Issues

Summary: Linear ubiquitin chains are crucial modulators of innate and adaptive immune responses that act by regulating inflammatory and cell death signalling.

Summary: A critical review of the current knowledge on the cellular processes involved in lysosomal storage disorders. How understanding of these rare disorders could be applied to more common diseases is discussed.

 Summary: Chk1 regulates cell cycle progression by inducing Cdc25A degradation in the absence of exogenous DNA damage.

Summary: CAF1 is a Notch signaling activator in Drosophila wing imaginal disc development. Unexpectedly, this study reveals that CAF1 silences Notch signaling to sustain Drosophila follicle cell proliferation.

Summary: EGCG inhibits OMA1 self-cleavage and attenuates OPA1 cleavage, suggesting that EGCG can be used to treat IRI.

Summary: Dictyostelium feed by macropinocytosis in a PIP3-dependent manner. Macropinosomes are smaller and fluid uptake is nearly abolished in cells lacking either PI3Ks or the downstream kinases PkbA and PkbR1.

Summary: Depletion of GM130 and p115 in differentiating skeletal muscle cells perturbs the association of the Golgi and ERES, affecting the trafficking of M-cadherin and altering skeletal muscle cell differentiation.

Summary: The important cell cycle kinase Plk1 regulates Hh signaling by phosphorylating and inhibiting Gli1, a downstream transcription factor of Hh signaling pathway.

Summary: Our study reveals that deubiquitylase USP9X is a constituent of centriolar satellites, and functions to maintain centriolar satellite integrity by preventing proteasomal degradation of the core satellite scaffold protein PCM1.

Summary: An interaction between vinculin and an amphipathic helix of vinexin α is required for a conformational change in vinculin and promotion of YAP/TAZ nuclear localization on rigid ECM.

Highlighted Article: Upf1-mediated inhibition of Arc gene expression may contribute to rapid and selective Arc induction in response to vigorous neuronal activity.

Summary: LGI1 is enriched at the axon initial segment of hippocampal neurons with ADAM22 and Kv1 channel proteins, and LGI1 mutations associated with epilepsy prevent its recruitment at that site.

Highlighted Article: The ER membrane protein complex promotes biogenesis of key membrane-bound enzymes responsible for regulation of cholesterol biosynthesis and storage, an important determinant of mammalian cell viability.

Summary: The Clouston syndrome-causing connexin 30 mutant (Cx30-A88V) provides long-term protection against age-related hair cell death and hearing loss in mice.

Summary: The atypical small GTPase RABL2 plays an important role in trafficking of ciliary GPCRs at the ciliary base in mammalian cells.

Summary: Cytosolic complexes of myosin II, cortexillin I and IQGAPs define the assembly and feedback mechanisms of a mechanoresponsive contractility controller.

Highlighted Article: The Drosophila ortholog of Dbf4, Chiffon, binds Gcn5 to form a novel histone acetyltransferase complex that is essential for viability in flies, but is not required for DNA replication.