Cover: Retinal pigment epithelial (RPE-1) cell on a crossbow-shaped micropattern. It was fixed with paraformaldehyde and immunostained with primary antibodies against α-actinin (green) and fluorescently labelled phalloidin (magenta) to reveal actin filaments. See article by F. Senger et al. (jcs236604).
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CELL SCIENCE AT A GLANCE
The liquid nucleome – phase transitions in the nucleus at a glance
Summary: This Cell Science at a Glance article discusses how membrane-less compartments in the nucleus are formed by phase separation and help to organize and regulate nuclear functions.
Multiscale dynamics of tight junction remodeling
Summary: This Review discusses how tight junction remodeling at multiple scales contributes to sustained epithelial barrier function in the face of cell and tissue dynamics.
A homeostatic mechanism rapidly corrects aberrant nucleocytoplasmic ratios maintaining nuclear size in fission yeast
Summary: Nuclear size homeostasis is achieved by a rapid correction mechanism modulating nuclear growth rate in growing fission yeast cells.
Yap induces osteoblast differentiation by modulating Bmp signalling during zebrafish caudal fin regeneration
Summary: Yap regulates, in a non-cell-autonomous manner, Bmp signalling activation in osteoprogenitors, thereby promoting osteoblast differentiation and proper bone formation during zebrafish caudal fin regeneration.
MICAL-L1 coordinates ciliogenesis by recruiting EHD1 to the primary cilium
Highlighted Article: A pool of centriolar γ-tubulin and/or α/β-tubulins anchor MICAL-L1 to the centriole, where it might recruit EHD1 to promote ciliogenesis.
Condensin II protein dysfunction impacts mitochondrial respiration and mitochondrial oxidative stress responses
Highlighted Article: Condensin II proteins localize to mitochondria, and their depletion results in defects in oxygen consumption rates, changes in ATP levels and inefficient mitochondrial responses to oxidative stress.
Two conserved glycine residues in mammalian and Dictyostelium Rictor are required for mTORC2 activity and integrity
Summary: Two glycine residues are essential for the mTORC2 activity and integrity in organisms that are distantly related, suggesting they have a conserved role in mTORC2 assembly and functioning.
Role for the splicing factor TCERG1 in Cajal body integrity and snRNP assembly
Highlighted Article: The results suggest a new role for TCERG1 in the formation of Cajal bodies and the biogenesis of snRNPs, which may have a functional consequence for pre-mRNA processing.
Vac8 spatially confines autophagosome formation at the vacuole in S. cerevisiae
Highlighted Article: Vac8 tethers the phagophore assembly site to the vacuole, which creates a confined space for autophagosome biogenesis and coordinates autophagosome formation with vacuolar fusion.
Spatial integration of mechanical forces by α-actinin establishes actin network symmetry
Highlighted Article: In the absence of α-actinin, a cross-linker of actin filaments, the symmetry of the cellular actin architecture is no longer in accordance with the geometry of extracellular cues.
JCS Journal Meeting 2023: Imaging Cell Dynamics
Our 2023 Journal Meeting on ‘Imaging Cell Dynamics’ will be held from 14-17 May 2023 in Lisbon, Portugal. Due to popular demand, we can currently only accept applications for online attendance. Apply now to attend this meeting virtually. Registration deadline: 31 March.
Call for papers: Cell and Tissue Polarity
We are welcoming submissions for our next special issue, which will focus on ‘Cell and tissue polarity’ and will be guest edited by David Bryant. Submission deadline: 15 July.
Editorial: Publishing where it matters
Editor-in-Chief Michael Way outlines Journal of Cell Science’s plans for the upcoming year and introduces Seema Grewal as our new Executive Editor.
preLights 5th Birthday webinar
preLights, our preprint highlighting service, is celebrating its 5th birthday this year. To mark the occasion, join us online on 14 March 2023 at 16:00 GMT for a discussion, led by four preLights alumni, on how to identify and navigate the challenges and opportunities while shaping your career as an early-career researcher.
Cell Scientists to Watch
As a community-focused journal, Journal of Cell Science is keen to support the next generation of cell biologists. Check out Cell Scientists to Watch, our interview series featuring talented researchers who have recently set up their own labs.