CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
Nε-lysine acetylation in the endoplasmic reticulum – a novel cellular mechanism that regulates proteostasis and autophagy
Summary: This Review summarizes recent studies that underscore the importance of the endoplasmic reticulum acetylation process in maintaining protein homeostasis and autophagy within the secretory pathway.
Summary: The Enigma family proteins (PDLIM5/7) link YAP with F-actin stress fibers to participate in integrin-mediated mechanotransduction.
Highlighted Article: A quantitative synthesis of 278 systematically identified studies of mechanically stimulated ATP release, which has been implicated in the pathophysiology of diverse disorders, including inflammation, cystic fibrosis and urinary dysfunction.
Summary: Abnormal induction of the Tf2 retrotransposons upon nitrogen starvation in cells lacking the tsc2+ gene is due to defects in RHEB–mTOR and the glucose/cAMP signaling and induction of autophagy.
The AAA ATPase Afg1 preserves mitochondrial fidelity and cellular health by maintaining mitochondrial matrix proteostasis
Summary: The ATPase Afg1 has evolutionarily conserved roles in both oxidative stress tolerance and mitochondrial protein homeostasis, suggesting its importance in mitochondrial quality control.
The topology of the lymphotoxin β receptor that accumulates upon endolysosomal dysfunction dictates the NF-κB signaling outcome
Summary: Sequestration of LTβR in intraluminal vesicles of endosomes upon depletion of HOPS components or Rab7 precludes NF-κB signaling, whereas LTβR accumulation on the outer endosomal membrane after ESCRT depletion promotes signaling.
Summary: LCP1 forms a ternary complex with αMβ2 integrin and negatively regulates integrin-mediated cell adhesion by maintaining αMβ2 integrin in an inactive conformation.
Summary: Lipid bilayer stress, which can be genetically induced by membrane phospholipid imbalance, leads to the upregulation of autophagy through the ER stress-activated unfolded protein response, promoting cellular homeostasis.
Highlighted Article: Wounding-related changes in the extracellular matrix induce abnormal TGFβ activation and differentiation of lens epithelial cells that could contribute to vision loss after cataract surgery.
GCN5L1 interacts with αTAT1 and RanBP2 to regulate hepatic α-tubulin acetylation and lysosome trafficking
Summary: GCN5L1 interacts with α-tubulin acetyltransferase. In parallel, the nucleoporin RanBP2 facilitates binding of GCN5L1 to α-tubulin to orchestrate microtubule acetylation.
Summary: Here, using pharmacological antagonism or knockdown of P2Y2 receptors, we show that basal lipolysis and adipokine secretion are controlled by autocrine purinergic signalling via P2Y2 receptors in human adipocytes.
Highlighted Article: Necroptotic signaling mediated by RIPK1, RIPK3 and MLKL controls axonal degeneration during neuronal excitotoxic damage.
Summary: Nuclear localization of FIH is governed by two opposing processes: nuclear entry by ‘coupling’ with HIF1α for importin β1-mediated nuclear import, and active export via a leptomycin B-sensitive exportin 1 (CRM1)-dependent pathway.
Highlighted Article: Circular dorsal ruffles in fibroblasts amplify PI3K-dependent signals leading to phosphorylation of Akt in response to EGF or low concentrations of PDGF.