Cover: The glucocorticoid receptor (GR) is gated by REV-ERBα to the nucleus at a particular time of the day. Murine liver was probed at zeitgeber time (ZT)20 (where ZT0 is lights on and ZT12 is lights off ) with antibodies specific forGR (red) and HSP90 (green). Nuclei were visualized using DAPI (blue). Photo: Rohit Chavan. See article by T. Okabe et al. (pp. 4143–4154).
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IN THIS ISSUE
CELL SCIENTISTS TO WATCH
HEAT repeats – versatile arrays of amphiphilic helices working in crowded environments?
Summary: HEAT repeats, repetitive arrays of amphiphilic helices found in many eukaryotic proteins, flexibly change their own conformations and support dynamic protein–protein interactions in crowded environments in the cell.
Bidirectional traffic between the Golgi and the endosomes – machineries and regulation
Summary: Recent advances in understanding the bidirectional trafficking pathway between the Golgi and the endosomes are discussed, including how they have helped to exemplify and put together long-debated models of transport.
Calsequestrin interacts directly with the cardiac ryanodine receptor luminal domain
Summary: Direct physical and functional calsequestrin 2 association with the ryanodine receptor luminal domain is the minimal requirement to form the sarcoplasmic reticulum Ca2+ sensor, which governs cardiac Ca2+ homeostasis and reliable heartbeat.
Transient fusion ensures granule replenishment to enable repeated release after IgE-mediated mast cell degranulation
Highlighted Article: Kiss-and-run and cavicapture are the dominant mechanisms associated with granule replenishment in mast cells after IgE-mediated degranulation.
The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability
Summary: We identify a Hedgehog-pathway-associated ubiquitin ligase adapter as a direct interaction partner of the deubiquitylase USP21 and discover a close interplay between USP21 and protein kinase A in regulating Gli1.
Anaphase asymmetry and dynamic repositioning of the division plane during maize meiosis
Highlighted Article: Meiotic chromosomes are segregated asymmetrically in anaphase, and the phragmoplast dynamically adjusts its location to correct for metaphase spindle misplacement within the cell volume.
RNA-binding protein HuR regulates nuclear import of protein
Summary: We show that the RNA-binding protein HuR plays a key role in controlling expression of multiple components of the nuclear import machinery, presenting a new mechanism by which nuclear import of proteins is regulated.
Acsl, the Drosophila ortholog of intellectual-disability-related ACSL4, inhibits synaptic growth by altered lipids
Highlighted Article: Acsl, the Drosophila ortholog of the long-chain acyl-CoA synthetase 4 (ACSL4), inhibits synaptic growth by upregulating C16:1 fatty acyls and downregulating the abundance of raft-associated lipids.
Rnd3-induced cell rounding requires interaction with Plexin-B2
Summary: The Rho GTPase Rnd3 is known to alter cell shape and the actin cytoskeleton. Here, the semaphorin receptor plexin-B2 is identified as a new Rnd3 partner that mediates its effects on cell shape.
Pex9p is a new yeast peroxisomal import receptor for PTS1-containing proteins
Highlighted Article: Oleate-inducible targeting of malate synthases into yeast peroxisomes is facilitated by the newly identified PTS1 receptor Pex9p, which exhibits a strong selectivity for these isoenzymes.
Characterization of proteome dynamics during growth in oleate reveals a new peroxisome-targeting receptor
Highlighted Article: A high-content screen uncovered many changes in protein localization in yeast grown in oleate and highlighted a new condition-specific peroxisomal protein, Pex9, which targets a subset of proteins to peroxisomes.
Regulation of Hspb7 by MEF2 and AP-1: implications for Hspb7 in muscle atrophy
Summary: Analysis of ChIP-seq data revealed a cohort of dual MEF2 and AP-1 target genes involved in cytoskeletal organization. Regulation of Hspb7 by MEF2 and AP-1 was further characterized in models of muscle atrophy.
VEGF induces signalling and angiogenesis by directing VEGFR2 internalisation through macropinocytosis
Highlighted Article: VEGFR2 internalises constitutively through clathrin-mediated endocytosis, whereas VEGF induces a new internalisation itinerary for VEGFR2 through macropinocytosis, which is essential for its signalling.
Localized translation regulates cell adhesion and transendothelial migration
Summary: Translation affects adhesion and invasion potential of spreading initiation centers (SICs) producing mesenchymal cells, but not epithelial cells, which are deprived of SICs
New links between SOD1 and metabolic dysfunction from a yeast model of amyotrophic lateral sclerosis
Summary: In a new yeast model of ALS we have discovered for the first time that mutations in Sod1 can lead to the formation of toxic, soluble proteins that disrupt metabolic regulation.
PRL-3 disrupts epithelial architecture by altering the post-mitotic midbody position
Summary: The cancer-promoting phosphatase PRL-3 triggers ectopic lumen formation through midbody mispositioning by accelerating cytokinesis, suggesting a new oncogenic mechanism.
REV-ERBα influences the stability and nuclear localization of the glucocorticoid receptor
Summary: Nuclear localization of the glucocorticoid receptor that is dependent on the time of day is altered at the post-translational level by the absence of REV-ERBα, affecting expression GR target genes.
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