Issues
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Cover image
Cover Image
Cover: The centriolar satellite and centrosome protein CCDC66 directly binds to microtubules and changes their organization when overexpressed in cells. Both CCDC66 and CEP290 are mutated in retinal degeneration, and in cells overexpressing CCDC66 ( purple), CEP290 (cyan) is recruited to the microtubules. Nuclei were visualized using DAPI (yellow). See article by D. Conkar et al. (pp. 1450–1462).
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IN THIS ISSUE
STICKY WICKET
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
The tubulin code at a glance
Summary: In this Cell Science at a Glance article and accompanying poster, we present the basic building blocks of the tubulin code.
COMMENTARY
Real-time insights into regulated exocytosis
Summary: This Commentary focuses on recent developments in three-dimensional time-lapse imaging of regulated secretion occurring in living secreting organs.
RESEARCH ARTICLES
Neuropilin 1 binds PDGF-D and is a co-receptor in PDGF-D–PDGFRβ signaling
Highlighted Article: Neuropilin 1 is a co-receptor for PDGF-D, but not PDGF-B, in PDGFRβ signaling. This may represent a new and important aspect in the biology of NRP1 and PDGF-D.
Lineage-specific proteins essential for endocytosis in trypanosomes
Summary: Endocytosis is a vital process in most cells, and here we identify important proteins required for this process in trypanosomes. Significantly, these are unique and not present in animals, fungi or plants.
A functional coupling between CRMP1 and Nav1.7 for retrograde propagation of Semaphorin3A signaling
Highlighted Article: Coupled with CRMP1, Nav1.7 plays a role in mediating retrograde Semaphorin 3A signaling, highlighting its function in signaling from the nerve growth cone to cell body.
GSK3-mediated CLASP2 phosphorylation modulates kinetochore dynamics
Summary: Kinetochore–microtubule interactions are essential for faithful chromosome segregation. Here, we describe consequences of GSK3 phosphorylation-site mutations that control CLASP2 interactions with microtubules during mitosis.
Proline dehydrogenase promotes senescence through the generation of reactive oxygen species
Highlighted Article: This study reveals a new role of proline dehydrogenase in p53-dependent cellular senescence and raises the possibility that an alteration in amino acid metabolism can promote the senescence process.
Evolution of the endomembrane systems of trypanosomatids – conservation and specialisation
Summary: The trafficking systems of trypanosomes are shown to vary considerably, with much minimisation in systems with antigenic variation and more complexity in cell invasive forms.
Neuronal hyperactivity causes Na+/H+ exchanger-induced extracellular acidification at active synapses
Highlighted Article: A novel extracellular pH-indicator that is sensitive to acidic shifts reveals that neuronal hyperactivity causes acidic shifts that are localized to active synapses and generated by the Na+/H+ exchanger.
The centriolar satellite protein CCDC66 interacts with CEP290 and functions in cilium formation and trafficking
Summary: The retinal degeneration gene product CCDC66 is a microtubule-associated protein that localizes to the centrosome and cilium complex, and functions in cilium formation and recruitment of BBS4 to the cilium.
Tex19 paralogs are new members of the piRNA pathway controlling retrotransposon suppression
Summary: In vitro and in vivo experiments demonstrate that the two TEX19 paralogs belong to the family of piRNA-interacting proteins.
Missing-in-metastasis protein downregulates CXCR4 by promoting ubiquitylation and interaction with small Rab GTPases
Summary: MIM promotes CXCR4 ubiquitylation by interacting with AIP4; this interaction is also required for CXCR4 sorting into multivesicular bodies, which is linked to MIM acting as an effector of Rab small GTPases.
Oxidative stress elicited by modifying the ceramide acyl chain length reduces the rate of clathrin-mediated endocytosis
Summary: Altering sphingolipid acyl chain length causes oxidative stress, reducing transcription of Hsc70 via Sp1, which leads to lower levels of Hsc70-mediated uncoating of clathrin-coated vesicles.
ARTICLES OF INTEREST IN OUR OTHER JOURNALS
From Development
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We are welcoming submissions for our upcoming special issue: Cilia and Flagella: from Basic Biology to Disease. This issue will be coordinated by two Guest Editors: Pleasantine Mill (University of Edinburgh) and Lotte Pedersen (University of Copenhagen). Submission deadline: 1 March 2025.
Biologists @ 100 - join us in Liverpool in March 2025
We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate the Spring Meetings of the BSCB and the BSDB, the JEB Symposium Sensory Perception in a Changing World and a DMM programme on antimicrobial resistance. Find out more and register your interest to join us in March 2025 in Liverpool, UK. The deadline for abstract submission and early-bird registration is 17 January 2025.
Fantastic proteins and where to find them – histones, in the nucleus and beyond
In this Review, Johanna Grinat and colleagues provide an evolutionary perspective of histones, nuclear chromatin and extracellular chromatin biology, describing the known extranuclear and extracellular functions of histones.
JCS-FocalPlane Training Grants
Early-career researchers - working in an area covered by JCS - who would like to attend a microscopy training course, please apply. Deadline dates for 2025 applications: 7 March 2025 (decision by week commencing 21 April 2025) and 6 June 2025 (decision by week commencing 28 July 2025).
How to reduce your lab's carbon footprint
All stakeholders – from those working in the lab to those providing funding and infrastructure – have an important role to play to becoming more sustainable. In this Essay, Julie Welburn discusses what lab users can collectively do to transform biomedical research into a discipline that is significantly and positively sustainable.
