Issues

Summary: Discussion of the biology of the PIDDosome multiprotein complex and of recent advances that link PIDDosome-dependent CASP2 activation to p53 activation in response to extra centrosomes.

Summary: Centrosomes and cilia are essential structures for many functions in development and disease. This Review discusses how their structure and functions are maintained.

Highlighted Article: Neutrophils and macrophages display distinct modes of interstitial migration in vivo. While neutrophils are classic amoeboid cells, macrophages have a distinct morphology and use a more mesenchymal mode of migration in zebrafish larvae.

Summary: TFCP2L1 interacts with MTA1 to inhibit endoderm specification, while suppressing mesoderm and trophectoderm differentiation, in part, through downregulation of Lef1 expression.

Highlighted Article: LRRC8B participates in cellular Ca²⁺ homeostasis by modulating the endoplasmic reticulum Ca²⁺ leak.

Summary: A novel type of endocytosis signal for type II membrane proteins is encoded in the shape of their transmembrane domains.

Highlighted Article: NEDD4 is an autophagic HECT E3 ubiquitin ligase that ubiquitylates the autophagy receptor SQSTM1, facilitating inclusion body autophagy.

Summary: In addition to the canonical TRC40-targeting pathway, mammalian tail-anchored proteins can also utilise the SRP and SND pathways to facilitate their insertion into the ER membrane.

Highlighted Article: The long-term position of mitotic daughters in the intestinal epithelium correlates with their placement immediately after mitosis. An initial separation at birth, predicts more divergent positions later.

Summary: Pib2 and the EGO complex function in the same molecular pathway that leads to the activation of TORC1, a key regulator of cell growth.

Highlighted Article: This study describes a role for lipid ligand binding by a yeast ORP in exocytic vesicle docking, guiding our understanding of how ORPs may function in more complex organisms.

Summary: A new mechanism that modulates the trafficking of several Ca_V channel subtypes to the plasma membrane through the constitutive activity of the exceptional G-protein-coupled receptor GHSR.

Summary: Analysis of TOEFAZ1, an essential kinetoplastid-specific cytokinetic protein, identifies the function of individual domains and implicates the protein in the positioning and timing of T. brucei cleavage furrow ingression.

Summary: The γ2^pHFAP and MG dye paired optical reporter system is an adaptable fluorescent tool that can be used to simultaneously measure multi-stage GABA_AR trafficking in real-time in living neurons.