapping in yeast, reveals novel roles for the prefoldin complex and the microtubule-associated protein Irc15.

Highlighted Article: Translesion synthesis polymerases are required for meiotic survival in fission yeast, and their loss disrupts meiotic chromosome segregation and Rec8 dynamics. Replication and DSB repair are unaffected.

Summary: DE-cadherin and Myosin II balance regulates an optimal lateral furrow length for transition of a circular to a polygonal plasma membrane organization in cortical syncytial division cycles in Drosophila embryogenesis.

Highlighted Article: A live-cell assay to monitor heme distribution kinetics identifies GTPases in control of mitochondrial–ER contact sites and dynamics as being critical modulators of heme trafficking.

Highlighted Article: Previously defined canonical stress granule factors are not required for SG assembly in adult Drosophila progenitor cells, suggesting that other cell populations employ a similar noncanonical assembly mechanism in vivo.

TOOLS AND RESOURCES

Summary: We present an upgrade to spinning disk confocal microscopes that dramatically improves photon balance and imaging speed for various imaging applications in projections, while simultaneously preserving super-resolution features.

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