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Summary: We review how spatial regulation of the small GTPase Cdc42 promotes polarity and polarized morphogenesis of the plasma membrane, with a focus on the epithelial cell type.

Summary: The multitasking tethering complexes CORVET, CHEVI and HOPS are major organizers of the endocytic pathway. This Review combines current knowledge on their roles in membrane trafficking and diseases.


Summary: The RyR2–P2328S mutation, precipitating potentially fatal arrhythmia in humans, can be attributed to leftward shifts in cytoplasmic Ca2+–dependent RyR2 activation and inactivation in the absence of adrenergic stimulation.

Highlighted Article: FKBP12 is a novel target protein that acts in initiating necroptosis and the related systemic inflammatory response syndrome triggered by tumor necrosis factor.

Summary: The Dkk1–Wnt/β-catenin signaling axis has a crucial role in Dox-induced cardiotoxicity, suggesting a potential therapeutic approach for treatment of cardiomyopathy caused by clinical use of Dox.

Summary: Gap junction protein connexin 43 (GJA1) contributes to breast epithelial polarity by modulating mitotic spindle orientation to prevent multilayering of the epithelium typically associated with tumor onset.

Summary: Midzone localization of γ-TuRC-anchoring protein NEDD1 in anaphase results from phosphorylation at serine 405 by Aurora A, regulating microtubule nucleation during central spindle assembly.

Highlighted Article: Absence of nuclear membrane proteins Lem2 and Bqt4 causes lethal defects associated with loss of the nuclear barrier function; the very-long-chain fatty acid elongase Elo2 rescues such lethal defects.

Highlighted Article: The unresolved question of the route that rhodopsin travels along the cilium to accommodate disk membrane morphogenesis was addressed; it was found to be exclusively plasmalemmal.

Highlighted Article: Apical transcytosis is indispensable for the maintenance of highly polarized CFTR expression by counteracting its basolateral missorting from the secretory and apical endocytic pathways in human bronchial epithelial cells.

Summary: Osteoblast lineage cells directly stimulate osteoclastic bone resorption and promote the aggressive trench-resorption mode by exerting a matrix metalloproteinase-dependent catabolic activity.

Summary: STIM1 Y316 phosphorylation results in SARAF dissociation from STIM1, facilitating its activation and interaction with Orai1, then leading to SOCE activation.

Highlighted Article: Nuclear envelope formation around condensed chromatin excludes cytosolic proteins while nuclear proteins, including the proteasome, are then re-imported by conditional nuclear import mechanisms.

Summary: The highly conserved clathrin light chain A, whose function has been elusive, promotes integrin-mediated signaling, association of clathrin with the WAVE complex, and efficient cell spreading and migration.




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