Issues
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Cover image
Cover Image
Cover: The ‘creation of nerve impulse’ by Saray López-Benito. The illustration is an analogy of ‘The Creation of Adam’ fresco painting by Michelangelo. It shows two neurons during the differentiation process creating a connection between them for the transmission of nerve impulses. See article by S. López-Benito et al. (pp. 1866–1877).
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IN THIS ISSUE
CELL SCIENCE AT A GLANCE
Signatures of breast cancer metastasis at a glance
Summary: Prognostic assays based on proliferation (e.g. Oncotype DX, MammaPrint DX) combined with a prognostic derived from a signature of dissemination (e.g. TMEM score) could provide a complementary and more personalized prognostic information for breast cancer patients.
COMMENTARY
The microenvironment controls invadosome plasticity
Summary: This Commentary defines invadosomes and illustrates their plasticity, which depends on various factors, including the matrix microenvironment.
SHORT REPORTS
CEP164-null cells generated by genome editing show a ciliation defect with intact DNA repair capacity
Summary: Knockout of the CEP164 ciliopathy gene ablates ciliogenesis but causes no increase in sensitivity to DNA damage induced by ionising or ultraviolet irradiation.
The paracaspase MALT1 cleaves the LUBAC subunit HOIL1 during antigen receptor signaling
Summary: This study reveals that the cleavage of the LUBAC subunit HOIL1 by the paracaspase MALT1 participates in T-cell receptor signaling.
RESEARCH ARTICLES
Impaired mechanical response of an EDMD mutation leads to motility phenotypes that are repaired by loss of prenylation
Highlighted Article: Worms expressing the L535P Emery–Dreifuss muscular dystrophy lamin mutation show muscle phenotypes and muscle-specific abnormal responses to mechanical strain, which depend on emerin and UNC-84, and are rescued by loss of prenylation.
Ca2+ is a key factor in α-synuclein-induced neurotoxicity
Summary: Monomeric and oligomeric α-synuclein induce Ca2+ signal in neurons and astrocytes by incorporating into the membrane.
TrkA mediates retrograde semaphorin 3A signaling through plexin A4 to regulate dendritic branching
Highlighted Article: By interacting with PlexA4, TrkA plays a crucial role in redirecting local Sema3A signaling to retrograde axonal transport, thereby regulating dendritic GluA2 localization and patterning.
Cdk5–Foxo3 axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models
Summary: The Cdk5–Foxo3 axis promotes neurotoxic β-amyloid processing and neuronal death in Alzheimer's disease models.
Identification of FAM3D as a new endogenous chemotaxis agonist for the formyl peptide receptors
Highlighted Article: We find FAM3D is a new endogenous agonist of FPR1 and FPR2, and chemoattracts neutrophils and monocytes.
E-cadherin-mediated force transduction signals regulate global cell mechanics
Summary: Force transduction at E-cadherin junctions operates in addition to unfurling of cadherin-associated α-catenin. This pathway requires EGFR and triggers the downstream activation of integrin-dependent cell contractility.
TAK1 determines susceptibility to endoplasmic reticulum stress and leptin resistance in the hypothalamus
Highlighted Article: Deficiency of the protein kinase Tak1 protects cells against endoplasmic reticulum stress through activation of de novo lipogenesis, which prevents leptin resistance in the hypothalamus and hyperphagic obesity.
ARMS/Kidins220 and synembryn-B levels regulate NGF-mediated secretion
Summary: ARMS and synembryn-B levels regulate NGF-mediated secretion and are tightly regulated during development, promoting differentiation and keeping regulated secretion under control.
Cell adhesion molecule L1 contributes to neuronal excitability regulating the function of voltage-gated Na+ channels
Highlighted Article: We uncovered a new role of L1CAM in the functional expression and localization of Na+ channels to the plasma membrane, ensuring correct initiation of action potential and normal firing activity.
Vulnerability of newly synthesized proteins to proteostasis stress
Summary: This study shows that stressors that burden the proteostatic network produce the greatest impact on newly made proteins with a substantial portion of the proteome being vulnerable to such stress.
Connexin-based channels contribute to metabolic pathways in the oligodendroglial lineage
Summary: Glucose can be delivered between astrocytes and oligodendrocytes through gap junction channels, and spontaneous intracellular Ca2+ signaling triggers connexin hemichannel activity that enables glucose uptake in OPCs.
Epiboly generates the epidermal basal monolayer and spreads the nascent mammalian skin to enclose the embryonic body
Summary: The nascent mammalian epidermis spreads to enclose the embryo trunk through a process akin to epiboly, which has important implications for human birth defects of the abdominal wall.
Complement-mediated ‘bystander’ damage initiates host NLRP3 inflammasome activation
Summary: This paper describes a new mechanism whereby the terminal part of complement (the membrane attack complex) can trigger host NLRP3 inflammasome activation.
The Mg2+ transporter CNNM4 regulates sperm Ca2+ homeostasis and is essential for reproduction
Summary: Mice deficient in CNNM4, a Mg2+ transporter, are infertile because this protein regulates sperm Ca2+ homeostasis during the process of capacitation.
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Special Issue – Cell Biology of Mitochondria

Our special issue on ‘Cell Biology of Mitochondria’ is now complete. Explore this issue and read the Editorial from our Guest Editors Ana J. García-Sáez and Heidi McBride.
Save the date – Imaging Cell Dynamics

We are delighted to announce that we will be hosting a 2026 Imaging Cell Dynamics meeting. This meeting will provide a unique opportunity to bring together experts working at the interface between cell biology and imaging. Save the date for 11-14 May 2026 and register for more information.
Origin and evolution of mitochondrial inner membrane composition

In this Review, Kailash Venkatraman and colleagues provide an examination of the morphological similarities between prokaryotic intracytoplasmic membranes and mitochondrial inner membranes, and whether cristae evolution has driven specialisation of the mitochondrial lipidome.
Resolution in super-resolution microscopy
Super-resolution microscopy (SRM) has emerged as a powerful tool for biological discovery. In this Perspective, Kirti Prakash and colleagues compile expert opinions on crucial, yet often overlooked, aspects of SRM that are essential for maximising its benefits and advancing the field.