Issues
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Cover image
Cover Image
Cover: Cilia and basal bodies in a Tetrahymena thermophila cell. Immunofluorescence image of a wild-type T. thermophila cell stained for cilia (yellow, α-tubulin) and basal bodies (cyan, centrin). See article by A. D. Junker et al. (jcs233726).
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RESEARCH HIGHLIGHTS
STICKY WICKET
FIRST PERSON
MEETING REPORT
HYPOTHESIS
The conserved ancestral signaling pathway from cilium to nucleus
Summary: Here, we propose a hypothesis to answer the question of why so many signaling molecules that work in the nucleus are also found in the primary cilium.
SHORT REPORT
Colocation of Tpm3.1 and myosin IIa heads defines a discrete subdomain in stress fibres
Summary: Super-resolution and electron microscopy are used to show that tropomyosin Tpm3.1 is periodically distributed along stress fibres and linked to the organisation of myosin II motors.
RESEARCH ARTICLES
TNAP limits TGF-β-dependent cardiac and skeletal muscle fibrosis by inactivating the SMAD2/3 transcription factors
Summary: Tissue non-specific alkaline phosphatase (TNAP) negatively regulates TGF-β signalling and might represent a mechanism to limit fibrosis through SMAD dephosphorylation.
Microtubule glycylation promotes attachment of basal bodies to the cell cortex
Highlighted Article: Motile cilia are positioned at the cell cortex by basal bodies (BB). Tubulin glycylation promotes elongation of BB-associated microtubules and structural attachment of BBs to the cortical cytoskeleton.
Parcas is the predominant Rab11-GEF for rhodopsin transport in Drosophila photoreceptors
Highlighted Article: Parcas, a Rab11-GEF, localizes Rab11 onto Golgi-associated recycling endosomes and post-Golgi vesicles in fly photoreceptors. Cytoplasmic rhodopsin accumulation seen upon Parcas deficiency phenocopies Rab11 knockdown.
Cytocortex-dependent dynamics of Drosophila Crumbs controls junctional stability and tension during germ band retraction
Summary: The dynamics of the evolutionarily conserved polarity regulator Crumbs at the plasma membrane is important for modulating junctional stability and tension during embryonic development of Drosophila.
Spatiotemporal dissection of the trans-Golgi network in budding yeast
Highlighted Article: The TGN displays two sub-stages of maturation: ‘early TGN’, when retrograde traffic is received, and ‘late TGN’, when transport carriers are produced. At the late TGN, various coat/adaptor proteins exhibit distinct assembly dynamics.
CHIR-99021 regulates mitochondrial remodelling via β-catenin signalling and miRNA expression during endodermal differentiation
Summary: CHIR-99021 plays a role in mitochondrial structure and function remodelling through β-catenin signalling activation and miRNA inhibition during multipotent definitive endodermal differentiation.
Extracellular Hsp90α and clusterin synergistically promote breast cancer epithelial-to-mesenchymal transition and metastasis via LRP1
Summary: Clusterin is identified to interact with extracellular Hsp90α and modulate its pro-metastatic function through increasing the binding affinity of eHsp90α and LRP1.
Acylpeptide hydrolase is a novel regulator of KRAS plasma membrane localization and function
Summary: APEH is a novel regulator of the plasma membrane localization and function of KRAS. Therefore, APEH is a potential drug target for KRAS-dependent human cancers.
TOOLS AND RESOURCES
Real-time imaging of integrin β4 dynamics using a reporter cell line generated by Crispr/Cas9 genome editing
Summary: Crispr/Cas9 technology was used to tag an allele of the β4 integrin; reporter cells harboring this allele are useful for obtaining new insight into integrin β4 dynamics during cell migration.
Call for papers - Cilia and Flagella: from Basic Biology to Disease
We are welcoming submissions for our upcoming special issue: Cilia and Flagella: from Basic Biology to Disease. This issue will be coordinated by two Guest Editors: Pleasantine Mill (University of Edinburgh) and Lotte Pedersen (University of Copenhagen). Extended submission deadline: 31 March 2025.
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about Journal of Cell Science’s journey and explore the history of each of our sister journals: Development, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.
Introducing our new Associate Editors
In this Editorial, JCS Editor-in-Chief Michael Way welcomes five new Associate Editors to the JCS team. These Associate Editors will expand our support for the wider cell biology community and handle articles in immune cell biology, proteostasis, imaging and image analysis, plant cell biology, and stem cell biology and modelling.
Diversity of microtubule arrays in animal cells at a glance
In this Cell Science at a Glance article, Emma van Grinsven and Anna Akhmanova provide an overview of the diverse microtubule arrays present in differentiated animal cells and discuss how these arrays form and function.
JCS-FocalPlane Training Grants
Early-career researchers - working in an area covered by JCS - who would like to attend a microscopy training course, please apply. Deadline dates for 2025 applications: 7 March 2025 (decision by week commencing 21 April 2025) and 6 June 2025 (decision by week commencing 28 July 2025).
