CELL SCIENTISTS TO WATCH
Unconventional protein secretion – new insights into the pathogenesis and therapeutic targets of human diseases
Summary: This Review discusses unconventional protein secretion from a pathophysiological point of view, giving important insights regarding future drugs to treat a wide spectrum of human diseases and disorders.
Determining mechanical features of modulated epithelial monolayers using subnuclear particle tracking
Summary: Factors that affect cellular force propagation through cells lead to changes in chromatin dynamics. The SINK technique can be used to characterize mechanical aspects of cell monolayers.
Fe-S cluster coordination of the chromokinesin KIF4A alters its subcellular localization during mitosis
Highlighted Article: An Fe-S cluster binding in a cysteine-rich domain of the chromokinesin KIF4A is an important determinant of its correct localization to its functional sites during mitosis.
Myosin-1c promotes E-cadherin tension and force-dependent recruitment of α-actinin to the epithelial cell junction
Highlighted Article: Myosin-1c is a regulator of intercellular tension that can promote tension generation from the extracellular domain of E-cadherin, propagating actomyosin-generated force to intercellular junctions.
Summary: The cell cycle protein cyclin D1, independently of its role in cell cycle regulation, acts as a controller of oxidative balance in cancer cells. This function is required for cancer cell survival.
Summary: Sphingolipids restrict access to extracellular nutrients by inhibiting the endosomal recycling of cell surface amino acid and glucose transporters downstream of ARF6 inactivation.
Summary: The α-isoform of OGG1 is imported into mitochondria, where its glycosylase activity is essential for mitochondrial maintenance in human cells exposed to oxidative stress.
Polη, a Y-family translesion synthesis polymerase, promotes cellular tolerance of Myc-induced replication stress
Summary: Polη, a specialized DNA polymerase, protects replication forks from Myc-induced impediment and promotes the growth of Myc-activated cells. This finding offers new insight into tumorigenesis.
Histone H3K27 methylation modulates the dynamics of FANCD2 on chromatin to facilitate NHEJ and genome stability
Summary: H3K27me2/3 modulates FANCD2 on chromatin in NHEJ, supporting a new mechanism for hypo-H3K27me2/3 in cancers resulting from genome instability by inefficient DSB repair.
Summary: Endothelial cells react to acute changes in hydrostatic pressure through Ca2+-mediated myosin activation and subsequent stiffening, without losing barrier integrity.
Inhibition of TBC1D5 activates Rab7a and can enhance the function of the retromer cargo-selective complex
Highlighted Article: Enhancement of retromer complex function through inhibition of TBC1D5, a Rab GTPase-activating protein for Rab7a, leads to a gain of function for retromer-mediated endosomal sorting.
Septin-dependent remodeling of cortical microtubule drives cell reshaping during epithelial wound healing
Summary: Rapid wound closure of the vertebrate embryonic epidermis depends on interplay between the cytoskeletal components actin, microtubules and septin.