Issues

Summary: This Cell Science at a Glance article describes stomatal development, focusing on the role of transcriptional regulators, cell–cell signaling and polarity proteins.

Summary: We review consequences of mitochondrion-derived stress that modulate cytosolic translation and describe emerging concepts on how homeostasis can be restored upon translation attenuation.

Summary: We review the concepts and evidence for supracellular migration: that is, migration of a cell collective that operates at a level higher than that of the individual constituent cells.

Summary: The exchange factor FARP2 is identified as a polarity-determining protein that is a partner and substrate of aPKCι. Phosphorylation by aPKCι is shown to control the localised action of FARP2 on Cdc42.

Summary: Over 200 alternative splicing events implicated in protein transport at all stages of the secretory pathway are identified, globally establishing alternative splicing as a regulatory layer of membrane trafficking.

Highlighted Article: We describe a comparative analysis of the functions of myosin motors at the Golgi complex in cells normalized by micropatterns and identify MYO1C as a novel player at the Golgi.

Highlighted Article: β1 integrin cytoplasmic splicing allows muscle cells to switch from a signaling to an anchoring and signaling-deficient phenotype through interaction with intracellular isoforms of adapter protein talin.

Summary: A distinctive morphological process of cell alignment in the Drosophila embryonic epithelium reveals that multiple feedback mechanisms in the Rho pathway can fine-tune tissue morphology during development.

Summary: Nuclear speckle fusions occur within chromatin-depleted channels enriched with speckle granules via repeated directional movements of nuclear speckles over several micrometers after transcriptional inhibition, other stresses and during G2.

Highlighted Article: Nuclear actin interactome analysis reveals novel binding partners and functions for actin in the nucleus, with direct binding and regulation of the KAT14 HAT and functional link to pre-mRNA processing.

Summary: Cellular juvenescence is maintained by Gm14230 juvenility-associated lncRNA (JAlnc).

Summary: Troponin I, formerly thought to be a muscle-specific protein, contributes to apico-basal polarity in epithelial and neuroblast cells. Its depletion leads to apoptosis and DNA damage through separate mechanisms.

Summary: Overexpression of Nr5a1 in XX fetal transgenic mouse gonads suppressed Notch signaling and compromised ovarian development, resulting in late-onset infertility.

Highlighted Article: Budding and fission yeast strains stably expressing the ATP biosensor QUEEN, allow reliable observation of ATP dynamics with high spatiotemporal resolution in living eukaryotic cells.