Issues

Summary: In humans, nonsense-mediated mRNA decay prevents the synthesis of potentially toxic proteins from mutated mRNAs, and also regulates 10% of physiological mRNAs that promote cellular adaptation to changing environments.

Summary: Visualization of macromolecules, organelles and cells by cryo-ET allows for structural analysis in a near-native environment. Recent technological advances have revealed unprecedented structural details.

Summary: In Drosophila, p120-catenin facilitates endocytosis of the dynamic E-cadherin, which is followed by its recycling. Consequently, p120-catenin regulates cell shape and promotes the ability of cells to exchange neighbours.

Highlighted Article: Insulin growth factor 1 (IGF1) activation mediates changes in cellular contractility and migration in single-suture craniosynostosis (SSC) osteoblasts.

Summary: Conditional knockout of Htt in the male germ cells reveals that Htt might play an important role in spermatogenesis by regulating translation and DNA packaging in the testis.

Highlighted Article: Emerin is a tail-anchored protein of the inner nuclear membrane. Here, post-translational membrane insertion of emerin is analyzed, revealing a prominent role for the TRC40 pathway.

Summary: A peptide mimetic of the p75^NTR intracellular domain potentiates the survival of motor neurons in vivo by redressing the neurotrophin signaling imbalance in neurodegenerative conditions.

Highlighted Article: Although Drosophila lacks a Rec8 homologue, the Rec8-specific protease, Separase and its regulator, Securin are essential for release of cohesion.

Summary: Myo19 is an effector of starvation-induced filopodia formation and is directly anchored to the outer mitochondrial membrane.

Highlighted Article: SEZ6L2 participates in the intracellular trafficking of the hydrolase cathepsin D. In turn, proteolytic cleavage of SEZ6L2 by cathepsin D modulates the neurite outgrowth process.

Summary: FGF2 induces the expression of miR-20a, which targets the TGFβ receptor complex and abolishes endothelial–mesenchymal transition, a process that has a major role in fibroproliferative diseases.

Summary: RNF168 was identified as a negative regulator of PML nuclear bodies, and shown to associate with PML nuclear bodies and hybrid SUMO2–ubiquitin chains.

Summary: The role of MyRIP in restricting the movement and exocytosis of Weibel–Palade bodies in endothelial cells is mediated primarily through its actin- rather than myosin-Va-binding properties.

Summary: Here, we characterize WHAMY, the fourth member of the Drosophila WASP family. We found that WHAMY is a novel actin polymerase.

Summary: WDR8 is a centriolar and pericentriolar satellite protein. WDR8 is targeted to the centrioles by the proximal end protein Cep135. Cep135 and WDR8 are required for ciliary-vesicle docking during ciliogenesis.

Summary: The insulin secretagogue glucose activates PI3K and induces endocytosis through promoting signaling crosstalk between Arf6 and Rab27a pathways.