CELL SCIENCE AT A GLANCE
Summary: This Cell Science at a Glance article reviews the intra- and extracellular activities of carbohydrate-binding galectin proteins, and discusses their physiological roles in inflammation, immune response, cell migration, autophagy and signalling.
The makings of the ‘actin code': regulation of actin's biological function at the amino acid and nucleotide level
Summary: We propose a new concept, the actin code, which encompasses the regulation of the essential functions of mammalian actins at the nucleotide level, rather than at the level of amino acids.
Feedback regulation by antagonistic epigenetic factors potentially maintains developmental homeostasis in Drosophila
Summary: A feedback loop involving dynamic shifts of the global chromatin landscape and transcriptional activity is triggered to offset the inductive impact imposed by overexpression of Trx H3K4 methylase in Drosophila.
Summary: RCAN2 is a centriolar protein with roles in ciliary length control and can compensate for loss of function of giantin.
Distinct 3′ UTRs regulate the life-cycle-specific expression of two TCTP paralogs in Trypanosoma brucei
Summary: T. brucei has two TCTP genes that are differentially expressed during the parasite life cycle owing to their different 3′UTRs. TCTP also has a role in regulating cell growth and morphology.
TFIIH localization is highly dynamic during zygotic genome activation in Drosophila, and its depletion causes catastrophic mitosis
Summary: In vivo dynamics during zygotic genome activation of transcription factor II H and the effect of its absence in the early Drosophila embryo.
Acute HSF1 depletion induces cellular senescence through the MDM2-p53-p21 pathway in human diploid fibroblasts
Highlighted Article: HSF1 regulates cellular senescence through the MDM2-p53-p21 pathway in human diploid fibroblasts, which is partly mediated by expression of the putative MDM2 inhibitor DHRS2.
A fragment of adhesion molecule L1 is imported into mitochondria, and regulates mitochondrial metabolism and trafficking
Summary: A transmembrane fragment of the cell adhesion molecule L1 is imported into neuronal mitochondria, and is important for regulation of mitochondrial metabolism, fusion, fission and trafficking.
Complexes of plexin-A4 and plexin-D1 convey semaphorin-3C signals to induce cytoskeletal collapse in the absence of neuropilins
Summary: Sema3C, previously believed to require receptors of the neuropilin family to repel migrating cells, can also repel cells following binding to a complex of plexin-A4 and plexin-D1.
Summary: Spatio-temporal dynamics of MAPK mediate the interaction of fusing Neurospora crassa cells, which communicate by taking turns in signal sending and receiving.
Adenylyl cyclase A mRNA localized at the back of cells is actively translated in live chemotaxing Dictyostelium
Summary: The relay of cAMP signals is essential for streaming during Dictyostelium chemotaxis. We report the dynamic enrichment and translation of the mRNA encoding adenylyl cyclase A at the back of cells during this process.
Summary: Mutant mice harbouring a severe loss-of-function mutation in Gja1, encoding Cx43, that is associated with the human-linked disease oculodentodigital dysplasia, leads to severe hearing loss and central auditory defects.
The Joubert syndrome protein ARL13B binds tubulin to maintain uniform distribution of proteins along the ciliary membrane
Summary: The Joubert syndrome protein ARL13B binds tubulin to maintain uniform distribution of proteins along the ciliary membrane.
Highlighted Article: The nucleoporin Seh1 is essential for the association of both the GATOR2 complex and the nucleoporin Nup153, but not the Nup107 complex, with mitotic chromosomes.
Dual role of the RNA helicase DDX5 in post-transcriptional regulation of myelin basic protein in oligodendrocytes
Summary: The RNA helicase DDX5 is a novel component of heterogeneous complexes containing Mbp mRNA, regulating post-transcriptional expression of MBP levels and isoform ratios in oligodendrocytes.