Issues

Summary: We have generated a new depiction of the integrin adhesome network that integrates experimentally derived IAC proteomes with the literature-curated adhesome to bridge the knowledge gap between these two resources.

Summary: Emerging evidence points to a role of CLIC proteins in actin dynamics and membrane trafficking.

Highlighted Article: The receptor CD36 exists in nanoclusters enriched with the downstream effector Fyn when unligated; multivalent ligands enhance the clusters and activate Fyn, bypassing de novo recruitment of Fyn to the clusters.

Summary: Phosphorylation of STAT2 at S724 selectively regulates the antiviral, but not the anti-proliferative, effects of type I interferons (IFNs) by limiting the expression of a select subset of IFN-stimulated genes.

Highlighted Article: The nuclear envelope localization of LBR is regulated through a phosphorylation network governed by ELYS, and defects in this phosphorylation network induce the aberrant phosphorylation and mislocalization of LBR.

Summary: Phosphorylation of hypoxia inducible factor 2α mediated by casein kinase 1δ increases erythropoietin production by impairing a CRM1-dependent nuclear export mechanism in liver cancer cells.

Highlighted Article: Nuclear positioning in myotubes requires centrosome proteins recruited early in differentiation to the nuclear envelope in a nesprin-1-dependent manner. These contribute to the recruitment of microtubule motor proteins.

Summary: Acid sphingomyelinase (ASM) regulates the cell surface levels of Met receptor tyrosine kinase through selective regulation of the exit of Met from the Golgi.

Highlighted Article: A previously uncharacterized isoform of Tropomyosin, referred to as Tm1C, directly interacts with Kinesin heavy chain and functions along with this microtubule motor to localize oskar mRNA in Drosophila oocytes.

Summary: Kv1.3 and KCNE4 form functional channels in leukocytes. KCNE4 associates with the C-terminal domain of Kv1.3 providing two independent and additive mechanisms for the intracellular retention of the complex.

Highlighted Article: The spectraplakin ACF7 and microtubule minus-end-stabilizing protein CAMSAP3 cooperate in organizing non-centrosomal microtubule arrays in intestinal epithelial cells.

Summary: Fission yeast Atg20- and Atg24-family proteins promote starvation-induced autophagy of ER and mitochondria, and we propose that their function is to ensure that autophagosomes are of a sufficient size.

Summary: HMGB2 promotes myoblast proliferation and muscle regeneration through IGF2BP2, which regulates the protein production of cyclin A2 and Myf5.