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RESEARCH HIGHLIGHTS

STICKY WICKET

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REVIEWS

Summary: We review how spatial regulation of the small GTPase Cdc42 promotes polarity and polarized morphogenesis of the plasma membrane, with a focus on the epithelial cell type.

Summary: The multitasking tethering complexes CORVET, CHEVI and HOPS are major organizers of the endocytic pathway. This Review combines current knowledge on their roles in membrane trafficking and diseases.

RESEARCH ARTICLES

Summary: The RyR2–P2328S mutation, precipitating potentially fatal arrhythmia in humans, can be attributed to leftward shifts in cytoplasmic Ca2+–dependent RyR2 activation and inactivation in the absence of adrenergic stimulation.

Highlighted Article: FKBP12 is a novel target protein that acts in initiating necroptosis and the related systemic inflammatory response syndrome triggered by tumor necrosis factor.

Summary: The Dkk1–Wnt/β-catenin signaling axis has a crucial role in Dox-induced cardiotoxicity, suggesting a potential therapeutic approach for treatment of cardiomyopathy caused by clinical use of Dox.

Summary: Gap junction protein connexin 43 (GJA1) contributes to breast epithelial polarity by modulating mitotic spindle orientation to prevent multilayering of the epithelium typically associated with tumor onset.

Summary: Midzone localization of γ-TuRC-anchoring protein NEDD1 in anaphase results from phosphorylation at serine 405 by Aurora A, regulating microtubule nucleation during central spindle assembly.

Highlighted Article: Absence of nuclear membrane proteins Lem2 and Bqt4 causes lethal defects associated with loss of the nuclear barrier function; the very-long-chain fatty acid elongase Elo2 rescues such lethal defects.

Highlighted Article: The unresolved question of the route that rhodopsin travels along the cilium to accommodate disk membrane morphogenesis was addressed; it was found to be exclusively plasmalemmal.

Highlighted Article: Apical transcytosis is indispensable for the maintenance of highly polarized CFTR expression by counteracting its basolateral missorting from the secretory and apical endocytic pathways in human bronchial epithelial cells.

Summary: Osteoblast lineage cells directly stimulate osteoclastic bone resorption and promote the aggressive trench-resorption mode by exerting a matrix metalloproteinase-dependent catabolic activity.

Summary: STIM1 Y316 phosphorylation results in SARAF dissociation from STIM1, facilitating its activation and interaction with Orai1, then leading to SOCE activation.

Highlighted Article: Nuclear envelope formation around condensed chromatin excludes cytosolic proteins while nuclear proteins, including the proteasome, are then re-imported by conditional nuclear import mechanisms.

Summary: The highly conserved clathrin light chain A, whose function has been elusive, promotes integrin-mediated signaling, association of clathrin with the WAVE complex, and efficient cell spreading and migration.

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