Issues

Summary: This brief review and the poster illustrate the different steps and specialised mechanisms used to focus secretion at the CTL immune synapse that allow CTLs to be such efficient and precise serial killers.

Summary: This Commentary presents the effects of hypoxia during embryonic development of somites, and myoblast and satellite cell proliferation and differentiation in vertebrates.

Highlighted Article: The nanoscale organization of proteins in the desmosome, a structure mediating strong cell–cell adhesion, is elucidated by dSTORM super-resolution fluorescence microscopy.

Summary: The baculovirus AcMNPV nucleocapsid contains a WASP-like protein that induces actin polymerization. This baculovirus-induced actin polymerization is involved in the nuclear import of the nucleocapsid.

Highlighted Article: Outside-in integrin activation regulates integrin turnover. Furthermore, integrin activation drives the developmental stabilization of cell–ECM adhesion by decreasing integrin turnover during embryogenesis.

Summary: The downregulation of Arg kinase, induced in human primary tubular cell cultures by incubation in a high glucose concentration, is specifically involved in TGF-β1 overproduction that activates fibroblasts.

Highlighted Article: S. aureus invasion of endothelial cells, which underlies S. aureus sepsis and endocarditis, depends on recycling-endosome-mediated recruitment of Cdc42GAP, a negative regulator of the Rho GTP-binding protein Cdc42.

Summary: CDH11 regulates collagen and elastin synthesis by both affecting the mechanical properties and contractile function of animal tissues through TGF-β and ROCK pathways.

Highlighted Article: We demonstrate that LAR, a receptor tyrosine phosphatase, signals through CDK1 to promote adhesion complex formation and adhesion to the extracellular matrix.

Summary: Analysis of hyperacetylated microtubule structures revealed overlapping and distinct functions of HDAC6 and SIRT2. Specifically, only SIRT2 acts to deacetylate hyperacetylated perinuclear microtubules.

Summary: The progesterone synthetic response of preovulatory granulosa cells might be facilitated by dephosphorylation of MAP2D and phosphorylation of vimentin, resulting in reorganization of vimentin filaments.

Summary: Retinoic acid stabilizes HRas protein during neurogenesis, and this is required for the neural stem cell differentiation into neurons and murine brain development.

Summary: We identify a new K⁺ channel, denoted KCN11, that is localized to the contractile vacuole, and functions in contractile vacuole contraction and osmoregulation in Chlamydomonas reinhardtii.

Summary: Aurora A kinase and PP6 phosphatase are required for spindle positioning in C. elegans embryos and human cells by modulating the localization of cortical force generators.

Summary: Intraflagellar transport machinery is responsible for the construction of cilia and flagella. We show that in trypanosomes it is required for the maintenance of flagellum integrity but not of organelle length.

Summary: Two enzymes in one-carbon metabolism play a pivotal role in controlling assembly and disassembly of a filamentous structure of IMPDH that might act as an adaptive mechanism in nucleotide homeostasis.