Issues
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Cover image
Cover Image
Cover: Localization of oskar (osk) mRNA at the posterior of Drosophila oocytes is required for establishing the anterior–posterior polarity of the oocyte and the resulting embryo. The image shows fluorescent in situ hybridization of osk mRNA (red) in mutants deficient for a unique isoform of non-muscle tropomyosin (nuclei are shown in cyan). In these mutants, osk is delocalized throughout the oocyte with an enrichment around the cortex. See article by Veeranan-Karmegam R., et al. (pp. 4252–4264).
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IN THIS ISSUE
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
The integrin adhesome network at a glance
Summary: We have generated a new depiction of the integrin adhesome network that integrates experimentally derived IAC proteomes with the literature-curated adhesome to bridge the knowledge gap between these two resources.
COMMENTARY
Emerging biological roles of Cl− intracellular channel proteins
Summary: Emerging evidence points to a role of CLIC proteins in actin dynamics and membrane trafficking.
RESEARCH ARTICLES
Ligand-induced growth and compaction of CD36 nanoclusters enriched in Fyn induces Fyn signaling
Highlighted Article: The receptor CD36 exists in nanoclusters enriched with the downstream effector Fyn when unligated; multivalent ligands enhance the clusters and activate Fyn, bypassing de novo recruitment of Fyn to the clusters.
Phosphorylation of STAT2 on serine-734 negatively regulates the IFN-α-induced antiviral response
Summary: Phosphorylation of STAT2 at S724 selectively regulates the antiviral, but not the anti-proliferative, effects of type I interferons (IFNs) by limiting the expression of a select subset of IFN-stimulated genes.
ELYS regulates the localization of LBR by modulating its phosphorylation state
Highlighted Article: The nuclear envelope localization of LBR is regulated through a phosphorylation network governed by ELYS, and defects in this phosphorylation network induce the aberrant phosphorylation and mislocalization of LBR.
HIF-2α phosphorylation by CK1δ promotes erythropoietin secretion in liver cancer cells under hypoxia
Summary: Phosphorylation of hypoxia inducible factor 2α mediated by casein kinase 1δ increases erythropoietin production by impairing a CRM1-dependent nuclear export mechanism in liver cancer cells.
Nuclear alignment in myotubes requires centrosome proteins recruited by nesprin-1
Highlighted Article: Nuclear positioning in myotubes requires centrosome proteins recruited early in differentiation to the nuclear envelope in a nesprin-1-dependent manner. These contribute to the recruitment of microtubule motor proteins.
Acid sphingomyelinase is required for cell surface presentation of Met receptor tyrosine kinase in cancer cells
Summary: Acid sphingomyelinase (ASM) regulates the cell surface levels of Met receptor tyrosine kinase through selective regulation of the exit of Met from the Golgi.
A new isoform of Drosophila non-muscle Tropomyosin 1 interacts with Kinesin-1 and functions in oskar mRNA localization
Highlighted Article: A previously uncharacterized isoform of Tropomyosin, referred to as Tm1C, directly interacts with Kinesin heavy chain and functions along with this microtubule motor to localize oskar mRNA in Drosophila oocytes.
The C-terminal domain of Kv1.3 regulates functional interactions with the KCNE4 subunit
Summary: Kv1.3 and KCNE4 form functional channels in leukocytes. KCNE4 associates with the C-terminal domain of Kv1.3 providing two independent and additive mechanisms for the intracellular retention of the complex.
Control of apico–basal epithelial polarity by the microtubule minus-end-binding protein CAMSAP3 and spectraplakin ACF7
Highlighted Article: The spectraplakin ACF7 and microtubule minus-end-stabilizing protein CAMSAP3 cooperate in organizing non-centrosomal microtubule arrays in intestinal epithelial cells.
Atg20- and Atg24-family proteins promote organelle autophagy in fission yeast
Summary: Fission yeast Atg20- and Atg24-family proteins promote starvation-induced autophagy of ER and mitochondria, and we propose that their function is to ensure that autophagosomes are of a sufficient size.
HMGB2 regulates satellite-cell-mediated skeletal muscle regeneration through IGF2BP2
Summary: HMGB2 promotes myoblast proliferation and muscle regeneration through IGF2BP2, which regulates the protein production of cyclin A2 and Myf5.
CORRECTION
ARTICLES OF INTEREST IN OUR OTHER JOURNALS
From Development
2021 JCS Prize winner announced
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We are pleased to announce that the winner of the 2021 JCS Prize is Lee Dolat for his paper entitled ‘An endometrial organoid model of interactions between Chlamydia and epithelial and immune cells’.
Propose a new Workshop
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Our Workshops bring together leading experts and early-career researchers from a range of scientific backgrounds. Applications are now open to propose Workshops for 2024, one of which will be held in a Global South country.
Cell scientist to watch: Christian Münch
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Journal of Cell Science interviewed Christian Münch, who established his independent research group in 2016 at Goethe University Frankfurt. His lab studies cellular stress responses to mitochondrial protein misfolding, infection and disease, as well as developing proteomics methods.
Essay series: Equity, diversity and inclusion in cell biology
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The JCS Essay Series is an initiative to help showcase and provide a platform for voices in the field of cell biology. The first topic we covered was 'Equity, diversity and inclusion in cell biology', and the winning and runner up essays are now available to read.
FocalPlane Network launched
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We are excited to announce the launch of the FocalPlane Network, an international directory of microscopists. The idea behind the FocalPlane Network is to facilitate promotion and networking as well as assist those seeking conference speakers, committee members, reviewers or collaborators. We hope that it will help promote diversity in the community. Find out more and join the Network here.