CELL SCIENCE AT A GLANCE
Summary: We review consequences of mitochondrion-derived stress that modulate cytosolic translation and describe emerging concepts on how homeostasis can be restored upon translation attenuation.
Summary: We review the concepts and evidence for supracellular migration: that is, migration of a cell collective that operates at a level higher than that of the individual constituent cells.
Summary: The exchange factor FARP2 is identified as a polarity-determining protein that is a partner and substrate of aPKCι. Phosphorylation by aPKCι is shown to control the localised action of FARP2 on Cdc42.
Genome-wide identification of alternative splicing events that regulate protein transport across the secretory pathway
Summary: Over 200 alternative splicing events implicated in protein transport at all stages of the secretory pathway are identified, globally establishing alternative splicing as a regulatory layer of membrane trafficking.
Highlighted Article: We describe a comparative analysis of the functions of myosin motors at the Golgi complex in cells normalized by micropatterns and identify MYO1C as a novel player at the Golgi.
β1D integrin splice variant stabilizes integrin dynamics and reduces integrin signaling by limiting paxillin recruitment
Highlighted Article: β1 integrin cytoplasmic splicing allows muscle cells to switch from a signaling to an anchoring and signaling-deficient phenotype through interaction with intracellular isoforms of adapter protein talin.
Summary: A distinctive morphological process of cell alignment in the Drosophila embryonic epithelium reveals that multiple feedback mechanisms in the Rho pathway can fine-tune tissue morphology during development.
Nuclear speckle fusion via long-range directional motion regulates speckle morphology after transcriptional inhibition
Summary: Nuclear speckle fusions occur within chromatin-depleted channels enriched with speckle granules via repeated directional movements of nuclear speckles over several micrometers after transcriptional inhibition, other stresses and during G2.
Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing
Highlighted Article: Nuclear actin interactome analysis reveals novel binding partners and functions for actin in the nucleus, with direct binding and regulation of the KAT14 HAT and functional link to pre-mRNA processing.
Summary: Cellular juvenescence is maintained by Gm14230 juvenility-associated lncRNA (JAlnc).
Summary: Troponin I, formerly thought to be a muscle-specific protein, contributes to apico-basal polarity in epithelial and neuroblast cells. Its depletion leads to apoptosis and DNA damage through separate mechanisms.
Nr5a1 suppression during the murine fetal period optimizes ovarian development by fine-tuning Notch signaling
Summary: Overexpression of Nr5a1 in XX fetal transgenic mouse gonads suppressed Notch signaling and compromised ovarian development, resulting in late-onset infertility.
TOOLS AND RESOURCES
Highlighted Article: Budding and fission yeast strains stably expressing the ATP biosensor QUEEN, allow reliable observation of ATP dynamics with high spatiotemporal resolution in living eukaryotic cells.