Issues
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Cover image
Cover Image
Cover: Cytoskeletal reorganization in B cells spreading on an anti-immunoglobulin-coated coverslip. F-actin (red) accumulates at the cell periphery and the microtubule organising centre (MTOC) relocalises to the central region of the cell from which F-actin has been cleared. Microtubules (blue) and CLIP-170 (green) extend from the MTOC and contact the peripheral ring of F-actin. Imaged by stimulated emission depletion microscopy. See article by J. Wang et al. (pp. 1094–1109).
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IN THIS ISSUE
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
Corneal epithelial stem cells and their niche at a glance
Summary: We summarise the role of the niche microenvironment in regulating corneal epithelial stem cells during homeostasis, repair and disease.
RESEARCH ARTICLES
Derlin-1 promotes ubiquitylation and degradation of the epithelial Na+ channel, ENaC
Summary: Derlin-1 binds to ENaC and promotes its ubiquitylation and degradation via ER-related degradation. The E3 ligase HUWE1 is required and adds K11-linked ubiquitin chains to ENaC prompting its degradation.
Caveolae provide a specialized membrane environment for respiratory syncytial virus assembly
Highlighted Article: The assembly of respiratory syncytial virus occurs in caveolar membranes and caveolar coat components are incorporated into the viral envelope.
The Arabidopsis homolog of Scc4/MAU2 is essential for embryogenesis
Summary: The cohesin-loading complex is evolutionarily conserved across kingdoms. In plants, subunits of the complex are crucial for determining the distribution of auxin maxima and cell fate during embryogenesis.
A RhoG-mediated signaling pathway that modulates invadopodia dynamics in breast cancer cells
Highlighted Article: We describe a novel signaling pathway involving SGEF, RhoG and paxillin phosphorylation, which functions in the regulation of invadopodia disassembly in breast cancer cells.
The Aurora-A–Twist1 axis promotes highly aggressive phenotypes in pancreatic carcinoma
Summary: We show that the AURKA–Twist1 axis regulates EMT, xenograft growth and drug resistance in pancreatic cancer. This is the first mechanism linking AURKA activity with tumor metastasis through Twist1.
The Rap1–cofilin-1 pathway coordinates actin reorganization and MTOC polarization at the B cell immune synapse
Highlighted Article: Consistent with its role as a central regulator of cell polarity, we show that the Rap1 GTPase controls polarization of the microtubule network towards the B cell immune synapse.
The T cell IFT20 interactome reveals new players in immune synapse assembly
Summary: An unbiased mass spectrometry-based analysis of the interactors of the intraflagellar transport protein IFT20 in T cells revealed new vesicular traffic-related regulators of immune synapse assembly.
Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels
Highlighted Article: The ability of volume-regulated heteromeric VRAC channels to conduct organic compounds, including the neurotransmitters glutamate and GABA, depends on LRRC8D and LRRC8E subunits, and suggests new roles in transcellular signal transduction.
Independent mechanisms recruit the cohesin loader protein NIPBL to sites of DNA damage
Summary: Accumulation of NIPBL, the cohesin loader, at different types of DNA lesions occurs through independent mechanisms. This finding enhances our understanding of the highly dynamic roles for NIPBL in genome stability.
Endocytic turnover of Rab8 controls cell polarization
Highlighted Article: GRAF1 mediates inactivation and endocytic removal of Rab8 from cell surface protrusions, thereby facilitating dynamic adjustment of the polarity axis.
miR-450a-5p within rat adipose tissue exosome-like vesicles promotes adipogenic differentiation by targeting WISP2
Summary: Exosome-like vesicles derived from adipose tissue promote adipogenesis through miR-450a-5p by targeting WISP2. This suggests that exosome-like vesicles can be involved in cell-to-cell communication during adipocyte differentiation.
Ypk1 and Ypk2 kinases maintain Rho1 at the plasma membrane by flippase-dependent lipid remodeling after membrane stresses
Summary: Yeast resists plasma membrane stress by maintaining the cortical localization of Rho GTPase through lipid remodeling mediated by Ypk kinase and flippase.
Giant FAZ10 is required for flagellum attachment zone stabilization and furrow positioning in Trypanosoma brucei
Summary: Functional characterization of the T. brucei giant protein FAZ10 reveals it has roles in flagellar attachment, nucleus and kinetoplast positioning and, uniquely for a FAZ protein, a direct role in cytokinesis.
CORRECTIONS
Correction: ICAP-1 monoubiquitylation coordinates matrix density and rigidity sensing for cell migration through ROCK2–MRCKα balance
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