CELL SCIENTISTS TO WATCH
Summary: A review of recent findings that demonstrate autophagy-dependent cell death in various contexts and begin to elucidate molecular mechanisms that render autophagy a lethal process.
Summary: This Review discusses recent discoveries regarding the unusual segregation system of the single-unit mitochondrial genome of T. brucei.
Summary: Nuclear functions of mammalian EGF receptors contribute to cancer. Here, we show that such functions are not conserved in the invertebrate Drosophila.
The LTB4–BLT1 axis regulates the polarized trafficking of chemoattractant GPCRs during neutrophil chemotaxis
Summary: The leukotriene B4–BLT1 axis regulates the polarized trafficking of the chemoattractant receptors FPR1 and C5aR1 from the trailing edge of polarized neutrophils, to drive persistent chemotaxis.
Summary: LRRC45 at distal appendages is required for early steps of axoneme extension by promoting transition zone establishment, Rab8a recruitment and satellite organisation.
Nutritional cell cycle reprogramming reveals that inhibition of Cdk1 is required for proper MBF-dependent transcription
Summary: In nitrogen-poor medium, inhibition of Cdk1 becomes essential for generating a proper wave of MBF-dependent transcription at G1/S, which prevents DNA replication stress.
Summary: Rab4A controls cargo segregation by forming a complex with rabenosyn-5, KIF3 and AP-3 on sorting endosomes to divert the cargo toward melanosomes.
LIF-dependent survival of embryonic stem cells is regulated by a novel palmitoylated Gab1 signalling protein
Highlighted Article: Embryonic stem cells rely upon expression of a novel lipid-modified Gab1 adaptor protein to promote survival under nutrient-poor conditions.
Highlighted Article: Nuclei are highly branched throughout the heterogeneous population of healthy epidermal cells in the Xenopus tail fin periphery, and disruption of nuclear branching results in improper fin morphology.
Highlighted Article: Drosophila scarlet mutants show progressive loss of dopaminergic neurons, along with locomotor impairments, and Scarlet has a neuroprotective role in a Parkinson's disease model.