IN THIS ISSUE
CELL SCIENCE AT A GLANCE
Summary: Prognostic assays based on proliferation (e.g. Oncotype DX, MammaPrint DX) combined with a prognostic derived from a signature of dissemination (e.g. TMEM score) could provide a complementary and more personalized prognostic information for breast cancer patients.
Summary: This Commentary defines invadosomes and illustrates their plasticity, which depends on various factors, including the matrix microenvironment.
CEP164-null cells generated by genome editing show a ciliation defect with intact DNA repair capacity
Summary: Knockout of the CEP164 ciliopathy gene ablates ciliogenesis but causes no increase in sensitivity to DNA damage induced by ionising or ultraviolet irradiation.
Summary: This study reveals that the cleavage of the LUBAC subunit HOIL1 by the paracaspase MALT1 participates in T-cell receptor signaling.
Impaired mechanical response of an EDMD mutation leads to motility phenotypes that are repaired by loss of prenylation
Highlighted Article: Worms expressing the L535P Emery–Dreifuss muscular dystrophy lamin mutation show muscle phenotypes and muscle-specific abnormal responses to mechanical strain, which depend on emerin and UNC-84, and are rescued by loss of prenylation.
Summary: Monomeric and oligomeric α-synuclein induce Ca2+ signal in neurons and astrocytes by incorporating into the membrane.
Highlighted Article: By interacting with PlexA4, TrkA plays a crucial role in redirecting local Sema3A signaling to retrograde axonal transport, thereby regulating dendritic GluA2 localization and patterning.
Cdk5–Foxo3 axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models
Summary: The Cdk5–Foxo3 axis promotes neurotoxic β-amyloid processing and neuronal death in Alzheimer's disease models.
Highlighted Article: We find FAM3D is a new endogenous agonist of FPR1 and FPR2, and chemoattracts neutrophils and monocytes.
Summary: Force transduction at E-cadherin junctions operates in addition to unfurling of cadherin-associated α-catenin. This pathway requires EGFR and triggers the downstream activation of integrin-dependent cell contractility.
TAK1 determines susceptibility to endoplasmic reticulum stress and leptin resistance in the hypothalamus
Highlighted Article: Deficiency of the protein kinase Tak1 protects cells against endoplasmic reticulum stress through activation of de novo lipogenesis, which prevents leptin resistance in the hypothalamus and hyperphagic obesity.
Summary: ARMS and synembryn-B levels regulate NGF-mediated secretion and are tightly regulated during development, promoting differentiation and keeping regulated secretion under control.
Cell adhesion molecule L1 contributes to neuronal excitability regulating the function of voltage-gated Na+ channels
Highlighted Article: We uncovered a new role of L1CAM in the functional expression and localization of Na+ channels to the plasma membrane, ensuring correct initiation of action potential and normal firing activity.
Summary: This study shows that stressors that burden the proteostatic network produce the greatest impact on newly made proteins with a substantial portion of the proteome being vulnerable to such stress.
Summary: Glucose can be delivered between astrocytes and oligodendrocytes through gap junction channels, and spontaneous intracellular Ca2+ signaling triggers connexin hemichannel activity that enables glucose uptake in OPCs.
Epiboly generates the epidermal basal monolayer and spreads the nascent mammalian skin to enclose the embryonic body
Summary: The nascent mammalian epidermis spreads to enclose the embryo trunk through a process akin to epiboly, which has important implications for human birth defects of the abdominal wall.
Summary: This paper describes a new mechanism whereby the terminal part of complement (the membrane attack complex) can trigger host NLRP3 inflammasome activation.
Summary: Mice deficient in CNNM4, a Mg2+ transporter, are infertile because this protein regulates sperm Ca2+ homeostasis during the process of capacitation.