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REVIEWS

Summary: We explain why talin is amazing, providing a paradigm for how proteins transduce force into protein recruitment, while functioning at many levels in the extracellular matrix–cytoskeleton linkage.

Summary: Spetraplakins are key cytoskeletal crosslinkers that are evolutionarily conserved. This Review summarizes the essential roles these proteins have in coordinating cytoskeletal dynamics in many different cellular processes.

RESEARCH ARTICLES

Highlighted Article: Cell surface heparan sulfate is a novel electric field sensor that regulates the galvanotaxis of glial cells through electrophoretic polarization and its function as a co-receptor for chemo-repulsive ligands such as Slit2.

Summary: Evanescence of smooth muscle myosin filaments is involved in the muscle's adaptation to function at different lengths.

Highlighted Article: The DNA damage-inducing agents UVB and UVC, but not X-rays or UVA, activate p38 MAPK and drive EGFR endocytosis without detectable EGFR nuclear translocation. Hence, DNA damage alone is not sufficient to induce EGFR endocytosis.

Summary: Loss of Rab8a and Rab11a trafficking results in severe microvillus atrophy and extensive formation of basolateral microvilli in mice with neonatal enteropathy.

Highlighted Article: As well as operating as an actin assembly factor, the formin DAAM is involved in linking actin remodeling in filopodia to microtubule stabilization during axonal growth in Drosophila.

Summary: Synaptic function and supply of organelles such as vesicles and mitochondria diminish in distal monoaminergic axon terminals.

Highlighted Article: A novel mechanistic model for phagosome formation that is spatiotemporally controlled by Rac1 switching within a phagocytic cup.

Summary: K18 that is resistant to caspase digestion helps to maintain keratin filament organization and delays apoptosis, thereby protecting liver from injury.

Summary: Eliminating the histone chaperone HIRA from mouse skeletal muscle produced a hypertrophic response, compromised sarcolemmal integrity and left muscle fibers that were susceptible to stress-induced degeneration.

Summary: Importin-β and CRM1 regulate the timing of RANBP2 at mitotic kinetochores in opposite ways, with consequences for kinetochore function, including SUMO-conjugated topoisomerase-IIα accumulation and K-fibre stability.

Summary: Rab7 undergoes palmitoylation, a post-translational modification required for endosome-to-TGN trafficking but not for other Rab7 functions.

Summary: Compensatory endocytosis plays key roles in Weibel-Palade body exocytosis. Inhibition of this process results in a change of exocytic mode and the release of von Willebrand factor as tangled strings.

Summary: The adhesion molecule close homolog of L1 (CHL1) is a novel ligand of the hedgehog receptor patched-1. The CHL1–patched-1 interaction promotes survival of cerebellar granule cells during postnatal mouse development.

Summary: The prohibitin (PHB) complex has a novel role in regulating mitoflash activity by affecting respiratory supercomplex formation and, thus, basal mitochondrial ROS production.

Summary: A peroxidase and dual oxidase system generates longevity-promoting ROS at the plasma membrane in C. elegans. Pyrroloquinoline quinone can activate the dual oxidase involved in lifespan extension.

TOOLS AND RESOURCES

Summary: We present a multi-color bipartite protein reporter for cell surface labeling of receptors. This permits innovative strategies of detection previously difficult or impossible with conventional fluorescent systems.

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