Issues

Summary: Studies on endocytosis usually use transformed cells, but the majority of cells in an adult organism have exited the cell cycle. Here, we review endocytosis in dividing, quiescent and terminally differentiated cells.

Summary: TRF2 is recruited to DNA double-strand break damage sites through a two-step mechanism and functions in non-sister chromatid homologous recombination repair.

Summary: The vesicle trafficking regulator α-Snap acts upstream of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway to induce motile cell fate during oogenesis.

Summary: Eukaryotic chemotaxis and pseudopod dynamics are mediated by cGMP and PIP3 signaling pathways, which show characteristic features of excitability and refractoriness.

Summary: A single threonine residue in the G-protein regulatory domain of AGS3 is a determinant factor in the oscillation of AGS3 among different subcellular compartments and protein phase transitions.

Highlighted Article: Exercise and electrical stimulation increase the frequency of elongated mitochondrial constrictions, providing novel structural evidence for mitochondrial dynamics stages in mouse fast-twitch muscle fibers.

Summary: CAP1 is shown to regulate the ADF/cofilin protein family that mediates dynamic actin recycling in mouse oocytes.

Summary: CCDC102B, a protein whose function was previously unknown, is essential for centrosome cohesion and facilitates the filament formation of rootletin.

Highlighted Article: Metal poisoning is one of the bactericidal strategies of macrophages. Here, we describe the dynamics of free Zn²⁺ and the role of Zn²⁺ transporters during phagocytosis in Dictyostelium.

Summary: Autophagy dynamics of microglial cells stimulated with the neuropathogenic protein alpha-synuclein (AS) show that autophagy is activated as a response to control AS-induced lysosomal damage.

Highlighted Article: Tropomyosin 3.5 stabilizes F-actin in eye lens fiber cells and promotes normal tissue biomechanical properties. Tpm3.5 deficiency leads to F-actin network rearrangements and decreased lens stiffness and resilience.

Summary: α-Synuclein and the Rab3A–Munc13-1–Munc18-1 act on the same population of vesicles to enhance exocytosis via different pathways, and α-synuclein activates Ca²⁺ release to enhance priming and fusion.

Summary: Several chaperone genes are differently expressed in ATTR-derived hepatocyte-like cells and SERPINA1 might interfere with TTR aggregation.