Issues

Summary: Protein synthesis is not always perfect, thus, mechanisms to remove aberrant translational complexes are needed. Mechanisms differ between biological systems and here we compare those of bacteria and mammalian mitochondria.

Summary: A review of centriolar satellite biogenesis and function discussing satellite composition and regulation, along with their involvement in cilium assembly and function, proteostasis and other cellular processes.

Highlighted Article: Proteolytic processing of the nuclear GCN5 histone acetyltransferase by a cysteine protease-like enzyme in the vicinity of the food vacuole is important for its function in Plasmodium falciparum.

Summary: The inactivation domain of STIM1 (IDstim) helps STIM1 prevent spontaneous SOCE via binding to the coiled-coil domain retaining hydrophobic interaction between CCα1 and CC3.

Summary: Development of a ribozyme-destabilized nanoluciferase reporter to monitor changes in gene expression brought about by rhinovirus proteases 2A and 3C.

Summary: Liquid-phase scanning transmission electron microscopy (STEM) was utilized to study whether or not ORAI1 proteins at rest assemble in a dimeric configuration in the plasma membrane of intact HEK cells.

Highlighted Article: Intracellular transglutaminase 2 influences cellular mechanical state, focal adhesion dynamic and FAK activation in response to substrate stiffness, in part by controlling cell contractility through a mechanism involving EGFR.

Highlighted Article: Presentation of integrin-selective, peptidomimetic ligands on nano-patterned substrates reveals the role of α_vβ₃ integrin recruitment to α₅β₁-induced clusters for focal adhesion maturation and endothelial cell spreading.

Summary: We establish a new vector series to efficiently and stably introduce DNA sequences into the fission yeast genome, and use it to generate a set of fluorescent cell biology probes.

Summary: Here, we report a simple LEGO^® bricks-based cell-stretching system that can generate uniaxial cyclic mechanical stretch on cells in tissue culture, demonstrating its use in various applications.