Issues

Summary: SUMO isopeptidases of the SENP family regulate the SUMO conjugation–deconjugation cycle and, hence, many cellular key functions. Here, we review the current knowledge on function and regulation of SENP proteins.

Summary: We discuss mechanisms on how cells read their own geometry, and the importance of these mechanisms in different physiological contexts.

Summary: De novo assembly of functional actin–tropomyosin filaments in live rodents is investigated. Unlike non-muscle myosin II, tropomyosin is added to the actin filament shortly after nucleation.

Summary: Anti-miRNA-21 oligonucleotides prevent progression of renal fibrosis by blocking the auto-regulatory loop between miR-21, PDCD4 and AP-1 during myofibroblast activation.

Summary: The novel nucleolar protein Puf3 in Plasmodium might have an essential function in biogenesis of the large ribosomal subunit rather than being involved in translational repression of mRNAs.

Summary: Converging pathways regulate adherens junction stability and retention of Bazooka to promote zonula adherens maturation during epithelial cell morphogenesis in Drosophila.

Summary: TRIOBP-1 and the hERG ion channel protein directly interact and colocalize in cardiomyocytes. TRIOBP-1 overexpression affects channel distribution, I_Kr magnitude and the morphology of the action potential.

Highlighted Article: Ki-67 and condensins, which localize to the external surface and the central axis of mitotic chromosomes, respectively, have independent yet cooperative functions in supporting the structural integrity of mitotic chromosomes.

Highlighted Article: A high-throughput flow cytometry assay is used to examine the regulation of macropinocytosis during transitions between feeding modes (macropinocytic and phagocytic) and entry into development in Dictyostelium. Macropinocytosis inhibitors are assessed.

Summary: Connexin hemichannels activated by oxidative stress in lens fiber cells mediate a cell protective mechanism through the uptake of reductants, maintaining lens transparency and homeostasis.

Summary: H2afx and Mdc1 preserve male germ cell genome stability by promoting proper recombination-mediated synapsis, crossover formation and activation of the recombination-dependent checkpoint.

Summary: Hsp110 associates with the proteasome and ensures the efficient delivery of Hsp70 chaperone-associated proteins for proteolysis in the yeast S. cerevisiae.

Summary: E-cadherin force transduction activates a kinase cascade via epidermal growth factor receptor and integrins that regulates force-dependent recruitment of VCL to stressed cadherin adhesions.

Summary: The PKD1-mediated classical protein secretory pathway is involved in regulating senescence-associated secretory phenotype factor secretion and oncogene Ras-induced senescence.

Summary: Aplip1 (the Drosophila JIP1) regulates both myonuclear position and muscle stability during early muscle development through different Dynein and Kinesin-regulated mechanisms.