Issues

Summary: Cell–cell fusion is promoted by invasive protrusions and mechanosensory responses at the asymmetric fusogenic synapse.

Summary: A Review of contributions of force-generating mechanisms, acting through different microtubule populations, to chromosome segregation in human cells.

Summary: Cx43 plays a key role in wound healing and Cx43 modulators are used in clinical trials. We tested the importance and roles of specific Cx43 phosphorylation sites during wound repair.

Summary: Proteolysis mediated by the anaphase-promoting complex is not sufficient for inducing anaphase I in mouse oocytes and Cep55-dependent phosphoinhibition of cyclin-dependent kinase 1 is also required.

Highlighted Article: Depletion of smooth septate junction-associated proteins from enterocytes in the Drosophila adult midgut results in intestinal hypertrophy accompanied by accumulation of morphologically aberrant enterocytes and increased stem cell proliferation.

Highlighted Article: In cultured neurons, Nup358 is present at the nuclear rim associated with nuclear pore complex proteins, as well in the cytoplasm and the axon initial segment (AIS), dependent on the AIS scaffold Ankyrin-G.

Summary: Longer collagen fibers promote collective cell streaming on soft gels via mechanoactivation, velocity coordination, and cell–cell cooperation. Coating of collagen fibers of tunable lengths is enabled by aldehyde-functionalized polyacrylamide hydrogels.

Summary: Keratin 8 interacts with p38 MAPK via a specific docking site and modulates formation of the p38-Hsp70 complex, which regulates the subcellular localization of p38 MAPK.

Summary: Phosphorylation of importin-α1 by cyclin-dependent kinase 1 provides spatial and temporal control of mitotic spindle assembly through the release of spindle-assembly factors from inhibitory complexes during mitosis.

Highlighted Article: Mitochondrial depolarization induces Arp2/3 complex-dependent actin clouds that restrain OMA1-induced mitochondrial shape changes. A distinct actin network stimulates calcium-induced mitochondrial fission.

Summary: The kinesin-8 Klp5-Klp6 relies on tailbox motifs for processivity, thereby inducing catastrophe and destabilising MTs. Klp5-Klp6 and Dis1/TOG, acting in concert, impose an upper spindle length for viable chromosome segregation in fission yeast.