Issues
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Cover image
Cover Image
Cover: A focused ion beam/scanning electron microscopic tomography (FIB/SEM) image of an infected mouse trophoblast showing intracellular Brucella melitensis inside vacuoles by using various coloring schemes. See article by F. Sedzicki et al. (jcs210799).
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RESEARCH HIGHLIGHTS
STICKY WICKET
FIRST PERSON
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
The bone marrow microenvironment in health and disease at a glance
Summary: This article highlights current progress on the role of the bone marrow microenvironment in health and disease.
REVIEWS
Hematopoietic stem cells from induced pluripotent stem cells – considering the role of microRNA as a cell differentiation regulator
Summary: iPSC may be a new source for obtaining hematopoietic stem cells. Here, we discuss the challenges involved in reprogramming, and the role of microRNA in iPSC generation and HSC differentiation.
miRNA targeting and alternative splicing in the stress response – events hosted by membrane-less compartments
Summary: We review how the interplay between miRNA-based gene silencing of mRNAs and alternative splicing of pre-mRNAs are crucial post-transcriptional mechanisms that occur in liquid-like compartments to regulate cellular stress response.
RESEARCH ARTICLES
Axonal endoplasmic reticulum is very narrow
Summary: Using new methods of serial-section electron microscopy, the axonal ER is found to consist of unusually narrow tubules compared with ER tubules in other cells.
Unconventional myosin VIIA promotes melanoma progression
Summary: Myo7a promotes tumor cell migration and metastasis in melanoma cells in a role that is distinct from the role it normally plays in specialized ciliated cells.
Septins are involved at the early stages of macroautophagy in S. cerevisiae
Highlighted Article: Septin proteins, which form cytoskeletal filaments and bind membranes, are required for efficient assembly of functional autophagic structures in budding yeast cells.
Role of membrane-tension gated Ca2+ flux in cell mechanosensation
Highlighted Article: Tissues can sense external mechanical forces. By using a microfluidic compression device, we found that Ca2+ is an important messenger during the early phase of mechanical sensation, and regulates RhoA activity.
The developing Drosophila eye – a new model to study centriole reduction
Highlighted Article: Centriole elimination in the developing Drosophila eye is preceded by the gradual loss of the pericentriolar material.
3D correlative electron microscopy reveals continuity of Brucella-containing vacuoles with the endoplasmic reticulum
Highlighted Article: 3D correlative light and electron microscopy (3D-CLEM) reveals that replicative Brucella-containing vacuoles (rBCVs) are continuous with the ER, indicating that the pathogen replicates inside bona fide host ER.
Functional analysis after rapid degradation of condensins and 3D-EM reveals chromatin volume is uncoupled from chromosome architecture in mitosis
Summary: Rapid condensin depletion reveals that different condensin levels are required for mitotic chromosome architecture and segregation. Condensin is not required for chromatin volume compaction during mitosis.
Characterization of a novel RP2–OSTF1 interaction and its implication for actin remodelling
Summary: OSTF1 is a novel interaction partner for RP2, and this interaction is disrupted by a human pathogenic mutation in RP2. This provides a new link between RP2-associated pathogenesis and actin dynamics.
Inflachromene inhibits autophagy through modulation of Beclin 1 activity
Summary: Inflachromene functions as an autophagy suppressor that inhibits HMGB1 nucleocytoplasmic translocation and enhances Beclin 1 degradation by interacting with RNF216 E3 Ub ligase, and could be a therapeutic factor for autophagy-related diseases.
Maturation of neural stem cells and integration into hippocampal circuits – a functional study in an in situ model of cerebral ischemia
Highlighted Article: Cerebral ischemia in situ impairs functional maturation of neurons derived from embryonic neural stem cells and boosts differentiation of embryonic stem cells into a glial cell type.
FGF2-dependent mesenchyme and laminin-111 are niche factors in salivary gland organoids
Summary: FGF2-dependent primary salivary mesenchyme and laminin-111 provide niche functions in salivary organoids to promote epithelial morphogenesis and expression of the early secretory proacinar markers Kit and AQP5.
Regulation of profibrotic responses by ADAM17 activation in high glucose requires its C-terminus and FAK
Summary: ADAM17 mediates fibrosis in diabetic kidney disease. The ADAM17 C-terminus and its phosphorylation at two sites are crucial for enzyme activation and the profibrotic response to high glucose.
Glycans modify mesenchymal stem cell differentiation to impact on the function of resulting osteoblasts
Summary: Both N- and O-glycan processing modulate MSC differentiation early during osteogenesis to influence mineral formation. Inhibition of N-glycan processing increases mineralization.
Interviews with Biologists @ 100 conference speakers

Explore our interviews with keynote speakers from the Biologists @ 100 conference, hosted to celebrate our publisher’s 100th anniversary, where we discuss climate change and biodiversity with Hans-Otto Pörtner and Jane Francis, health and disease with Charles Swanton and Sadaf Farooqi, and emerging technologies with Manu Prakash and Jennifer Lippincott-Schwartz.
Introducing our new Associate Editors

In this Editorial, JCS Editor-in-Chief Michael Way welcomes five new Associate Editors to the JCS team. These Associate Editors will expand our support for the wider cell biology community and handle articles in immune cell biology, proteostasis, imaging and image analysis, plant cell biology, and stem cell biology and modelling.
The spatial choreography of mRNA biosynthesis

In their Review, André Ventura-Gomes and Maria Carmo-Fonseca detail the latest research progress and technological advancements that are helping to unlock how nuclear organisation underpins control of gene transcription and pre-mRNA splicing.
JCS-FocalPlane Training Grants

Early-career researchers - working in an area covered by JCS - who would like to attend a microscopy training course, please apply. Deadline dates for 2025 applications: 6 June 2025 (decision by week commencing 28 July 2025) and 5 September 2025 (decision by week commencing 20 October 2025).
The emerging roles of the endoplasmic reticulum in mechanosensing and mechanotransduction

In their Review, Jonathan Townson and Cinzia Progida highlight recently emerging evidence for a role of the endoplasmic reticulum in enabling a cell to sense and respond to changes in the extracellular mechanical environment.