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Summary: We explain why talin is amazing, providing a paradigm for how proteins transduce force into protein recruitment, while functioning at many levels in the extracellular matrix–cytoskeleton linkage.

Summary: Spetraplakins are key cytoskeletal crosslinkers that are evolutionarily conserved. This Review summarizes the essential roles these proteins have in coordinating cytoskeletal dynamics in many different cellular processes.


Highlighted Article: Cell surface heparan sulfate is a novel electric field sensor that regulates the galvanotaxis of glial cells through electrophoretic polarization and its function as a co-receptor for chemo-repulsive ligands such as Slit2.

Summary: Evanescence of smooth muscle myosin filaments is involved in the muscle's adaptation to function at different lengths.

Highlighted Article: The DNA damage-inducing agents UVB and UVC, but not X-rays or UVA, activate p38 MAPK and drive EGFR endocytosis without detectable EGFR nuclear translocation. Hence, DNA damage alone is not sufficient to induce EGFR endocytosis.

Summary: Loss of Rab8a and Rab11a trafficking results in severe microvillus atrophy and extensive formation of basolateral microvilli in mice with neonatal enteropathy.

Highlighted Article: As well as operating as an actin assembly factor, the formin DAAM is involved in linking actin remodeling in filopodia to microtubule stabilization during axonal growth in Drosophila.

Summary: Synaptic function and supply of organelles such as vesicles and mitochondria diminish in distal monoaminergic axon terminals.

Highlighted Article: A novel mechanistic model for phagosome formation that is spatiotemporally controlled by Rac1 switching within a phagocytic cup.

Summary: K18 that is resistant to caspase digestion helps to maintain keratin filament organization and delays apoptosis, thereby protecting liver from injury.

Summary: Eliminating the histone chaperone HIRA from mouse skeletal muscle produced a hypertrophic response, compromised sarcolemmal integrity and left muscle fibers that were susceptible to stress-induced degeneration.

Summary: Importin-β and CRM1 regulate the timing of RANBP2 at mitotic kinetochores in opposite ways, with consequences for kinetochore function, including SUMO-conjugated topoisomerase-IIα accumulation and K-fibre stability.

Summary: Rab7 undergoes palmitoylation, a post-translational modification required for endosome-to-TGN trafficking but not for other Rab7 functions.

Summary: Compensatory endocytosis plays key roles in Weibel-Palade body exocytosis. Inhibition of this process results in a change of exocytic mode and the release of von Willebrand factor as tangled strings.

Summary: The adhesion molecule close homolog of L1 (CHL1) is a novel ligand of the hedgehog receptor patched-1. The CHL1–patched-1 interaction promotes survival of cerebellar granule cells during postnatal mouse development.

Summary: The prohibitin (PHB) complex has a novel role in regulating mitoflash activity by affecting respiratory supercomplex formation and, thus, basal mitochondrial ROS production.

Summary: A peroxidase and dual oxidase system generates longevity-promoting ROS at the plasma membrane in C. elegans. Pyrroloquinoline quinone can activate the dual oxidase involved in lifespan extension.


Summary: We present a multi-color bipartite protein reporter for cell surface labeling of receptors. This permits innovative strategies of detection previously difficult or impossible with conventional fluorescent systems.


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