Issues

Summary: An introduction to the molecular mechanisms of cell competition, and the biological relevance of competition in the nervous system in the context of AD.

Summary: This Review highlights some of the recent findings regarding the roles of extracellular vesicles in physiological and pathological processes.

Summary: Disruption of zDHHC15 function in primary hippocampal cultures reduces dendritic outgrowth, spine maturation, excitatory synapse density and trafficking of PSD-95 into dendrites.

Highlighted Article: Lipid droplets reorganise in mouse eggs, and maintain a dynamic balance of oxidation of fatty acids and pyruvate.

Summary: VGLL3 interacts with TEAD transcription factors to direct expression of crucial muscle regulatory genes and contribute to the control of skeletal myogenesis.

Summary: A novel fluorescent pulse-chase technology is used to demonstrate that CgB regulates granule budding in the islet β-cell.

Highlighted Article: Although unnecessary for NHEJ in irradiated cells, DNA-PKcs serves a critical role after DNA repair by downregulating DNA damage signaling to protect cells from mitotic slippage and senescence.

Highlighted Article: Centrin2 from the human parasite Toxoplasma gondii is incorporated into multiple cytoskeletal structures to serve distinct functions in invasion and replication that are required for its survival.

Summary: A strategy to decipher which tail-anchored proteins do (as opposed to can or must) use the TRC pathway in intact cells generates a comprehensive list of human TRC40 clients.

Summary: Formin Cdc12 actin cable formation is inhibited by increased ergosterol levels in fission yeast, resulting in defective cytokinetic ring assembly and division plane position.

Summary: TRPC1 modulates Ca²⁺ entry, which is essential in adipocyte differentiation and adiponectin secretion, through facilitating SNARE complex formation, thereby maintaining metabolic homeostasis.

Highlighted Article: Biomechanical integration of apical constriction and interkinetic nuclear migration in the pseudostratified epithelium of the mammalian spinal neural tube requires the actomyosin regulator Rock.