Issues
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Close ModalCover: Localization of oskar (osk) mRNA at the posterior of Drosophila oocytes is required for establishing the anterior–posterior polarity of the oocyte and the resulting embryo. The image shows fluorescent in situ hybridization of osk mRNA (red) in mutants deficient for a unique isoform of non-muscle tropomyosin (nuclei are shown in cyan). In these mutants, osk is delocalized throughout the oocyte with an enrichment around the cortex. See article by Veeranan-Karmegam R., et al. (pp. 4252–4264).
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IN THIS ISSUE
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
The integrin adhesome network at a glance
Summary: We have generated a new depiction of the integrin adhesome network that integrates experimentally derived IAC proteomes with the literature-curated adhesome to bridge the knowledge gap between these two resources.
COMMENTARY
Emerging biological roles of Cl− intracellular channel proteins
Summary: Emerging evidence points to a role of CLIC proteins in actin dynamics and membrane trafficking.
RESEARCH ARTICLES
Ligand-induced growth and compaction of CD36 nanoclusters enriched in Fyn induces Fyn signaling
Highlighted Article: The receptor CD36 exists in nanoclusters enriched with the downstream effector Fyn when unligated; multivalent ligands enhance the clusters and activate Fyn, bypassing de novo recruitment of Fyn to the clusters.
Phosphorylation of STAT2 on serine-734 negatively regulates the IFN-α-induced antiviral response
Summary: Phosphorylation of STAT2 at S724 selectively regulates the antiviral, but not the anti-proliferative, effects of type I interferons (IFNs) by limiting the expression of a select subset of IFN-stimulated genes.
ELYS regulates the localization of LBR by modulating its phosphorylation state
Highlighted Article: The nuclear envelope localization of LBR is regulated through a phosphorylation network governed by ELYS, and defects in this phosphorylation network induce the aberrant phosphorylation and mislocalization of LBR.
HIF-2α phosphorylation by CK1δ promotes erythropoietin secretion in liver cancer cells under hypoxia
Summary: Phosphorylation of hypoxia inducible factor 2α mediated by casein kinase 1δ increases erythropoietin production by impairing a CRM1-dependent nuclear export mechanism in liver cancer cells.
Nuclear alignment in myotubes requires centrosome proteins recruited by nesprin-1
Highlighted Article: Nuclear positioning in myotubes requires centrosome proteins recruited early in differentiation to the nuclear envelope in a nesprin-1-dependent manner. These contribute to the recruitment of microtubule motor proteins.
Acid sphingomyelinase is required for cell surface presentation of Met receptor tyrosine kinase in cancer cells
Summary: Acid sphingomyelinase (ASM) regulates the cell surface levels of Met receptor tyrosine kinase through selective regulation of the exit of Met from the Golgi.
A new isoform of Drosophila non-muscle Tropomyosin 1 interacts with Kinesin-1 and functions in oskar mRNA localization
Highlighted Article: A previously uncharacterized isoform of Tropomyosin, referred to as Tm1C, directly interacts with Kinesin heavy chain and functions along with this microtubule motor to localize oskar mRNA in Drosophila oocytes.
The C-terminal domain of Kv1.3 regulates functional interactions with the KCNE4 subunit
Summary: Kv1.3 and KCNE4 form functional channels in leukocytes. KCNE4 associates with the C-terminal domain of Kv1.3 providing two independent and additive mechanisms for the intracellular retention of the complex.
Control of apico–basal epithelial polarity by the microtubule minus-end-binding protein CAMSAP3 and spectraplakin ACF7
Highlighted Article: The spectraplakin ACF7 and microtubule minus-end-stabilizing protein CAMSAP3 cooperate in organizing non-centrosomal microtubule arrays in intestinal epithelial cells.
Atg20- and Atg24-family proteins promote organelle autophagy in fission yeast
Summary: Fission yeast Atg20- and Atg24-family proteins promote starvation-induced autophagy of ER and mitochondria, and we propose that their function is to ensure that autophagosomes are of a sufficient size.
HMGB2 regulates satellite-cell-mediated skeletal muscle regeneration through IGF2BP2
Summary: HMGB2 promotes myoblast proliferation and muscle regeneration through IGF2BP2, which regulates the protein production of cyclin A2 and Myf5.
CORRECTION
ARTICLES OF INTEREST IN OUR OTHER JOURNALS
From Development
'FocalPlane features...' webinar series
We’re excited to announce the new 'FocalPlane features…' webinar series. Covering all aspects of microscopy, join us on the first Tuesday of every month to hear about the latest research and take part in a virtual networking session with the speaker afterwards.
Save your spot at our next sessions:
1 June
Speaker: Pavel Tomancak
6 July
Speaker: Eva Nogales
3 August
Speaker: Michael Dustin
Meet the JCS Editors
Although in-person meetings are still on hold, we’re always happy to chat about JCS and The Company of Biologists. Our Editors are out and about, virtually of course, throughout May and June:
Mate Palfy (Features & Reviews Editor)
EMBL Chromatin and Epigenetics
17 - 20 May
Petra Gross (Senior Editor)
Cell Polarity and Membrane Dynamics
16 - 21 May
Targeted Protein Degradation: From Small Molecules to Complex Organelles
6 – 9 June
Sharon Ahmad (Executive Editor)
SIBBM 2021 – Frontiers in Molecular Biology
7 – 10 June
Cell scientist to watch - Julia Cordero
Julia Cordero shares her fascinating journey in science, from Argentina, to the USA and now Scotland, where she works across fly and mouse systems to investigate functions of the adult intestine in health and disease.
Mole - The Corona Files
"We are one year in, and not out of this yet."
Mole continues to offer his wise words to researchers on how to manage during the COVID-19 pandemic.
