Issues

Summary: Adaptor protein complexes select cargo for transport between subcellular compartments. Disease-causing mutations identified in each of the five complexes cause certain membrane proteins to be mislocalised.

Summary: This article reviews current literature on cargoes contained within extracellular vesicles (EVs) and the emerging theory of how they support immune suppression in cancer.

Summary: Multiple subunits of AMPK are phosphorylated by cyclin-dependent kinase 1 during mitosis. Phosphorylation of AMPK regulates proper mitosis and links to paclitaxel chemosensitivity.

Summary: VEGFR2 docked to shed Sdc1 activates CXCR4- and VLA-4-dependent tumor cell migration. Blocking VEGFR2 docking prevents this migration while stimulating the migration of tumor-targeting T cells and NK cells.

Summary: The immunophilin FKBP52 directly interacts with TRPC3. A loss of interaction with the functionally intact FKBP52 results in an increased TRPC3 activity and enhanced enlargement of cardiomyocytes.

Highlighted Article: Insufficient expression of several enzymes involved in mannose glycosylation is responsible for defective NIS protein trafficking and localization in breast cancer cell.

Summary: The lncRNA hsrω regulates the arginine methyltransferases type I and II to modify the human FUS RNA-binding protein, recombinantly expressed in flies, in a fashion that controls both its cellular localization and homeostasis.

Highlighted Article: Dynamic analysis of live neurons modelling Alzheimer's disease (AD)-like amyloid pathology shows loosened mitochondria-ER contacts (MERC), providing a novel perturbation of the MERC axis in AD.

Highlighted Article: Discovery of Tox4 as a mediator of reprogramming of mouse embryonic fibroblasts to the induced pluripotent and neuronal fate.

Summary: Loss of PINK1 kinase function, as occurs in Parkinson's disease, causes impaired activation of Akt as a result of defects in phospholipid PI(3,4,5)P₃ regulation.

Summary: Blockade of the SUMO pathway inhibits tumorigenesis through two different mechanisms: (i) stimulation of autophagy-mediated cancer cell death via TRIB3 upregulation; and (ii) inhibition of invasiveness via abrogation of RAC1 SUMOylation.

Summary: A specifically engineered synthetic hydrogel platform that supports epithelial tubular morphogenetic programs was used to identify extracellular matrix biophysical and biochemical properties required for epithelial tubulogenesis.

Highlighted Article: Two emerin proteins in Drosophila regulate the abundance of Klarsicht at the nucleus, which is necessary for the proper movement of myonuclei.

Summary: TGFβ, a master regulator of fibrosis, epigenetically represses anti-fibrotic gene expression via HDACs to promote fibroblast activation.

Highlighted Article: GRIN2B mutations cause ASD, but the pathogenic mechanisms remained unknown. We show that ASD-specific GRIN2B mutations interfere with NMDA receptor trafficking and lead to reduced dendrite elongation and branching.

Highlighted Article: Simultaneous time-lapse imaging of invadopodia and FUCCI markers in 2D, spheroids and tumors in vivo demonstrates that cancer cells invade preferentially during the G1 phase of the cell cycle.

Summary: Cytosolic annexin A5 regulates the particle binding step of clearance phagocytosis by increasing levels of apical surface αvβ5 integrin receptors of retinal pigment epithelial cells.

Summary: Establishment of a new transgenic zebrafish line with knock-in GFP-G3BP1 to visualize stress granule dynamics in live animals in real time.