Issues
-
Cover image
Cover Image
Cover: Soft X-ray tomography was used to create 3D tomograms of sickling red blood cells. By analysing their protrusions, the sickling process can be monitored and the efficacy of possible drug treatments can be assessed. Fifty-five untreated sickled red blood cells are shown here to illustrate their varied morphology. See article by M. C. Darrow et al. (pp. 3511–3517).
- PDF Icon PDF LinkTable of contents
- PDF Icon PDF LinkIssue info
IN THIS ISSUE
STICKY WICKET
CELL SCIENCE AT A GLANCE
Cancer metabolism at a glance
Summary: This article indicates metabolic pathways essential for cancer growth and survival, with an emphasis on anticancer therapies that are associated with such metabolic vulnerabilities.
COMMENTARY
Collective migration and cell jamming in asthma, cancer and development
Summary: In development and wound repair, cellular unjamming promotes cooperative cellular migration, whereas in cancer invasion, asthma and aberrant wound repair, it unleashes remarkably asocial cellular misbehavior.
RESEARCH ARTICLES
Efferocytosis and extrusion of leukocytes determine the progression of early mycobacterial pathogenesis
Highlighted Article: Mycobacterial infection in zebrafish larvae was explored using a combination of light and electron microscopy. Macrophage burst events resulted in a progression of infection, whereas epithelium-mediated extrusion of infected immune cells abated infection.
The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin
Summary: We describe a new role for RNF146 and tankyrase in maintaining the Crumbs complex and apical-basal integrity in epithelial cells through regulation of ADP-ribosylation and ubiquitin-dependent degradation of the angiomotin AmotL2.
Persistent nuclear actin filaments inhibit transcription by RNA polymerase II
Highlighted Article: Depletion of actin in the nucleus by polymerization into stable nuclear actin filaments inhibits the actin–polymerase-II interaction, resulting in impaired RNA polymerase II activity, localization, and gene recruitment.
Drosophila Kette coordinates myoblast junction dissolution and the ratio of Scar-to-WASp during myoblast fusion
Summary: The Drosophila protein Kette is essential for myoblast fusion. It controls the dissolution of electron-dense plaques and the ratio of Scar and WASp proteins in fusion-competent myoblasts during fusion pore formation.
Bradykinin promotes neuron-generating division of neural progenitor cells through ERK activation
Highlighted Article: Bradykinin induces neuron-generating division in vitro and in vivo, lengthening the G1 phase of the cell cycle and TIS21 expression. Neurogenesis through kinin-B2 receptor signaling was dependent on sustained ERK activation.
Tensin 3 is a new partner of Dock5 that controls osteoclast podosome organization and activity
Summary: Tensin 3 regulates podosome patterning in osteoclasts and bone resorption. Here, we show that tensin 3 is a partner of the Rac exchange factor Dock5 that stimulates its activity.
Local Ras activation, PTEN pattern, and global actin flow in the chemotactic responses of oversized cells
Highlighted Article: The chemotactic response system of Dictyostelium cells can accommodate larger cells, in a way that involves asymmetric Ras activation in turning protrusions, unconventional PTEN patterns and tail-directed actin flow during the establishment of polarity.
Proplatelet formation is selectively inhibited by collagen type I through Syk-independent GPVI signaling
Summary: Binding of collagen type I to GPVI on megakaryocytes inhibits premature proplatelet formation by a Syk-independent pathway that is distinct from GPVI signaling in platelets.
The membrane trafficking and functionality of the K+-Cl− co-transporter KCC2 is regulated by TGF-β2
Summary: TGF-β2 promotes K+-Cl−-co-transporter KCC2 trafficking and functional activation in hippocampal neurons through a TGF-β2, CREB and Rab11b signaling pathway.
Kinesin-1 sorting in axons controls the differential retraction of arbor terminals
Summary: Axonal transport of kinesin-1 and microtubule dynamics are differentially regulated between terminals in a single axon, and contribute to shaping the axonal arbor by differentially regulating retraction of terminals.
TOOLS AND TECHNIQUES
Visualizing red blood cell sickling and the effects of inhibition of sphingosine kinase 1 using soft X-ray tomography
Highlighted Article: Soft X-ray cryotomography revealed an inverse relationship between sickle RBC volume and number of protrusions upon sickling. Subtomogram analysis showed beneficial effects with Sphk1 inhibitor treatment.
RETRACTION
ARTICLES OF INTEREST IN OUR OTHER JOURNALS
From Development
2024 Journal Meeting 'Diversity and Evolution in Cell Biology'
Registration is open for our 2024 Journal Meeting Diversity and Evolution in Cell Biology, which aims to bring together evolutionary biologists and cell biologists investigating diverse aspects of cellular physiology. Early-bird deadline is 19 January 2024.
FocalPlane image competition winner: Rebecca Simkin
We are delighted to announce that the winner of the 2023 FocalPlane image competition is Rebecca Simkin. Rebecca’s image, ‘Neuromuscular junctions’, depicts four NMJs in a lumbrical muscle, located in the hind paw of a wildtype mouse. Read the full interview here.
Reasons to submit to Journal of Cell Science
There are many benefits to publishing in Journal of Cell Science - read more about why you should choose JCS or visit our submission page now.
Say hello, wave goodbye
Read & Publish: what authors say
We have had wonderful feedback from authors who have published in our journal and benefitted from Read & Publish agreements arranged by their institutional libraries. Read about their experiences.
