IN THIS ISSUE
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
The role and regulation of Rab40b–Tks5 complex during invadopodia formation and cancer cell invasion
Highlighted Article: Rab40b plays a key role in mediating invadopodia function during breast cancer cell invasion by binding to Tks5 and functioning as a tether mediating MMP2 and MMP9 targeting to the extending invadopodia.
Drosophila vinculin is more harmful when hyperactive than absent, and can circumvent integrin to form adhesion complexes
Summary: Development is more sensitive to gain of vinculin activity than its loss, and vinculin can promote cytoplasmic adhesion complexes independently of the usual integrin cue.
Highlighted Article: The functional impact of missense mutations is difficult to predict. Yeast cells detect the misfolding effects of these types of mutations in the human BRCA1 protein, revealing an associated nuclear transport impairment.
Summary: Removal of Cabyr by using CRISPR-Cas9 results in mouse spermatozoa with a disorganized fibrous sheath, impaired motility and a subsequent loss of their ability to fertilize oocytes.
Junctophilin-2 in the nanoscale organisation and functional signalling of ryanodine receptor clusters in cardiomyocytes
Highlighted Article: The availability of the membrane tether junctophilin-2 determines the nanostructure of the fast intracellular Ca2+ signalling junctions but, if present above a minimum required level, forms an auto-regulatory mechanism which maintains local Ca2+ signals broadly independent of the structural differences.
Cell coupling mediated by connexin 26 selectively contributes to reduced adhesivity and increased migration
Summary: Gap junction expression has been linked to enhanced metastasis and cell migration. We show here that Cx26 gap junctions selectively enhance cell migration by disrupting N-cadherin-based cell adhesion in HeLa cells.
Acute stimulation of glucose influx upon mitoenergetic dysfunction requires LKB1, AMPK, Sirt2 and mTOR–RAPTOR
Highlighted Article: Dysfunction of mitochondria and subsequently energy generation occurs in many human diseases. Here, we propose a mechanism that allows rapid activation of glucose influx to prevent energy crisis during such dysfunction.
Vps34 regulates Rab7 and late endocytic trafficking through recruitment of the GTPase-activating protein Armus
Summary: The class III PI3K Vps34 activates Armus (TBC1D2), a Rab7 GTPase-activating protein, to regulate endosomal trafficking.