Issues
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Cover image
Cover Image
Cover: Midgut of an Anopheles mosquito infected with oocysts of Plasmodium berghei on the basal surface. Tubulin is highlighted in blue and DNA is coloured in yellow. Plasmodium oocysts at different stages of development within the mosquito midgut were stained for the circumsporozoite protein (CSP), either with a fluorescent epitope tag (red) or with CSP-specific antibodies (green). As a consequence of developmental variation and an associated differential accessibility to the antibody through the thick oocyst capsule, the CSP expression pattern shows a broad variation from oocyst to oocyst. See article by Klug et al. (jcs210971).
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RESEARCH HIGHLIGHT
FIRST PERSON
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
Greatwall kinase at a glance
Summary: The Gwl–Arpp19–Ensa–PP2A-B55 axis act as a molecular switch to turn on and off PP2A-B55 activity. Gwl modulates oncogenic properties of cells and nutrient deprivation influences Gwl activity.
REVIEW
Regulation of actin-based apical structures on epithelial cells
Summary: Apical surfaces of epithelial cells are characterized by the presence of abundant F-actin-based microvilli. We outline recent insights into regulation and maintenance of microvilli and stereocilia.
RESEARCH ARTICLES
Kindlin-2 interacts with a highly conserved surface of ILK to regulate focal adhesion localization and cell spreading
Highlighted Article: We identify a binding site for kindlin-2 on ILK, and show that disrupting kindlin-2 binding diminishes localization to focal adhesions and impairs cell spreading.
RPGRIP1L helps to establish the ciliary gate for entry of proteins
Summary: RPGRIP1L, a key protein of the transition zone that is needed for NPHP4 localization, helps to exclude cytoplasmic proteins from the cilia in Chlamydomonas reinhardtii.
Nuclear envelope localization of PIG-B is essential for GPI-anchor synthesis in Drosophila
Summary: In Drosophila, localization of the enzyme PIG-B in the nuclear envelope (NE) is important for GPI anchor synthesis, and the NE and the perinuclear ER form a platform for the GPI modification.
ODF2 maintains centrosome cohesion by restricting β-catenin accumulation
Summary: ODF2 maintains centrosome cohesion by restricting premature accumulation of centrosomal β-catenin, which ensure precise chromosome segregation and centrosome disjunction.
Local microtubule organization promotes cargo transport in C. elegans dendrites
Highlighted Article: Systematic analysis of microtubule organization in C. elegans neurons reveals distinct mechanisms that act in dendrites, where distal microtubule nucleation in ciliated neurons stimulates distal dendritic transport.
A synthetic promoter for multi-stage expression to probe complementary functions of Plasmodium adhesins
Summary: Tailored transcription in Plasmodium berghei enables the study of essential mosquito-stage genes, revealing complementary functions of stage-specific adhesins.
S-acylation regulates the trafficking and stability of the unconventional Q-SNARE STX19
Highlighted Article: The Q-SNARE STX19 is S-acylated by Golgi-localised S-acyltransferases, and this lipidation targets the protein to MICAL-L1-positive tubular recycling endosomes and also protects it from proteasomal degradation.
Imaging Cell Architecture and Dynamics

We are now welcoming submissions for our upcoming Special Issue: Imaging Cell Architecture and Dynamics. This issue will be coordinated by two Guest Editors: Lucy Collinson (The Francis Crick Institute, UK) and Guillaume Jacquemet (University of Turku, Finland). Submission deadline: 1 March 2024.
2024 Journal Meeting 'Diversity and Evolution in Cell Biology'

Registration is open for our 2024 Journal Meeting Diversity and Evolution in Cell Biology, which aims to bring together evolutionary biologists and cell biologists investigating diverse aspects of cellular physiology. Early-bird deadline is 19 January 2024.
Become a FocalPlane correspondent

FocalPlane, our community site for microscopists, is looking to appoint three scientists as correspondents who will play a key role in developing and writing content over the coming year. Interested? Find out how to become a FocalPlane correspondent here.
Sustainable Conferencing Initiative

Through our Sustainable Conferencing Grants, we promote the use of new technology and greener modes of travel. Our blog posts showcase examples of sustainability in action and share experience about how new technologies and conference formats work in practice.
Reasons to submit to Journal of Cell Science

There are many benefits to publishing in Journal of Cell Science - read more about why you should choose JCS or visit our submission page now.