Issues

Summary: Cancer cells have dysregulated pH dynamics and the increased intracellular pH enables a variety of cancer cell behaviors.

Summary: Mitochondrial dynamics, encompassing fission, fusion and transport of the organelle, is precisely regulated and plays important roles in the development and function of the nervous system.

Highlighted Article: Clasp2 is largely confined to the basal progenitor layer of the epidermis. This report shows that Clasp2 ensures mitotic fidelity and holds primary keratinocytes into an undifferentiated state.

Highlighted Article: We quantify non-muscle myosin II dynamics during the coordinated cell movements that drive embryonic wound repair, and demonstrate that mechanical forces and phosphorylation regulate myosin turnover.

Highlighted Article: This paper describes a novel proteomic approach to identify pro-invasive cargoes, which we have used to determine that Rab17 controls Vamp8 levels to drive neuropilin-2 trafficking, promoting invasion.

Summary: The Drosophila spectraplakin Shot coordinates actin–microtubule interactions at the leading edge to ensure the formation of filopodia that promote the dorsal closure of the embryonic epithelium.

Highlighted Article: We show that clustering of the mitotic kinesin-5 Cin8 on microtubules controls its motile properties and directionality, and we provide a refined model of how Cin8 performs its essential functions in mitosis.

Summary: We found that the redox-sensitive TRP channel TRPM2 was present in the phagosomal membrane and that it regulates macrophage bactericidal activity by promoting phagosomal acidification.

Highlighted Article: During neuronal maturation, adenosine-to-inosine RNA editing is regulated by nuclear import of the ADAR2 editing enzyme, which is governed by importin-α4, and nuclear stabilization of ADAR2 by Pin1.

Summary: Leishmania parasites depend on the concerted action of a cytosolic and a cell surface carbonic anhydrase in order to buffer their cytosol and to proliferate in acidic environments.

Summary: Human cactin interacts with spliceosome-associated DHX8 and SRRM2 to support efficient pre-mRNA splicing of thousands of genes, including cohesin-associated CDCA5, and promote chromosome stability.

Summary: The strain avoidance response of cells lacking a functional actin cap, such as in Lmna-deficient cells, is impaired. This suggests a crucial role for the actin cap in strain responsiveness.

Summary: High-content screens identify Pex35, a new peroxisomal membrane protein that regulates peroxisome abundance in yeast. Analysis of Pex35 mutants reveals the functional interaction between peroxisomes and the secretory pathway.

Summary: This study provides genetic evidence that Msi-1 participates in intestinal tumorigenesis driven by tumor suppressor Apc mutations, and implicates Wnt and Notch signaling pathways as mechanistic contributors.