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RESEARCH HIGHLIGHTS

STICKY WICKET

FIRST PERSON

CELL SCIENTISTS TO WATCH

CELL SCIENCE AT A GLANCE

Summary: In this Cell Science at a Glance article and the accompanying poster, we review the current knowledge on the dynamics, organization and regulation of microtubule minus ends.

REVIEW

Summary: A summary of the current knowledge on chemoattractant gradient detection in yeast, which occurs at a motile polarity patch. It further describes the stabilization and hyperpolarization process underlying cell fusion.

SHORT REPORT

Summary: Active cell repulsion, driven by ephrin and ERK signalling, is required for fibrosarcoma cells to segregate from epithelial cells in culture.

RESEARCH ARTICLES

Summary: Fluid shear stress causes nuclear shrinkage through a Ca2+-dependent signaling pathway, and the Piezo1 channel is a key element for transmitting the shear force input to nuclei.

Highlighted Article: Characterization of a new endosomal complex, comprising GGA2 and RAB13, that promotes recycling of endocytosed active β1-integrin to the plasma membrane, to support the migration of breast cancer cells.

Highlighted Article: The embryophyte-specific protein MACET4 is a cell cycle-regulated protein that localizes to the phragmoplast distal zones and nucleates microtubules in vitro.

Summary: Loss of the RhoGAP protein DLC3, a putative tumor suppressor, enhances fast recycling of the metalloproteinase MT1-MMP and cellular matrix-degrading activity.

Summary: By using flow systems, magnetic tweezers and knockout mice, we show that β1 integrin is activated by unidirectional hemodynamic shear force leading to Ca2+ signalling and cell alignment, but it is not activated by bidirectional force.

Summary: LRRK1 phosphorylates Rab7 at S72. This increases the association of Rab7 with its effector RILP, resulting in enhanced minus-end transport of EGFR-containing endosomes through a dynein-dependent mechanism.

Highlighted Article: GemC1 within the trimeric GemC1–E2F5–p73 complex regulates transcriptional activation of p73 and modifies the chromatin organization of the p73 locus in order to generate multiciliated cells.

Summary: DnaJB6 is a novel RanGTP-regulated protein that appears to play an important role in dynein-dependent spindle organization and spindle assembly.

Summary: A single amino acid change renders meprin β more active at the cell surface and reduces its ADAM17-mediated shedding.

Summary: Peroxisomes regulate mitochondrial morphology through a Drp1-dependent mechanism and suppress the execution of stress-induced mitochondrion-dependent apoptosis.

Highlighted Article: Selection for tumour cells that efficiently pass through narrow diameter microporous membranes reveals a prominent role for MAPK signalling in regulating cell elasticity.

Summary: Muscarinic receptor stimulation in adrenal medullary cells induces excitation and catecholamine secretion, in part due to insertion of TRPC1–TRPC4 channels into the cell membrane.

TOOLS AND RESOURCES

Summary: Optimization of the self-assembling split-GFP system and the assessment of protein-targeting specificity to endosymbiotic organelles in plant cells, utilizing a Golden Gate-based vector toolkit.

Summary: This work describes a simple and effective assay to screen for protein-protein interactions in yeast by using proximity-dependent biotinylation.

PUBLISHER'S NOTE

CORRECTION

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