Issues
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Cover image
Cover Image
Cover: A confocal microscopy image of mouse embryonic fibroblasts immunostained for filamentous actin (green) , β-tubulin (red) and nuclear DNA (blue). See article by Kim et al. (jcs217646).
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RESEARCH HIGHLIGHT
FIRST PERSON
MEETING REPORT
CELL SCIENCE AT A GLANCE
ER-phagy at a glance
Summary: The endoplasmic reticulum is the largest organelle of the cell and it fulfils a plethora of biological functions. The constant ER membrane turnover is therefore needed and is mediated by ER-phagy.
REVIEW
Membrane remodeling in clathrin-mediated endocytosis
Summary: Clathrin-mediated endocytosis is an essential cellular mechanism by which all eukaryotic cells regulate their plasma membrane composition. Here, we discuss how the nanoscale organization of endocytic proteins reshapes the plasma membrane.
SHORT REPORT
T cell activation triggers reversible inosine-5′-monophosphate dehydrogenase assembly
Summary: T cell activation promotes assembly of the nucleotide biosynthesis enzyme inosine 5'-monophosphate dehydrogenase (IMPDH) into macromolecular structures resembling filaments.
RESEARCH ARTICLES
The N-recognin UBR4 of the N-end rule pathway is targeted to and required for the biogenesis of the early endosome
Summary: The endosomal recruitment of UBR4 is essential for the biogenesis of early endosomes and endosome-related processes such as the trafficking and proteolysis of endocytosed cargos.
Identification of Miro1 and Miro2 as mitochondrial receptors for myosin XIX
Summary: Myosin XIX (Myo19) and microtubule-based motors compete for binding to the outer mitochondrial membrane proteins Miro1/2.
Sorting nexin-21 is a scaffold for the endosomal recruitment of huntingtin
Summary: A potential scaffolding function for SNX21 paves the way for a more-detailed mechanistic analysis of the role(s) of this protein in endosomal biology.
Rab6 promotes insulin receptor and cathepsin trafficking to regulate autophagy induction and activity in Drosophila
Summary: The small GTPase Rab6 is shown to promote autophagic homeostasis by balancing production and degradation of autophagosomes through effects on cathepsin and insulin receptor trafficking.
The budding yeast Pex5p receptor directs Fox2p and Cta1p into peroxisomes via its N-terminal region near the FxxxW domain
Summary: The peroxisomal import model in budding yeast gets more intricate. PTS1-containing Fox2p and Cta1p enter peroxisomes partly via an alternative, PTS1-independent route driven by the dual-function receptor Pex5p.
Nuclear exclusion of SMAD2/3 in granulosa cells is associated with primordial follicle activation in the mouse ovary
Highlighted Article: New evidence highlights an association between nuclear expression of the TGFβ-driven transcription factors, SMAD2/3 and the proliferative state of granulosa cells of follicles in the ovarian reserve.
Ivy1 is a negative regulator of Gtr-dependent TORC1 activation
Summary: The I-BAR domain-containing protein Ivy1 colocalizes with the EGO complex components Gtr1 and Gtr2 and regulates their activation.
MT1-MMP targeting to endolysosomes is mediated by upregulation of flotillins
Highlighted Article: Upregulation of flotillins promotes MT1-MMP trafficking through endolysosomes, which allows its efficient recycling from the plasma membrane to degradation sites.
The unusual flagellar-targeting mechanism and functions of the trypanosome ortholog of the ciliary GTPase Arl13b
Highlighted Article: All roads lead to cilia – how the essential flagellar enrichment of Arl13 is achieved in trypanosome cells using a fundamentally different strategy compared with that of animal cells.
Compensatory increases of select proteostasis networks after Hsp70 inhibition in cancer cells
Summary: We demonstrate that cancer cells can compensate for Hsp70 inhibition by inducing autophagy, emphasizing the role of autophagy/chaperone-based therapies.
Regulation of global translation during the cell cycle
Summary: Using novel approaches we find no major variations in global translation rates through the cell cycle. We also present insights into the role of phosphorylation of eukaryotic initiation factor-2α (eIF2α).
Functions of the Dictyostelium LIMP-2 and CD36 homologues in bacteria uptake, phagolysosome biogenesis and host cell defence
Highlighted Article: Dictyostelium discoideum LmpA and LmpB are functional homologues of LIMP-2 and CD36, respectively, and play roles in phagosome maturation and host defence against a bacterial pathogen.
TBC1D5 controls the GTPase cycle of Rab7b
Summary: TBC1D5 is identified in an siRNA screen as the GAP for Rab7b, and controls the distribution and membrane kinetics of this small GTPase, mediating endosome to trans-Golgi transport.
Swe1 and Mih1 regulate mitotic spindle dynamics in budding yeast via Bik1
Summary: This paper describes new players in the regulation of mitotic spindle dynamics during mitosis in the model organism Saccharomyces cerevisiae.
SCML2 promotes heterochromatin organization in late spermatogenesis
Summary: Organization of heterochromatin and gene expression is coordinated by SCML2 through the regulation of Polycomb complexes in the male germline of mice.
Novel role for Grainy head in the regulation of cytoskeletal and junctional dynamics during epithelial repair
Highlighted Article: The transcription factor Grainy head is involved in tissue repair, through ensuring the formation of a proper contractile actomyosin cable and the regulation of adherens junction dynamics.
CORRECTION
PREPRINT HIGHLIGHTS
Special Issue – Cell Biology of Mitochondria

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Mitochondria–membranous organelle contacts at a glance

Antigoni Diokmetzidou and Luca Scorrano provide an overview of contacts between mitochondria and other membranous organelles, describing the interorganelle tethers involved and the factors that regulate the composition and functions of such contacts.
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