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IN THIS ISSUE

CELL SCIENTISTS TO WATCH

COMMENTARIES

Summary: Microbial pathogens have developed a variety of strategies, both conventional and unconventional, to exploit and interfere with the ubiquitylation machinery of infected host cells.

Summary: This Commentary discusses poorly appreciated paradigms of how DUBs are activated, regulated and targeted to their appropriate substrates to achieve precise spatio-temporal control of ubiquitin signals within a specific biological pathway.

RESEARCH ARTICLES

Summary: Rab5 recruits the Vps34-containing PI3K to regulate endosome trafficking. We identified a negative feedback loop whereby C. elegans VPS-34 recruits the TBC-2 RAB-5 GAP to endosomes to inactivate RAB-5 during endosome maturation.

Highlighted Article: The estrogen-regulated growth factor amphiregulin, which is necessary for post-pubertal mammary gland ductal elongation, is not required for reprogramming non-mammary stem cells to a mammary cell fate.

Summary: Bone erosion requires that osteoclasts both resorb and migrate. According to common belief, these activities are mutually exclusive and alternate. Paradoxically, we show here simultaneous resorption and migration.

Highlighted Article: Induction of ADAM12 by Twist1 promotes invadopodia formation and focal adhesion turnover to facilitate Twist1-induced cell migration, invasion and tumor metastasis.

Summary: Using a novel system to identify cell growth regulators, we have discovered a number of factors that activate growth in cells in which growth is developmentally switched off.

Highlighted Article: We show that Kif5b can compensate for defects in myosin-Va-based transport in mammals, but that endogenous Kif5b plays a minimal role in transport in melanocytes due to inefficient recruitment to melanosomes.

TOOLS AND TECHNIQUES

Summary: We combined super-resolution microscopy with robust image analyses to discern the organization of chromatin at nuclear pore complexes. This demonstrated the importance of image analysis to enhance super-resolution techniques.

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