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Summary: This Review discusses unconventional protein secretion from a pathophysiological point of view, giving important insights regarding future drugs to treat a wide spectrum of human diseases and disorders.

Summary: This Review provides an overview of the known pathways that are regulated by integrin–ECM interaction in developing neurons and in adult brain. Mechanisms that regulate integrin activity in neurons are also described.


Summary: Factors that affect cellular force propagation through cells lead to changes in chromatin dynamics. The SINK technique can be used to characterize mechanical aspects of cell monolayers.


Highlighted Article: An Fe-S cluster binding in a cysteine-rich domain of the chromokinesin KIF4A is an important determinant of its correct localization to its functional sites during mitosis.

Highlighted Article: Myosin-1c is a regulator of intercellular tension that can promote tension generation from the extracellular domain of E-cadherin, propagating actomyosin-generated force to intercellular junctions.

Summary: The cell cycle protein cyclin D1, independently of its role in cell cycle regulation, acts as a controller of oxidative balance in cancer cells. This function is required for cancer cell survival.

Summary: Sphingolipids restrict access to extracellular nutrients by inhibiting the endosomal recycling of cell surface amino acid and glucose transporters downstream of ARF6 inactivation.

Summary: The α-isoform of OGG1 is imported into mitochondria, where its glycosylase activity is essential for mitochondrial maintenance in human cells exposed to oxidative stress.

Summary: Polη, a specialized DNA polymerase, protects replication forks from Myc-induced impediment and promotes the growth of Myc-activated cells. This finding offers new insight into tumorigenesis.

Summary: H3K27me2/3 modulates FANCD2 on chromatin in NHEJ, supporting a new mechanism for hypo-H3K27me2/3 in cancers resulting from genome instability by inefficient DSB repair.

Summary: Endothelial cells react to acute changes in hydrostatic pressure through Ca2+-mediated myosin activation and subsequent stiffening, without losing barrier integrity.

Highlighted Article: Enhancement of retromer complex function through inhibition of TBC1D5, a Rab GTPase-activating protein for Rab7a, leads to a gain of function for retromer-mediated endosomal sorting.

Summary: Rapid wound closure of the vertebrate embryonic epidermis depends on interplay between the cytoskeletal components actin, microtubules and septin.

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