CELL SCIENTISTS TO WATCH
Summary: An introduction to the molecular mechanisms of cell competition, and the biological relevance of competition in the nervous system in the context of AD.
Summary: Disruption of zDHHC15 function in primary hippocampal cultures reduces dendritic outgrowth, spine maturation, excitatory synapse density and trafficking of PSD-95 into dendrites.
Dynamic label-free imaging of lipid droplets and their link to fatty acid and pyruvate oxidation in mouse eggs
Highlighted Article: Lipid droplets reorganise in mouse eggs, and maintain a dynamic balance of oxidation of fatty acids and pyruvate.
Summary: VGLL3 interacts with TEAD transcription factors to direct expression of crucial muscle regulatory genes and contribute to the control of skeletal myogenesis.
Chromogranin B regulates early-stage insulin granule trafficking from the Golgi in pancreatic islet β-cells
Summary: A novel fluorescent pulse-chase technology is used to demonstrate that CgB regulates granule budding in the islet β-cell.
Repair-independent functions of DNA-PKcs protect irradiated cells from mitotic slippage and accelerated senescence
Highlighted Article: Although unnecessary for NHEJ in irradiated cells, DNA-PKcs serves a critical role after DNA repair by downregulating DNA damage signaling to protect cells from mitotic slippage and senescence.
Centrin2 from the human parasite Toxoplasma gondii is required for its invasion and intracellular replication
Highlighted Article: Centrin2 from the human parasite Toxoplasma gondii is incorporated into multiple cytoskeletal structures to serve distinct functions in invasion and replication that are required for its survival.
Summary: A strategy to decipher which tail-anchored proteins do (as opposed to can or must) use the TRC pathway in intact cells generates a comprehensive list of human TRC40 clients.
Increasing ergosterol levels delays formin-dependent assembly of F-actin cables and disrupts division plane positioning in fission yeast
Summary: Formin Cdc12 actin cable formation is inhibited by increased ergosterol levels in fission yeast, resulting in defective cytokinetic ring assembly and division plane position.
Ca2+ entry via TRPC1 is essential for cellular differentiation and modulates secretion via the SNARE complex
Summary: TRPC1 modulates Ca2+ entry, which is essential in adipocyte differentiation and adiponectin secretion, through facilitating SNARE complex formation, thereby maintaining metabolic homeostasis.
Rho kinase-dependent apical constriction counteracts M-phase apical expansion to enable mouse neural tube closure
Highlighted Article: Biomechanical integration of apical constriction and interkinetic nuclear migration in the pseudostratified epithelium of the mammalian spinal neural tube requires the actomyosin regulator Rock.