Issues

Summary: A broad evolutionary comparison of eukaryotic nucleocytoplasmic bridging complexes suggests that they might have evolved from protein complexes involved in attaching centrosomes to the nuclear envelope.

Summary: Tescalcin is a Ca²⁺-binding protein that regulates cell differentiation through interactions with NHE1, GSK3, the COP9 signalosome and some transcription factors. It is associated with cancer and developmental abnormalities.

Highlighted Article: The satellite-III non-coding RNAs, expressed only during heat shock in human cells, recruit transcription factors to their nuclear foci, contributing to heat-shock-induced transcriptional repression.

Summary: Large-scale chromatin remodeling with dynamic alteration of H3K9 modifications occurred during male meiosis I in rice. This impacted on pivotal meiotic events and was dependent on the germline-specific Argonaute protein MEL1.

Highlighted Article: TRIM17 regulates selective autophagy by inhibiting the degradation of a range of substrates but promoting the autophagic removal of midbodies. Thus TRIM17 facilitates the precise discrimination between potential autophagy substrates.

Summary: Phosphorylation of calponin-3 by MEKK1, which is regulated by actomyosin contraction, leads to an increase in cell-generated traction stress, forming a new positive-feedback loop in the cellular contractile machinery.

Highlighted Article: A previously unrecognized PDZ ligand motif in the RhoGAP protein DLC3 is shown to direct the protein to adherens junctions through interaction with the polarity protein Scribble, where it locally regulates RhoA.

Summary: Erv14 interacts with brome mosaic virus protein 1a, whose perinuclear ER localization requires Erv14 and the COPII coat components Sec24, Sec13 and Sec31, in contrast to their canonical roles in protein ER exit.

Highlighted Article: Both, the microtubule-binding domain of Kid, which is activated by dephosphorylation of Thr463 at anaphase onset, and its coiled-coil domain inhibit the generation of polar ejection force, thereby facilitating chromosome segregation.

Summary: An ARHGEF10 localization analysis using a novel in-house antibody revealed ARHGEF10 localization on vesicles emerging from the Golgi apparatus. A further proposal suggests that ARHGEF10 function is related to Rab8 localization on these vesicles and cell invasiveness.

Summary: Prion protein (PrP)-containing cytosolic aggresomes are components of a quality-control mechanism of the ER. PrP molecules that fail to enter the ER will not be deposited in pre-existing aggresomes.

Summary: Haspin kinase is a regulator of meiotic bipolar spindle assembly, which is mediated by acentriolar microtubule-organizing centers (MTOCs), and acts by regulating the localization of AURKC to the MTOCs in mouse oocytes.

Summary: Talin2, previously presumed to function redundantly with talin1, binds to β integrins more strongly than talin1, and generates traction force to regulate invadopodium formation and cell invasion.

Summary: Deletion of the gene encoding the G-protein subunit Gα12 prevents mouse kidneys from developing the kidney cysts induced by Pkd1 inactivation, which indicates that Gα12 signaling is crucial for renal cystogenesis.