IN THIS ISSUE
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
Summary: Here, we give readers an overview of the biology and characteristics of pseudostratified epithelia.
Caught in the act – protein adaptation and the expanding roles of the PACS proteins in tissue homeostasis and disease
Summary: We summarize how the vertebrate PACS proteins acquired specific motifs that enabled them to function as metabolic switches that integrate cytoplasmic membrane trafficking and interorganellar communication with nuclear gene expression.
Highlighted Article: SNAP-25 family members differentially support neuron survival, and dense-core and synaptic vesicle fusion in Snap-25-null mutant neurons.
Summary: In the presence of canonical Wnt proteins, the regulator of planar cell polarity PTK7 is endocytosed and degraded in lysosomes. By contrast, PTK7 inhibits canonical Wnt signaling suggesting a mechanism of mutual inhibition.
Highlighted Article: We develop a new method to track vesicle dynamics in three dimensions and show that vesicles change their position while actively transporting along microtubules in living cells to overcome obstacles.
Spatiotemporal regulation of cell fusion by JNK and JAK/STAT signaling during Drosophila wound healing
Summary: During Drosophila wound healing, JAK/STAT signaling restricts cell fusion to the periphery of the wound, whereas in the wound vicinity, JAK/STAT signaling is inhibited by fusion-promoting JNK signaling.
A novel ATP-synthase-independent mechanism coupling mitochondrial activation to exocytosis in insulin-secreting cells
Highlighted Article: Secretagogues stimulating mitochondria in pancreatic β-cells act by two different mechanisms to promote insulin secretion. The pathways are distinct in their dependence on ATP-synthase, Ca2+ signals and redox changes.
Summary: Mitochondrial distribution within the cell is critical for supplying ATP at specific sites. We show here that CLUH couples mitochondrial distribution to the energetic and metabolic status in human cells.
Highlighted Article: p38-MAPK-mediated induction of NOTCH3 is required for prostate epithelial differentiation; this is mediated in part via MYC and enhancer-driven transcription, as well as enhanced mRNA stability.
Transient mechanical strain promotes the maturation of invadopodia and enhances cancer cell invasion in vitro
Summary: Tugging on ECM fibers promotes the maturation of invadopodia and cell invasion in highly invasive cancer cells. This specific form of mechanical signaling downregulates integrin β3 resulting in increased cofilin activity.