CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
Summary: Apical surfaces of epithelial cells are characterized by the presence of abundant F-actin-based microvilli. We outline recent insights into regulation and maintenance of microvilli and stereocilia.
Kindlin-2 interacts with a highly conserved surface of ILK to regulate focal adhesion localization and cell spreading
Highlighted Article: We identify a binding site for kindlin-2 on ILK, and show that disrupting kindlin-2 binding diminishes localization to focal adhesions and impairs cell spreading.
Summary: RPGRIP1L, a key protein of the transition zone that is needed for NPHP4 localization, helps to exclude cytoplasmic proteins from the cilia in Chlamydomonas reinhardtii.
Summary: In Drosophila, localization of the enzyme PIG-B in the nuclear envelope (NE) is important for GPI anchor synthesis, and the NE and the perinuclear ER form a platform for the GPI modification.
Summary: ODF2 maintains centrosome cohesion by restricting premature accumulation of centrosomal β-catenin, which ensure precise chromosome segregation and centrosome disjunction.
Highlighted Article: Systematic analysis of microtubule organization in C. elegans neurons reveals distinct mechanisms that act in dendrites, where distal microtubule nucleation in ciliated neurons stimulates distal dendritic transport.
A synthetic promoter for multi-stage expression to probe complementary functions of Plasmodium adhesins
Summary: Tailored transcription in Plasmodium berghei enables the study of essential mosquito-stage genes, revealing complementary functions of stage-specific adhesins.
Highlighted Article: The Q-SNARE STX19 is S-acylated by Golgi-localised S-acyltransferases, and this lipidation targets the protein to MICAL-L1-positive tubular recycling endosomes and also protects it from proteasomal degradation.