Issues
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Cover image
Cover Image
Cover: Vaccinia virus infection disrupts the integrity of an epithelial cell monolayer. Infected cells (red) have lost their cell–cell contacts and are migrating. The actin and microtubule cytoskeletons are shown in blue and green, respectively. Image: Michael Way, Cellular Signalling and Cytoskeletal Function Laboratory, The Francis Crick Institute, London, UK.
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RESEARCH HIGHLIGHTS
FIRST PERSON
CELL SCIENTISTS TO WATCH
MEETING REPORT
REVIEWS
Unconventional protein secretion – new insights into the pathogenesis and therapeutic targets of human diseases
Summary: This Review discusses unconventional protein secretion from a pathophysiological point of view, giving important insights regarding future drugs to treat a wide spectrum of human diseases and disorders.
Integrin activity in neuronal connectivity
Summary: This Review provides an overview of the known pathways that are regulated by integrin–ECM interaction in developing neurons and in adult brain. Mechanisms that regulate integrin activity in neurons are also described.
SHORT REPORT
Determining mechanical features of modulated epithelial monolayers using subnuclear particle tracking
Summary: Factors that affect cellular force propagation through cells lead to changes in chromatin dynamics. The SINK technique can be used to characterize mechanical aspects of cell monolayers.
RESEARCH ARTICLES
Fe-S cluster coordination of the chromokinesin KIF4A alters its subcellular localization during mitosis
Highlighted Article: An Fe-S cluster binding in a cysteine-rich domain of the chromokinesin KIF4A is an important determinant of its correct localization to its functional sites during mitosis.
Myosin-1c promotes E-cadherin tension and force-dependent recruitment of α-actinin to the epithelial cell junction
Highlighted Article: Myosin-1c is a regulator of intercellular tension that can promote tension generation from the extracellular domain of E-cadherin, propagating actomyosin-generated force to intercellular junctions.
Cyclin D1 depletion interferes with oxidative balance and promotes cancer cell senescence
Summary: The cell cycle protein cyclin D1, independently of its role in cell cycle regulation, acts as a controller of oxidative balance in cancer cells. This function is required for cancer cell survival.
Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6
Summary: Sphingolipids restrict access to extracellular nutrients by inhibiting the endosomal recycling of cell surface amino acid and glucose transporters downstream of ARF6 inactivation.
Mitochondrial maintenance under oxidative stress depends on mitochondrially localised α-OGG1
Summary: The α-isoform of OGG1 is imported into mitochondria, where its glycosylase activity is essential for mitochondrial maintenance in human cells exposed to oxidative stress.
Polη, a Y-family translesion synthesis polymerase, promotes cellular tolerance of Myc-induced replication stress
Summary: Polη, a specialized DNA polymerase, protects replication forks from Myc-induced impediment and promotes the growth of Myc-activated cells. This finding offers new insight into tumorigenesis.
Histone H3K27 methylation modulates the dynamics of FANCD2 on chromatin to facilitate NHEJ and genome stability
Summary: H3K27me2/3 modulates FANCD2 on chromatin in NHEJ, supporting a new mechanism for hypo-H3K27me2/3 in cancers resulting from genome instability by inefficient DSB repair.
A two-phase response of endothelial cells to hydrostatic pressure
Summary: Endothelial cells react to acute changes in hydrostatic pressure through Ca2+-mediated myosin activation and subsequent stiffening, without losing barrier integrity.
Inhibition of TBC1D5 activates Rab7a and can enhance the function of the retromer cargo-selective complex
Highlighted Article: Enhancement of retromer complex function through inhibition of TBC1D5, a Rab GTPase-activating protein for Rab7a, leads to a gain of function for retromer-mediated endosomal sorting.
Septin-dependent remodeling of cortical microtubule drives cell reshaping during epithelial wound healing
Summary: Rapid wound closure of the vertebrate embryonic epidermis depends on interplay between the cytoskeletal components actin, microtubules and septin.
Call for papers - Cilia and Flagella: from Basic Biology to Disease
We are welcoming submissions for our upcoming special issue: Cilia and Flagella: from Basic Biology to Disease. This issue will be coordinated by two Guest Editors: Pleasantine Mill (University of Edinburgh) and Lotte Pedersen (University of Copenhagen). Extended submission deadline: 31 March 2025.
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about Journal of Cell Science’s journey and explore the history of each of our sister journals: Development, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.
Introducing our new Associate Editors
In this Editorial, JCS Editor-in-Chief Michael Way welcomes five new Associate Editors to the JCS team. These Associate Editors will expand our support for the wider cell biology community and handle articles in immune cell biology, proteostasis, imaging and image analysis, plant cell biology, and stem cell biology and modelling.
Diversity of microtubule arrays in animal cells at a glance
In this Cell Science at a Glance article, Emma van Grinsven and Anna Akhmanova provide an overview of the diverse microtubule arrays present in differentiated animal cells and discuss how these arrays form and function.
JCS-FocalPlane Training Grants
Early-career researchers - working in an area covered by JCS - who would like to attend a microscopy training course, please apply. Deadline dates for 2025 applications: 7 March 2025 (decision by week commencing 21 April 2025) and 6 June 2025 (decision by week commencing 28 July 2025).
