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Summary: In this Cell Science at a Glance article we summarize the current knowledge on the escape of viruses from the endosomal compartment and the cellular detection mechanisms that counteract it.


Summary: We summarize the molecular machinery shared between exosome biogenesis and the autophagy pathway, and describe the coordination between these two processes in multiple contexts, including neurodegeneration and cancer.


Summary: Long-term severe ethanol stress induces the formation of a unique high-ordered structure (multiple small cortical rings) of septin, accompanied by a depolarized actin cytoskeleton in yeast.


Summary: Integrin-dependent and integrin-independent mechanisms of glioma cell invasion in 3D brain-like environments indicate remarkable adhesion plasticity and escape routes from targeted intervention.

Highlighted Article: Cerebral cavernous malformation proteins control non-redundant ROCK1 and ROCK2 functions to preserve endothelial integrity. This study identified ROCK1 as a potential therapeutic target.

Summary: Rac1 activation promotes both the initial formation of AChR clusters as well as the dispersal of pre-existing clusters, whereas Rac1 inhibition is required to stabilize clusters.

Highlighted Article: Two different disease-associated FGFR2 mutations that lead to poor outcome in endometrial cancer patients, both affect collective cell polarity and invasion.

Summary: These data identify a new PIM-CHK1-PLK1 phosphorylation cascade that regulates different mitotic steps independently of the CHK1 DNA damage response function.

Summary: Connexin 43 in gap junctions becomes K63-polyubiquitylated on lysines 264 and 303, which is required for gap junction endocytosis.

Summary: The receptor PTPα is an essential component of integrin and dystroglycan receptor complexes that transduce extrinsic laminin-2 signals into specific intracellular events to promote OL differentiation.

Summary: Adenosine and its metabolism by adenosine kinase regulate autophagy independent of nutrient availability and the canonical AMPK–mTORC1 pathway. In β-cells, adenosine regulates insulin secretion, in part, through modulation of autophagy.

Highlighted Article: The enzyme PI4KIIIα works with two other proteins to produce PI4P, which feeds into the PIP2 pool at the plasma membrane. This is required for PLC signaling during Drosophila phototransduction.

Summary: GRWD1 is a tumor-promoting factor. We comprehensively identified human GRWD1-interacting proteins, and performed functional analysis of GRWD1 during proteolytic regulation of RPL23, a tumor suppressor protein.

Highlighted Article: Myosin binding protein-C functionally interacts with the cardiac Ca2+ release channel (RyR2), suggesting a novel retrograde regulation mechanism for muscle excitation–contraction coupling.

Summary: The Cul4–DDB1–Gβ E3 ubiquitin ligase complex regulates Smoothened trafficking and Hedgehog signaling in Drosophila.


Summary: Development of a simple fluorescence imaging chamber allowing observation of intracellular protein dynamics and molecular events in living cells at pressure up to 200 bar.

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