IN THIS ISSUE
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
Summary: A review of the functions of Slit–Robo GTPase-activating proteins (srGAPs), which are highly conserved proteins that interact with the plasma membrane, regulate Rho family GTPases, and function in a wide range of cell biological processes.
The Arf GEF GBF1 and Arf4 synergize with the sensory receptor cargo, rhodopsin, to regulate ciliary membrane trafficking
Highlighted Article: Here, we show that sensory receptor cargo promotes its intracellular progression by providing input to a specific Arf GEF to activate a cognate Arf directing transport to the cilia.
ADF10 shapes the overall organization of apical actin filaments by promoting their turnover and ordering in pollen tubes
Summary: ADF10 is an important regulator in shaping the overall organization of apical actin filaments and acts by promoting filament turnover and ordering as well as limiting their length.
The polymorphic proteins TgrB1 and TgrC1 function as a ligand–receptor pair in Dictyostelium allorecognition
Highlighted Article: Two polymorphic membrane proteins that mediate allorecognition in Dictyostelium function as a ligand–receptor pair and their binding activates a signaling mechanism that is required for cooperative aggregation and differentiation.
E-cadherin cleavage by MT2-MMP regulates apical junctional signaling and epithelial homeostasis in the intestine
Summary: Epithelial tissues should permit cell proliferation without losing their integrity for homeostasis. MT2-MMP protease cleaves E-cadherin at apical junctions, promoting regulated exit from quiescence in epithelial cells in the intestine.
Highlighted Article: A S. pombe checkpoint-independent pathway delays activation of the mitotic CDK after UV irradiation through selective translational downregulation of the mitotic cyclin Cdc13.
Summary: The molecular motor KIF13A carries vesicles with influenza A RNA to be packaged into assembling virions, and positively influences localization of vRNPs and virus assembly.
FYCO1 regulates accumulation of post-mitotic midbodies by mediating LC3-dependent midbody degradation
Highlighted Article: The degradation of post-mitotic midbodies is regulated by FYCO1. Without FYCO1, midbodies accumulate, allowing for changes in cell function.
Dynein and EFF-1 control dendrite morphology by regulating the localization pattern of SAX-7 in epidermal cells
Summary: Dynein and EFF-1 have a non-autonomous function in patterning PVD dendrites in C. elegans through epidermal SAX-7.