CELL SCIENCE AT A GLANCE
Summary: This Cell Science at a Glance article discusses how membrane-less compartments in the nucleus are formed by phase separation and help to organize and regulate nuclear functions.
A homeostatic mechanism rapidly corrects aberrant nucleocytoplasmic ratios maintaining nuclear size in fission yeast
Summary: Nuclear size homeostasis is achieved by a rapid correction mechanism modulating nuclear growth rate in growing fission yeast cells.
Yap induces osteoblast differentiation by modulating Bmp signalling during zebrafish caudal fin regeneration
Summary: Yap regulates, in a non-cell-autonomous manner, Bmp signalling activation in osteoprogenitors, thereby promoting osteoblast differentiation and proper bone formation during zebrafish caudal fin regeneration.
Highlighted Article: A pool of centriolar γ-tubulin and/or α/β-tubulins anchor MICAL-L1 to the centriole, where it might recruit EHD1 to promote ciliogenesis.
Condensin II protein dysfunction impacts mitochondrial respiration and mitochondrial oxidative stress responses
Highlighted Article: Condensin II proteins localize to mitochondria, and their depletion results in defects in oxygen consumption rates, changes in ATP levels and inefficient mitochondrial responses to oxidative stress.
Two conserved glycine residues in mammalian and Dictyostelium Rictor are required for mTORC2 activity and integrity
Summary: Two glycine residues are essential for the mTORC2 activity and integrity in organisms that are distantly related, suggesting they have a conserved role in mTORC2 assembly and functioning.
Highlighted Article: The results suggest a new role for TCERG1 in the formation of Cajal bodies and the biogenesis of snRNPs, which may have a functional consequence for pre-mRNA processing.
Highlighted Article: Vac8 tethers the phagophore assembly site to the vacuole, which creates a confined space for autophagosome biogenesis and coordinates autophagosome formation with vacuolar fusion.
Highlighted Article: In the absence of α-actinin, a cross-linker of actin filaments, the symmetry of the cellular actin architecture is no longer in accordance with the geometry of extracellular cues.