Cover: Confocal fluorescence image of a collectively invading 3D spheroid, comprising follower cells isolated from the H1299 non-small cell lung cancer cell line. Green cells (90% of the spheroid) are unmodified follower cells, and magenta cells (10% of the spheroid) are follower cells engineered to express ARP3 K240R, a mutant found to be present in H1299 leader cells but absent in follower cells. See article by E. L. Zoeller et al. (jcs231514).
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CELL SCIENTISTS TO WATCH
Microtubules at focal adhesions – a double-edged sword
Summary: A Review of the direct and indirect crosstalk between focal adhesions and microtubules.
Tissue-specific roles of p73 in development and homeostasis
Summary: While p73, a member of the p53 family, has functions in cancer, p73 knockout mice also exhibit a diverse non-cancerous phenotype that has uncovered an astonishing breadth of cellular and molecular functions.
Chemically induced neurite-like outgrowth reveals a multicellular network function in patient-derived glioblastoma cells
Summary: ROCK inhibition significantly promotes the outgrowth of cell projections in glioblastoma multiforme stem-like models, which in turn enabled the de novo formation of multicellular networks.
Modulation of TOR complex 2 signaling by the stress-activated MAPK pathway in fission yeast
Summary: Independently of its interaction with the Sin1 subunit of TORC2, stress-activated MAPK positively regulates TORC2, constituting a signaling network for stress survival in fission yeast.
Tetraspanin CD151 and integrin α3β1 contribute to the stabilization of integrin α6β4-containing cell-matrix adhesions
Highlighted Article: In keratinocytes, CD151 controls the stability of adhesion structures with a distinct molecular composition with hemidesmosome and tetraspanin features.
Basal-type lumenogenesis in extraembryonic endoderm stem cells models the early visceral endoderm
Summary: This study reveals a stepwise process of basal-type lumenogenesis by extraembryonic endoderm stem cells in vitro and proposes a physiological interpretation.
COMMD1 and PtdIns(4,5)P2 interaction maintain ATP7B copper transporter trafficking fidelity in HepG2 cells
Summary: Quantitative analysis of 3D protein colocalization defines the cellular function of COMMD1 in maintenance of ATP7B copper transporter trafficking fidelity and the importance of PtdIns(4,5)P2 in this action.
Genetic heterogeneity within collective invasion packs drives leader and follower cell phenotypes
Summary: Image-guided capture and sequencing of invasive cancer cells reveals novel leader- and follower-specific gene mutations, highlighting an important relationship between genomic and phenotypic heterogeneity during collective invasion.
Local inhibition of rRNA transcription without nucleolar segregation after targeted ion irradiation of the nucleolus
Summary: Highly localized damage induced in nucleoli by carbon ion irradiation at the microbeam SNAKE only locally inhibits rRNA transcription, but does not cause nucleolar segregation.
Cross-talk between TGF-β and PDGFRα signaling pathways regulates the fate of stromal fibro–adipogenic progenitors
Summary: TGF-β signaling in skeletal muscle mesenchymal stromal cells suppresses PDGFRα expression and compromises PDGFRα-dependent signaling, resulting in impaired TGF-β-mediated responses.
Mechanical stress induces a scalable switch in cortical flow polarization during cytokinesis
Summary: When the C. elegans embryo experiences mechanical stress during its first cell division, the direction of cortical flow needs to change so cytokinesis can be completed.
SH3YL1 cooperates with ESCRT-I in the sorting and degradation of the EGF receptor
Summary: A phosphoinositide-binding protein SH3YL1 binds to an ESCRT-I component Vps37B and plays an indispensable role in the degradative endosomal sorting of EGFR.
Differential requirements for the EF-hand domains of human centrin 2 in primary ciliogenesis and nucleotide excision repair
Highlighted Article: Mutagenesis analysis of human centrin 2 reveals a separation of functions whereby centrin 2 that is defective in calcium binding can support nucleotide excision repair but not primary ciliogenesis.
The RBG-1–RBG-2 complex modulates autophagy activity by regulating lysosomal biogenesis and function in C. elegans
Highlighted Article: Loss of function of the RBG-1-RBG-2 complex promotes lysosomal biogenesis and function, and also ameliorates the autophagy defect caused by mutations in the Vici syndrome gene EPG5.
Mitochondrial Alkbh1 localizes to mtRNA granules and its knockdown induces the mitochondrial UPR in humans and C. elegans
Summary: The Alkbh1 enzyme has an impact on mitochondrial respiration, but not on mitochondrial structure in human cells. Its knockdown induces mitochondrial UPR in human cells and C. elegans.
Correction: Arg tyrosine kinase modulates TGF-β1 production in human renal tubular cells under high-glucose conditions (doi:10.1242/jcs.183640)
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