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IN THIS ISSUE

STICKY WICKET

CELL SCIENTISTS TO WATCH

OPINION

Summary: This Opinion article examines key concepts underlying our understanding of stem cell quiescence that can be attributed to studies in yeast.

RESEARCH ARTICLES

Highlighted Article: Plectin protects the nucleus of keratinocytes from deformation by forming a dense, cross-linked keratin network that resists both tensile and compressive forces.

Summary: mRNA translational control is vital for gamete development. One of three eIF4Es expressed in C. elegans germ cells recruits mRNAs at critical junctures for both egg and sperm maturation.

Highlighted Article: Ras-activated Dsor1 (MEK in mammals) promotes Wnt signaling in normal Drosophila development. This interaction is conserved in mammalian cells.

Summary: Ras regulator Rabex-5 restricts Notch during Drosophila embryonic and larval hematopoiesis to maintain hematopoietic homeostasis and might serve as an axis to coordinate Ras and Notch signaling.

Highlighted Article: Mitosis is an established target for cancer chemotherapy. We show that the inhibition of protein phosphatase PP1 causes an arrest in mid-mitosis that often culminates in cell death.

Summary: The proper amount of the polarity determinant Crumbs is crucial for apico-basal epithelial cell polarity. Here, we show that its level is controlled by Stardust-dependent stabilization and AP-2-mediated endocytosis.

Highlighted Article: We present here the findings of a screen for ion channels regulating cilia in renal cells. The properties of four ion channels suggest a role for membrane subdomains at the base of the cilium.

Summary: The balance of CDK9 and LARP7 plays a key role in cardiomyocyte proliferation and response to injury. LARP7 represents a potentially novel therapeutic target in promoting recovery from injury.

Highlighted Article: Tethering analysis using various centromere and kinetochore factors, and chromatin modifiers reveals that CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly.

Summary: CD2AP reduces trafficking of GSVs from the perinuclear region to the plasma membrane in podocytes and attenuates glucose uptake, possibly due to a defect in the uncoating of clathrin-coated vesicles.

Summary: Fascin associates directly with microtubules independently of F-actin binding, and this contributes to microtubule dynamics, adhesion assembly and cell migration.

Summary: Purinergic signaling regulates unconventional secretion of transglutaminase-2 (TG2) and explains the link between aberrant protein modifications and inflammatory responses in TG2-dependent autoimmunity.

Summary: These findings show that recycling of cell adhesion molecules through endocytosis promotes their ability to control cell migration.

Summary: The cell adhesion molecule CHL1 interacts with the constitutively active isoform of the serotonin receptor 2c to regulate serotonin-receptor-2c-dependent signaling and exploratory behavior in mice.

Summary: A characterization of the defects at different stages of the iron-sulfur cluster biogenesis that result in nuclear DNA damage and constitutively activate a non-canonical checkpoint pathway in S. cerevisiae.

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