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IN THIS ISSUE

STICKY WICKET

CELL SCIENTISTS TO WATCH

MEETING REPORT

COMMENTARIES

Summary: We discuss recent advances in the regulation of the lamina-independent pool of lamins in the nucleoplasm and their emerging functions in chromatin organization, mechanical regulation and disease.

Summary: During cell division, kinesin-14 motors are conserved regulators of spindle assembly and chromosome segregation. We provide a detailed view of their cellular functions in diverse organisms.

SHORT REPORT

Summary: The nuclear lamina regulates SRF−Mkl1 activity specifically in cells grown within stiff mechanical environments.

RESEARCH ARTICLES

Highlighted Article: Phosphatidylinositol 5-phosphate 4-kinase regulates early endosomal dynamics and trafficking of plasma membrane receptors through clathrin-mediated endocytosis in Drosophila cells.

Summary: Differentiation of nociceptors relies on transcription factors, receptors and neuropeptides. We identify the importance of intracellular signaling, including pathways involved in neuronal memory, for postnatal nociceptor maturation.

Highlighted Article: Analysis of Drosophila crb mutations demonstrates that the Crb extracellular region controls protein level and distribution, and suggests that human disease-causing CRB1 missense mutations affect rhodopsin trafficking.

Summary: WLS and SEC12 form a stable complex on ER membrane that binds to mature Wnt molecules. We find that several independent protein motifs within WLS are essential for the association of this complex with COPII ER-exiting machinery.

Highlighted Article: The cell−matrix adapter protein Tns3 is identified as a determinant of adhesion plasticity in subcultures of cancer cells. Tns3 gene expression constitutes a feedback loop controling cell adhesion and motility.

Summary: The mechanism through which macromolecular complexes reach the nuclear pores is incompletely understood. We show that the cytoplasmic perinuclear ecology is tuned by CRM1 to control virus transport to the nuclear pore complex.

Highlighted Article: TRPV4 is a Ca2+-permeable channel in the plasma membrane that regulates FliI–NMMIIA interactions, which in turn affects the cell extension formation necessary for the control of collagen remodeling and matrix biology.

Summary: The selective distribution of the cell adhesion molecules Caspr2 and TAG-1 might be responsible for positioning of Kv1 channels at the axon initial segment versus along the axon in hippocampal neurons.

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