Issues

Summary: Endothelial cell–cell contacts protect tissues from edema and uncontrolled invasion of inflammatory cells. Here, we discuss the emerging role of ubiquitylation of specific proteins controlling endothelial integrity and inflammation.

Summary: Cells use sophisticated control systems to drive cell behaviors. The mechanobiome senses inputs, establishes and maintains system setpoint and integrates different cellular processes with mechanics to ensure robustness against disturbances.

Highlighted Article: The endocytic adaptor protein Bbc1 regulates endocytosis in fission yeast via its association with the myosin-I tail, thereby limiting association of the yeast WASp with myosin-1 at the base of endocytic invaginations.

Highlighted Article: Circulating tumor cell clusters spread throughout the body by using a unique method to exit blood vessels, which grants the tumor cells an increased ability to form secondary tumors.

Summary: A quantification of the dynamics of monoallelic, antisense and poly(A)− expression, distinction between poly(A)+ and poly(A)− antisense transcripts, and bimorphic transcription during neural differentiation.

Highlighted Article: DCAF8 is a novel MuRF1 interaction partner that promotes muscle atrophy and thereby links CRL4 ubiquitin ligase complexes to the loss of muscle mass.

Summary: In light of cisternal maturation, Golgi stacking needs to be reversible. The evolutionarily conserved GRIP domain golgin PpImh1 is implicated in such reversible cisternal stacking, suggesting a novel, but conserved mechanism.

Summary: The Mtb Beijing/K-specific protein PPE39 induces maturation of dendritic cells via TLR4, promoting polarization of naïve CD4⁺ T cells towards the Th1-cell phenotype.

Summary: The Joubert syndrome-causing protein, Ahi1, acts as a gatekeeper in regulating primary cilia protein composition and length. Ahi1 also regulates Arl13b stability, Shh signaling and cell migration.

Highlighted Article: A mechanical induction pathway of macropinocytosis is elicited by acute decrease of plasma membrane tension and followed by lipid/PLD2 nanodomain disintegration, PLD2 activation and PA production.

Summary: ATP11C-b, a C-terminal splice variant of the PS-flippase ATP11C, localizes to a limited region of the plasma membrane in polarized cells, and LLXY residues are critical for the localization.

Summary: Intracellular and extracellular signals affecting focal adhesions regulate the membrane localization of K_ir2.1 channels to profoundly influence electrophysiology of excitable cells, including cardiomyocytes.

Summary: In humans, sirtuin 7 plays a key role in the synthesis of ribosomal subunits by controlling critical endonucleolytic cleavages of precursor ribosomal RNAs.