Issues

Summary: A Review of recent findings on the intricacies of podosome architecture that enable these structures to act as autonomous force generators.

Summary: We highlight how intracellular organelles and their associated trafficking routes provide diverse feedback for dynamic cell polarity maintenance, and argue that the asymmetric organelle compass is an indispensable element of the polarity network.

Summary: The adaptor proteins HAP1a and GRIP1 form a protein complex in the brain, and co-operate to activate the kinesin-1 subunit KIF5C in vitro.

Summary: RAB11FIP2 associates with AMPA receptors on immobile endosomal compartments, separate from Rab11. After LTP induction, FIP2 disengages from the receptor, allowing synaptic delivery and potentiation.

Highlighted Article: Organoid assays and mathematical modeling suggest that Mark1-mediated fibroblast activation induces type I pneumocyte flattening, resulting in the regulation of distal lung sacculation.

Highlighted Article: Microtubule formation depends on microtubule-organizing centers. We describe three different types of γ-tubulin ring complexes in nuclear and non-nuclear MTOCs in the filamentous fungus Aspergillus nidulans.

Summary: NRAS.Q61K and BRAF.V600E mutations disrupt the responses of melanocytes to keratinocyes and result in distinct morphological changes and movement patterns.

Highlighted Article: Phosphorylation of cortactin by PKD2 at S298 controls the N-WASP-mediated synergistic actin polymerization required for constitutive secretion from the TGN by modulating WIP-dependent sequestration of N-WASP.

Summary: In tetraploid cells, a key regulator, Eg5, and its related kinesins determine spindle polarity, chromosome segregation and, consequently, aneuploidy and chromosomal heterogeneity.

Highlighted Article: A method for rapid, high purity, isolation of lysosomes, mitochondria and peroxisomes from cell lysate was developed based on twin strep tag binding to Strep-Tactin XT magnetic beads.