Issues

Summary: The Gwl–Arpp19–Ensa–PP2A-B55 axis act as a molecular switch to turn on and off PP2A-B55 activity. Gwl modulates oncogenic properties of cells and nutrient deprivation influences Gwl activity.

Summary: Apical surfaces of epithelial cells are characterized by the presence of abundant F-actin-based microvilli. We outline recent insights into regulation and maintenance of microvilli and stereocilia.

Highlighted Article: We identify a binding site for kindlin-2 on ILK, and show that disrupting kindlin-2 binding diminishes localization to focal adhesions and impairs cell spreading.

Summary: RPGRIP1L, a key protein of the transition zone that is needed for NPHP4 localization, helps to exclude cytoplasmic proteins from the cilia in Chlamydomonas reinhardtii.

Summary: In Drosophila, localization of the enzyme PIG-B in the nuclear envelope (NE) is important for GPI anchor synthesis, and the NE and the perinuclear ER form a platform for the GPI modification.

Summary: ODF2 maintains centrosome cohesion by restricting premature accumulation of centrosomal β-catenin, which ensure precise chromosome segregation and centrosome disjunction.

Highlighted Article: Systematic analysis of microtubule organization in C. elegans neurons reveals distinct mechanisms that act in dendrites, where distal microtubule nucleation in ciliated neurons stimulates distal dendritic transport.

Summary: Tailored transcription in Plasmodium berghei enables the study of essential mosquito-stage genes, revealing complementary functions of stage-specific adhesins.

Highlighted Article: The Q-SNARE STX19 is S-acylated by Golgi-localised S-acyltransferases, and this lipidation targets the protein to MICAL-L1-positive tubular recycling endosomes and also protects it from proteasomal degradation.