Skip to Main Content

Advertisement

Skip Nav Destination

Issues

IN THIS ISSUE

STICKY WICKET

CELL SCIENTISTS TO WATCH

CELL SCIENCE AT A GLANCE

Summary: This Cell Science at a Glance and the accompanying poster highlights the main cellular regulators of transcription factors that are involved in mammalian autophagy and their target genes.

HYPOTHESIS

Summary: Similarities between the regulation of structure and plasticity of occluding junctions and the synapse suggest a common derivation from an ancestral pleated septate junction. Thus, studies on one type of junction may be relevant to understand another.

SHORT REPORTS

Highlighted Article: This paper reports the first structural analysis of the entire caveolar protein coat isolated intact from mammalian cells, and shows that the coat is composed of two morphologically distinct layers.

Summary: Genetic evidence suggests that necrotic pyknosis is distinct from apoptotic pyknosis because of phosphorylation of BAF, which results in a transient detachment of chromatin from the nuclear envelope.

RESEARCH ARTICLES

Highlighted Article: By suppressing Ddit4l expression, thereby enabling MTOR activation in cumulus cells, oocytes promote cumulus cell development and survival, which in turn ensures the production of functionally normal eggs.

Summary: Numb binds the YxNxxF motif in the cytoplasmic C-terminus of EAAT3 and drives its endocytosis in non-polarized cells and its apical sorting in polarized cells.

Highlighted Article: Prickle localizes adjacent to focal adhesions and regulates microtubule targeting to focal adhesions in cooperation with CLASPs and LL5β, thereby promoting focal adhesion disassembly to stimulate cell migration.

Summary: The Src kinases Hck, Fgr and Lyn, and the Abl kinase Arg control Leishmania uptake by macrophages and subsequent infection. Hence, kinase inhibitors could potentially be used to treat leishmaniasis.

Highlighted Article: Characterization of the RNA-binding protein Puf1 as an important regulator required for the maintenance of late-stage gametocytes, the sexual form required for transmission to mosquitoes, in the malaria parasite.

Summary: Ligand–dose thresholds control ligand-dependent responses. To establish the hormonal threshold for driving meiosis, a stimulus-dependent positive regulatory pathway competes against negative feedback from cell cycle machinery.

Highlighted Article: A balanced nucleotide pool is required to promote optimal Chk1 activation and downstream checkpoint efficiency, preventing the accumulation of unreplicated DNA in mitosis and ultrafine anaphase bridge formation.

Summary: CO modulates astrocytic metabolism and initiates communication pathways in a paracrine manner in order to rescue neurons from cell death, which is dependent on P1 adenosine, P2 ATP and TrkB receptors.

Summary: Spatial regulation of MAPKKK proteins remains poorly characterized in fission yeast. Skb5, an SH3 adaptor, was shown to attenuate Pmk1 MAPK signaling by regulating the subcellular distribution of the Mkh1 MAPKKK.

RETRACTION

ARTICLES OF INTEREST IN OUR OTHER JOURNALS

From Development
Close Modal

or Create an Account

Close Modal
Close Modal