Issues

Summary: This article and accompanying poster provides an outline of the concepts in the assembly of inflammasomes and cell death by pyroptosis.

Summary: A review of the functions of Slit–Robo GTPase-activating proteins (srGAPs), which are highly conserved proteins that interact with the plasma membrane, regulate Rho family GTPases, and function in a wide range of cell biological processes.

Highlighted Article: Here, we show that sensory receptor cargo promotes its intracellular progression by providing input to a specific Arf GEF to activate a cognate Arf directing transport to the cilia.

Summary: ADF10 is an important regulator in shaping the overall organization of apical actin filaments and acts by promoting filament turnover and ordering as well as limiting their length.

Highlighted Article: Two polymorphic membrane proteins that mediate allorecognition in Dictyostelium function as a ligand–receptor pair and their binding activates a signaling mechanism that is required for cooperative aggregation and differentiation.

Summary: Epithelial tissues should permit cell proliferation without losing their integrity for homeostasis. MT2-MMP protease cleaves E-cadherin at apical junctions, promoting regulated exit from quiescence in epithelial cells in the intestine.

Highlighted Article: A S. pombe checkpoint-independent pathway delays activation of the mitotic CDK after UV irradiation through selective translational downregulation of the mitotic cyclin Cdc13.

Summary: The molecular motor KIF13A carries vesicles with influenza A RNA to be packaged into assembling virions, and positively influences localization of vRNPs and virus assembly.

Highlighted Article: The degradation of post-mitotic midbodies is regulated by FYCO1. Without FYCO1, midbodies accumulate, allowing for changes in cell function.

Summary: Dynein and EFF-1 have a non-autonomous function in patterning PVD dendrites in C. elegans through epidermal SAX-7.