Skip to Main Content

Advertisement

Skip Nav Destination

Issues

RESEARCH HIGHLIGHTS

FIRST PERSON

CELL SCIENCE AT A GLANCE

Summary: This Cell Science at a Glance article summarizes how plasmodesmata are dynamic and multifaceted nanochannels that bridge neighboring plant cells.

REVIEW

Summary: This Review highlights the common signalling pathways in macrophage and osteoclast multinucleation. This basic cell phenomenon which underlies various complex diseases is poorly understood.

SHORT REPORT

Summary: Loss of CCAR-1 function during C. elegans embryogenesis results in dysregulated alternative splicing of unc-52 (the homolog of mammalian perlecan) and hemidesmosome disruption.

Summary: Rec8-mediated cohesion is reconstituted in a somatic cell line and shown to chiefly depend on co-expression of Stag3. Rec8–Stag3-containing cohesin is antagonised by Wapl and protected by sororin.

Summary: In addition to its canonical pathway, the photoreceptor melanopsin (Opn4) signals through G proteins βγ and αi and controls several major signaling pathways, which may explain its multi-functionality.

RESEARCH ARTICLES

Highlighted Article: Daughter-neighbour cell disentanglement during multicellular cytokinesis is driven by the coordinated basal descent of the midbody and de novo assembly of tricellular septate junctions.

Summary: In S. cerevisiae, the length of cytoplasmic microtubule is kept short by Kip2p function during G1-S phase to allow for separation of SPBs and proper chromosome capture.

Summary: Proteasome inhibition induces rapid and significant reductions of APP axonal transport towards synapses due to increased cell body amyloidogenic processing of APP in lysosomes.

Summary: The GTPase ARF6 protects sister chromatid cohesion, allowing the establishment of stable kinetochore-microtubule attachments, SAC satisfaction and mitotic progression.

Summary: The actin and actin-associated protein structures in the sperm tail are revealed by means of STORM. In particular, actin forms a double helix in the midpiece, a novel architectural organization in eukaryotic cells.

Highlighted Article: A genome-wide screen in budding yeast reveals that the functional status of vacuoles is relayed to lipid droplets to regulate their efficient utilization, independently of lipophagy.

Summary: Activation of SMAD1/5/8 via endogenous wild-type ALK2 by activin A, activin B and certain BMPs is enhanced when BMPR2 levels are knocked down.

Highlighted Article: The lectin galectin-3 redistributes β1-integrins and elevates their apical cell surface delivery to promote accurate tubulocyst formation.

Summary: Misfolded SOD1 contributes to ubiquitin proteasome system dysfunction in a cell model of ALS. Hence, ubiquitin homeostasis is an important marker of changes in ALS pathology.

Highlighted Article: Transient receptor potential channel polycystin-2 (PC2) associates with the endosomal sorting complex retromer in a manner that appears to be required for trafficking of PC1 to cilia.

Summary: Pro-inflammatory cytokines IL1β and TNFα promote RANKL-dependent adseverin expression and osteoclastogenesis. A novel method for isolating osteoclast subpopulations based on ploidy status was developed.

TOOLS AND RESOURCES

Summary: Confining RNA-binding proteins on microtubules allows analysis of the mixing and demixing of coexisting RNA-rich sub-compartments with liquid-like properties in living cells.

Close Modal

or Create an Account

Close Modal
Close Modal