Issues
-
Cover image
Cover Image
Cover: Midgut of an Anopheles mosquito infected with oocysts of Plasmodium berghei on the basal surface. Tubulin is highlighted in blue and DNA is coloured in yellow. Plasmodium oocysts at different stages of development within the mosquito midgut were stained for the circumsporozoite protein (CSP), either with a fluorescent epitope tag (red) or with CSP-specific antibodies (green). As a consequence of developmental variation and an associated differential accessibility to the antibody through the thick oocyst capsule, the CSP expression pattern shows a broad variation from oocyst to oocyst. See article by Klug et al. (jcs210971).
- PDF Icon PDF LinkTable of contents
- PDF Icon PDF LinkIssue info
RESEARCH HIGHLIGHT
FIRST PERSON
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
Greatwall kinase at a glance
Summary: The Gwl–Arpp19–Ensa–PP2A-B55 axis act as a molecular switch to turn on and off PP2A-B55 activity. Gwl modulates oncogenic properties of cells and nutrient deprivation influences Gwl activity.
REVIEW
Regulation of actin-based apical structures on epithelial cells
Summary: Apical surfaces of epithelial cells are characterized by the presence of abundant F-actin-based microvilli. We outline recent insights into regulation and maintenance of microvilli and stereocilia.
RESEARCH ARTICLES
Kindlin-2 interacts with a highly conserved surface of ILK to regulate focal adhesion localization and cell spreading
Highlighted Article: We identify a binding site for kindlin-2 on ILK, and show that disrupting kindlin-2 binding diminishes localization to focal adhesions and impairs cell spreading.
RPGRIP1L helps to establish the ciliary gate for entry of proteins
Summary: RPGRIP1L, a key protein of the transition zone that is needed for NPHP4 localization, helps to exclude cytoplasmic proteins from the cilia in Chlamydomonas reinhardtii.
Nuclear envelope localization of PIG-B is essential for GPI-anchor synthesis in Drosophila
Summary: In Drosophila, localization of the enzyme PIG-B in the nuclear envelope (NE) is important for GPI anchor synthesis, and the NE and the perinuclear ER form a platform for the GPI modification.
ODF2 maintains centrosome cohesion by restricting β-catenin accumulation
Summary: ODF2 maintains centrosome cohesion by restricting premature accumulation of centrosomal β-catenin, which ensure precise chromosome segregation and centrosome disjunction.
Local microtubule organization promotes cargo transport in C. elegans dendrites
Highlighted Article: Systematic analysis of microtubule organization in C. elegans neurons reveals distinct mechanisms that act in dendrites, where distal microtubule nucleation in ciliated neurons stimulates distal dendritic transport.
A synthetic promoter for multi-stage expression to probe complementary functions of Plasmodium adhesins
Summary: Tailored transcription in Plasmodium berghei enables the study of essential mosquito-stage genes, revealing complementary functions of stage-specific adhesins.
S-acylation regulates the trafficking and stability of the unconventional Q-SNARE STX19
Highlighted Article: The Q-SNARE STX19 is S-acylated by Golgi-localised S-acyltransferases, and this lipidation targets the protein to MICAL-L1-positive tubular recycling endosomes and also protects it from proteasomal degradation.
Interviews with Biologists @ 100 conference speakers

Explore our interviews with keynote speakers from the Biologists @ 100 conference, hosted to celebrate our publisher’s 100th anniversary, where we discuss climate change and biodiversity with Hans-Otto Pörtner and Jane Francis, health and disease with Charles Swanton and Sadaf Farooqi, and emerging technologies with Manu Prakash and Jennifer Lippincott-Schwartz.
Introducing our new Associate Editors

In this Editorial, JCS Editor-in-Chief Michael Way welcomes five new Associate Editors to the JCS team. These Associate Editors will expand our support for the wider cell biology community and handle articles in immune cell biology, proteostasis, imaging and image analysis, plant cell biology, and stem cell biology and modelling.
The spatial choreography of mRNA biosynthesis

In their Review, André Ventura-Gomes and Maria Carmo-Fonseca detail the latest research progress and technological advancements that are helping to unlock how nuclear organisation underpins control of gene transcription and pre-mRNA splicing.
JCS-FocalPlane Training Grants

Early-career researchers - working in an area covered by JCS - who would like to attend a microscopy training course, please apply. Deadline dates for 2025 applications: 6 June 2025 (decision by week commencing 28 July 2025) and 5 September 2025 (decision by week commencing 20 October 2025).
The emerging roles of the endoplasmic reticulum in mechanosensing and mechanotransduction

In their Review, Jonathan Townson and Cinzia Progida highlight recently emerging evidence for a role of the endoplasmic reticulum in enabling a cell to sense and respond to changes in the extracellular mechanical environment.