Issues
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Cover image
Cover Image
Cover: Membrane localisation of an EGFP fusion protein (green) carrying a novel palmitoylation sequence derived from the adaptor protein Gab1 in transfected mouse embryonic stem cells. Nuclei are stained with DAPI (blue). See article by L. Sutherland et al. (jcs.222257).
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RESEARCH HIGHLIGHTS
FIRST PERSON
OBITUARY
REVIEWS
Condensins and cohesins – one of these things is not like the other!
Summary: Condensins and cohesins generate intramolecular DNA loops. Condensin rods extrude DNA to compact chromatin during mitosis, whereas structurally adaptive cohesin rings organize the genome during interphase to regulate gene transcription.
Influence of the extracellular matrix on cell-intrinsic circadian clocks
Summary: Cells in metazoans live within, and interact with, their local extracellular microenvironment. This Review summarises how the extracellular matrix affects the circadian timekeeping mechanism within different cells.
RESEARCH ARTICLES
Constitutive IP3R1-mediated Ca2+ release reduces Ca2+ store content and stimulates mitochondrial metabolism in mouse GV oocytes
Summary: Mouse GV oocytes display spontaneous Ca2+ oscillations that reduce intracellular Ca2+ stores and stimulate mitochondrial metabolic output, maintaining cellular homeostasis during prolonged meiotic arrest.
A global analysis of IFT-A function reveals specialization for transport of membrane-associated proteins into cilia
Summary: Intraflagellar transport complex A is required for the efficient movement of groups of membrane and signal transduction proteins into flagella.
Exocyst subunit Sec6 is positioned by microtubule overlaps in the moss phragmoplast prior to cell plate membrane arrival
Summary: A time-resolved localization screen of multiple subunits of the exocyst complex throughout moss cytokinesis shows that each subunit has a unique spatiotemporal recruitment pattern.
Tunneling nanotubes, a novel mode of tumor cell–macrophage communication in tumor cell invasion
Summary: A novel mechanism of intercellular communication through tunneling nanotubes (TNTs) on macrophage-mediated tumor cell invasion reveals TNTs as a potential therapeutic target.
Identification and characterization of genes encoding the nuclear envelope LINC complex in the monocot species Zea mays
Summary: Genes encoding maize candidates for the core LINC and associated complex proteins have been comprehensively identified with functional validation by one or more assays for several of the KASH genes.
Tau regulates the microtubule-dependent migration of glioblastoma cells via the Rho-ROCK signaling pathway
Summary: Tau governs remodeling of microtubule and actin networks during the tail retraction phase in migrating U87 cells. It also controls the Rho-ROCK signaling via relocation of p190-RhoGAP and FAK proteins.
Comparison of three heterochromatin protein 1 homologs in Drosophila
Summary: A comparative analysis of the three Drosophila HP1 homologs shows that they localize differently, and that HP1a and HP1b repress transcription, whereas HP1c activates transcription.
Loss of the deglutamylase CCP5 perturbs multiple steps of spermatogenesis and leads to male infertility
Summary: Perturbation of post-translational polyglutamylation affects early stages of spermatogenesis in mice: loss of the deglutamylase CCP5 completely prevents the formation of functional spermatocytes.
The integral function of the endocytic recycling compartment is regulated by RFFL-mediated ubiquitylation of Rab11 effectors
Summary: The ubiquitin ligase RFFL regulates ubiquitylation of Rab11 effectors and the integral function of endocytic recycling compartments.
TIMP-1 promotes hypermigration of Toxoplasma-infected primary dendritic cells via CD63–ITGB1–FAK signaling
Highlighted Article: A TIMP-1–CD63–ITGB1–FAK signaling axis in primary dendritic cells drives high-speed amoeboid migration of vehicle cells that facilitate the systemic dissemination of Toxoplasma gondii.
A SEPT1-based scaffold is required for Golgi integrity and function
Highlighted Article: SEPT1 associates with the Golgi complex through GM130, and is required for maintaining Golgi architecture and function by connecting cis-Golgi membranes to the microtubule-nucleating machinery.
GPN does not release lysosomal Ca2+ but evokes Ca2+ release from the ER by increasing the cytosolic pH independently of cathepsin C
Highlighted Article: GPN causes an increase in the cytosolic pH, evoking Ca2+ release from the ER that is independent of cathepsin C.
TOOLS AND RESOURCES
The N-cadherin interactome in primary cardiomyocytes as defined using quantitative proximity proteomics
Highlighted Article: Proximity proteomics reveals a specific and specialized N-cadherin (CDH2) interactome along the cell–cell contacts of primary cardiomyocytes.
PREPRINT HIGHLIGHTS
JCS fast-track option
Have a paper that has been reviewed elsewhere? JCS is pleased to consider such manuscripts for fast-tracked decision making. Send us your manuscript together with the full set of reviews and decision letters, and we will make an initial decision within one week.
Special Issue – Cell Biology of Mitochondria
Our special issue on ‘Cell Biology of Mitochondria’ is now complete. Explore this issue and read the Editorial from our Guest Editors Ana J. García-Sáez and Heidi McBride.
Save the date – Imaging Cell Dynamics
We are delighted to announce that we will be hosting a 2026 Imaging Cell Dynamics meeting. This meeting will provide a unique opportunity to bring together experts working at the interface between cell biology and imaging. Save the date for 11-14 May 2026 and register for more information.
Origin and evolution of mitochondrial inner membrane composition
In this Review, Kailash Venkatraman and colleagues provide an examination of the morphological similarities between prokaryotic intracytoplasmic membranes and mitochondrial inner membranes, and whether cristae evolution has driven specialisation of the mitochondrial lipidome.
Resolution in super-resolution microscopy
Super-resolution microscopy (SRM) has emerged as a powerful tool for biological discovery. In this Perspective, Kirti Prakash and colleagues compile expert opinions on crucial, yet often overlooked, aspects of SRM that are essential for maximising its benefits and advancing the field.
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