CELL SCIENCE AT A GLANCE
Summary: This Review discusses eukaryotic chromosome segregation in the light of biological diversity, covering a number of experimental approaches used in comparative biology studies.
Summary: β4 integrin associates with vimentin at the periphery of migrating epithelial cells, and such β4 integrin–vimentin complexes support signaling through Rac1, leading to directed cell migration.
Summary: A positive feedforward control loop mediated by the inhibition of nuclear phosphatase activity endows striatal neuron with a supersensitive and all-or-nothing responsiveness to transient dopamine signals.
Distinct metabolic states govern skeletal muscle stem cell fates during prenatal and postnatal myogenesis
Summary: Distinct energy metabolism pathways act during mouse skeletal muscle stem cell commitment and differentiation in different physiological states.
PAI1 blocks NMDA receptor-mediated effects of tissue-type plasminogen activator on cell signaling and physiology
Summary: PAI1 inhibits the effects of tissue-type plasminogen activator on cell signaling and physiology mediated by the NMDA receptor. The mechanism of PAI1 activity involves targeting of tPA to the endocytic receptor LRP1.
p38δ MAPK regulates aggresome biogenesis by phosphorylating SQSTM1 in response to proteasomal stress
Highlighted Article: Proteasomal stress promotes the recruitment of small protein aggregates to perinuclear aggresomes through the activation of p38γ and p38δ.
Summary: In high-glucose conditions, nociceptive neurons are sensitised through the actions of HMGB1 acting though RAGE and PKC. This sensitisation is blocked by a VEGF-A splice variant.
AMP-activated protein kinase promotes epithelial-mesenchymal transition in cancer cells through Twist1 upregulation
Highlighted Article: Pharmacological and physiological activation of AMPK promotes epithelial-mesenchymal transition in cancer cells through Twist1 upregulation and its increased nuclear localization.
Histone arginine methylation by Prmt5 is required for lung branching morphogenesis through repression of BMP signaling
Summary: Prmt5 methylates H4R3 of the Bmp4 chromatin symmetrically, which in turn suppresses canonical BMP signaling to regulate lung branching morphogenesis.
Local and global Cdc42 guanine nucleotide exchange factors for fission yeast cell polarity are coordinated by microtubules and the Tea1–Tea4–Pom1 axis
Highlighted Article: Cell polarity in fission yeast is regulated by two different Cdc42 guanine nucleotide exchange factors, coordinated by the microtubule-dependent landmark system.
Summary: Annexin secretion involves protein translocation across membrane that is facilitated by transbilayer lipid movement.
Golgi localization of oxysterol binding protein-related protein 4L (ORP4L) is regulated by ligand binding
Summary: ORP4L localization to contact sites between the Golgi and endoplasmic reticulum involves interaction with OSBP and PI(4)P, and is required for organelle structure and PI(4)P content.
APC/CFzr regulates cardiac and myoblast cell numbers, and plays a crucial role during myoblast fusion
Highlighted Article: The anaphase-promoting complex has a novel and unexpected role during myoblast fusion.