Issues
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Cover image
Cover Image
Cover: High frame rate three-dimensional views of the unicellular human parasite Trypanosoma brucei while swimming. Each image shows the same cell at different 3D orientations (left to right) at different times (top to bottom), where colour represents different focal planes (red to blue). See article by B. J. Walker and R. J. Wheeler (jcs231795).
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RESEARCH HIGHLIGHTS
STICKY WICKET
FIRST PERSON
MEETING REPORT
CELL SCIENCE AT A GLANCE
Intramembrane proteolysis at a glance: from signalling to protein degradation
Summary: In this Cell Science at a Glance article and the accompanying poster, we review the current knowledge on the function of intramembrane proteolysis in mammalian cells.
HYPOTHESIS
Dynamic cell–cell adhesion mediated by pericellular matrix interaction – a hypothesis
Summary: A discussion of the theory that pericellular matrices behave like hydrogels whose interactions can generate the entire 1000-fold range of observed cell–cell adhesion strengths.
REVIEW
Ubiquitin recognition in endocytic trafficking – with or without ESCRT-0
Summary: ESCRT-0 is a heterodimeric ubiquitin receptor involved in endosomal trafficking, that has been acquired in opisthokonts and missing in other organisms. We discuss how other multicellular organisms, such as plants, recognise ubiquitylated cargoes.
SHORT REPORT
High-speed multifocal plane fluorescence microscopy for three-dimensional visualisation of beating flagella
Summary: A new 3D fluorescence microscopy-based method allows analysis of the high speed beating of cilia and flagella, with potential to answer open questions about Leishmania and Trypanosoma 3D motility.
RESEARCH ARTICLES
Dissection of GTPase-activating proteins reveals functional asymmetry in the COPI coat of budding yeast
Highlighted Article: The regulatory domain of the COPI-associated ArfGAP Glo3 can stabilize the COPI coat. GTP hydrolysis is necessary to resolve the stabilised state. This mechanism is regulated by phosphorylation.
CXCL2 attenuates osteoblast differentiation by inhibiting the ERK1/2 signaling pathway
Highlighted Article: The inflammatory chemokine CXCL2 has an important role in the pathogenesis of osteoporosis and attenuates osteogenesis by inhibiting differentiation of osteoblasts through ERK1/2 signaling.
Serotonin receptor oligomerization regulates cAMP-based signaling
Highlighted Article: A FRET-based method is used to assess the impact of GPCR hetero-oligomerization on downstream signaling and contributes to the identification of the stoichiometry of endogenously expressed GPCRs under physiological conditions.
Trans-endocytosis elicited by nectins transfers cytoplasmic cargo, including infectious material, between cells
Highlighted Article: Characterization of a newly discovered nectin trans-endocytosis processes that not only transfers cell surface proteins but also cytoplasmic proteins. It can also transfer measles virus ribonucleocapsids, extending tropism to neurons.
Depletion of phosphatidylinositol 4-phosphate at the Golgi translocates K-Ras to mitochondria
Summary: Overexpression of the mitochondrial targeting sequence of ATP5G1 perturbs glucose metabolism, and translocates K-Ras to mitochondria and phosphatidylserine to endomembranes, through regulation of PI4P content at the Golgi.
Glucocorticoids delay RAF-induced senescence promoted by EGR1
Summary: In human fibroblasts, glucocorticoids induce a delay or bypass entry into senescence induced by oncogenic B-RAF-V600E. This senescence is promoted by EGR1 through transcriptional activation of the key cell cycle inhibitors CDKN1A and CDKN2B.
MKL1 overexpression predicts poor prognosis in patients with papillary thyroid cancer and promotes nodal metastasis
Summary: MKL1 expression is elevated in patients with papillary thyroid carcinoma (PTC) with nodal metastasis, promoting the migration and invasion of human PTC cells by targeting the TGF-β–Smad3–MMP2 signaling pathway.
Myosin V regulates synaptopodin clustering and localization in the dendrites of hippocampal neurons
Summary: The spine apparatus is assembled locally in dendrites. This process, which relies on the presence of synaptopodin and F-actin, is disrupted by interfering with myosin V activity.
The Chlamydomonas flagellar membrane glycoprotein FMG-1B is necessary for expression of force at the flagellar surface
Highlighted Article: The Chlamydomonas flagellar membrane glycoprotein FMG-1B is responsible for coupling the motor machinery of IFT to an extracellular substrate to generate flagellar surface motility (whole-cell gliding and microsphere movement).
PI3Kβ is selectively required for growth factor-stimulated macropinocytosis
Summary: There is a highly specific requirement for a single PI3K isoform, PI3Kβ, during growth factor-stimulated macropinocytosis and constitutive macropinocytosis in PTEN-null tumor cells.
Synergistic repression of thyroid hyperplasia by cyclin C and Pten
Summary: Cyclin C and the Pten phosphatase combine to restrict thyroid tissue hyperplasia by maintaining levels of the p21 and p53 tumor suppressors through a post-transcriptional mechanism.
The RNA-binding protein QKI controls alternative splicing in vascular cells, producing an effective model for therapy
Summary: The RNA-binding protein QKI isoforms hold key roles in alternative splicing facilitating the production of vascular cells for therapy and disease modelling.
PUBLISHER'S NOTE
Expression of Concern: Inhibition of TPO-induced MEK or mTOR activity induces opposite effects on the ploidy of human differentiating megakaryocytes (doi:10.1242/jcs.02784)
2024 Journal Meeting 'Diversity and Evolution in Cell Biology'

Registration is open for our 2024 Journal Meeting Diversity and Evolution in Cell Biology, which aims to bring together evolutionary biologists and cell biologists investigating diverse aspects of cellular physiology. Early-bird deadline is 19 January 2024.
FocalPlane image competition winner: Rebecca Simkin

We are delighted to announce that the winner of the 2023 FocalPlane image competition is Rebecca Simkin. Rebecca’s image, ‘Neuromuscular junctions’, depicts four NMJs in a lumbrical muscle, located in the hind paw of a wildtype mouse. Read the full interview here.
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