Issues

Summary: A summary of how extracellular and intracellular signals feed into the mTOR pathway, how the lysosome acts as an mTOR signaling hub, and how downstream signaling controls autophagy and lysosome biogenesis.

Summary: A Review of recent developments in understanding the major cell-autonomous stress-responsive transcriptional regulatory pathways, including the activation of enhancers and complex changes in chromatin organization.

Summary: Talin requires cooperative Rap1 binding to its F0 and F1 domains and lipid binding to the F2 domain for its recruitment to adhesion sites to trigger integrin activation.

Summary: After prolonged quiescence, fission yeast cell populations switch state to immobilise subcellular components much more profoundly than cells experiencing acute energy depletion.

Highlighted Article: P-cadherin-induced decorin expression allows collagen fiber alignment and subsequent activation of the β-PIX/Cdc42 axis to promote directional collective cell migration.

Highlighted Article: Phospho-regulation of the INCENP STD motif acts as a novel switch that is key to Aurora B activity modulation, chromosome alignment and cytokinesis.

Highlighted Article: Cyclin E is targeted by Cul3 for proteasomal degradation via a newly identified degron located within the N-terminal domain of cyclin E, a region that is often missing in cancer cells.

Summary: GRASP55 is highly acetylated on lysine 50 during mitosis, and its deacetylation by SIRT2 at mitotic exit promotes Golgi assembly through facilitating GRASP55 self-interaction.

Highlighted Article: Functionalized GFP-binding nanobodies (dongles) can extend the use of GFP-tagged proteins. Here, dongles that allow knocksideways are demonstrated, but they are limited by perturbation of the target protein caused by dongle binding alone.

Summary: An easy dry-ice-free method of sending cultured cells across the globe at ambient temperatures.