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RESEARCH HIGHLIGHT

FIRST PERSON

MEETING REPORT

CELL SCIENCE AT A GLANCE

Summary: The endoplasmic reticulum is the largest organelle of the cell and it fulfils a plethora of biological functions. The constant ER membrane turnover is therefore needed and is mediated by ER-phagy.

REVIEW

Summary: Clathrin-mediated endocytosis is an essential cellular mechanism by which all eukaryotic cells regulate their plasma membrane composition. Here, we discuss how the nanoscale organization of endocytic proteins reshapes the plasma membrane.

SHORT REPORT

Summary: T cell activation promotes assembly of the nucleotide biosynthesis enzyme inosine 5'-monophosphate dehydrogenase (IMPDH) into macromolecular structures resembling filaments.

RESEARCH ARTICLES

Summary: The endosomal recruitment of UBR4 is essential for the biogenesis of early endosomes and endosome-related processes such as the trafficking and proteolysis of endocytosed cargos.

Summary: Myosin XIX (Myo19) and microtubule-based motors compete for binding to the outer mitochondrial membrane proteins Miro1/2.

Summary: A potential scaffolding function for SNX21 paves the way for a more-detailed mechanistic analysis of the role(s) of this protein in endosomal biology.

Summary: The small GTPase Rab6 is shown to promote autophagic homeostasis by balancing production and degradation of autophagosomes through effects on cathepsin and insulin receptor trafficking.

Summary: The peroxisomal import model in budding yeast gets more intricate. PTS1-containing Fox2p and Cta1p enter peroxisomes partly via an alternative, PTS1-independent route driven by the dual-function receptor Pex5p.

Highlighted Article: New evidence highlights an association between nuclear expression of the TGFβ-driven transcription factors, SMAD2/3 and the proliferative state of granulosa cells of follicles in the ovarian reserve.

Summary: The I-BAR domain-containing protein Ivy1 colocalizes with the EGO complex components Gtr1 and Gtr2 and regulates their activation.

Highlighted Article: Upregulation of flotillins promotes MT1-MMP trafficking through endolysosomes, which allows its efficient recycling from the plasma membrane to degradation sites.

Highlighted Article: All roads lead to cilia – how the essential flagellar enrichment of Arl13 is achieved in trypanosome cells using a fundamentally different strategy compared with that of animal cells.

Summary: We demonstrate that cancer cells can compensate for Hsp70 inhibition by inducing autophagy, emphasizing the role of autophagy/chaperone-based therapies.

Summary: Using novel approaches we find no major variations in global translation rates through the cell cycle. We also present insights into the role of phosphorylation of eukaryotic initiation factor-2α (eIF2α).

Highlighted Article:Dictyostelium discoideum LmpA and LmpB are functional homologues of LIMP-2 and CD36, respectively, and play roles in phagosome maturation and host defence against a bacterial pathogen.

Summary: TBC1D5 is identified in an siRNA screen as the GAP for Rab7b, and controls the distribution and membrane kinetics of this small GTPase, mediating endosome to trans-Golgi transport.

Summary: This paper describes new players in the regulation of mitotic spindle dynamics during mitosis in the model organism Saccharomyces cerevisiae.

Summary: Organization of heterochromatin and gene expression is coordinated by SCML2 through the regulation of Polycomb complexes in the male germline of mice.

Highlighted Article: The transcription factor Grainy head is involved in tissue repair, through ensuring the formation of a proper contractile actomyosin cable and the regulation of adherens junction dynamics.

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